G protein-coupled receptor 109A

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Synonym

HM74a, Nicotinic acid receptor 1, G protein-coupled receptor 109A, GPR109A, PUMAG, HM74A, Puma-g, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, HM74b

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:18.20 spleen:226.90 thymus:25.80 bone marrow:- adipose:80.70 bone:- skin:28.80
GeneChip cerebrum:3.83 cerebellum:3.76 brain stem:3.80 corpus callosum/glia:3.86 pineal gland:- peripheral nerve:4.14 spine:4.18 retina:- eye:- artery/aorta:5.10 vein:4.22 lymphnode:5.51 peripheral blood:- spleen:6.84 thymus:4.77 bone marrow:8.18 adipose:6.89 bone:- skin:7.43
CAGE cerebrum:0.25 cerebellum:- brain stem:0.72 corpus callosum/glia:0.24 pineal gland:0.26 peripheral nerve:- spine:0.58 retina:- eye:- artery/aorta:1.52 vein:1.83 lymphnode:1.63 peripheral blood:- spleen:2.25 thymus:0.61 bone marrow:- adipose:2.64 bone:- skin:-
RNA-seq cerebrum:0.07 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.74 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.34 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:29.10 prostate:45.10 ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:-     liver/hepato:-        lung:73.30    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.16 placenta:5.14 prostate:4.91 ovary:3.82 testis:4.18 heart:4.17 muscle:3.90 esophagus:8.04 stomach:4.13 intestine:4.16 colon:4.03 liver/hepato:4.33 lung:7.51 bladder:- kidney:3.99 pituitary:4 thyroid/parathyroid:4.01 adrenal gland:3.87 pancreas:4.38 breast:6.24 salivary:4.15
CAGE uterus:1.16 placenta:1.96 prostate:2.08 ovary:0.68 testis:1.21 heart:1.00 muscle:0.21 esophagus:2.77 stomach:- intestine:0.38 colon:0.68     liver/hepato:0.78    lung:2.51 bladder:1.27 kidney:0.21 pituitary:0.26 thyroid/parathyroid:0.23 adrenal gland:- pancreas:0 breast:2.11 salivary:1.28
RNA-seq uterus:- placenta:- prostate:2.13 ovary:0.10 testis:0.72 heart:0.17 muscle:0.15 esophagus:- stomach:- intestine:- colon:0.59     liver/hepato:0.05        lung:3.62    bladder:- kidney:0.64 pituitary:- thyroid/parathyroid:0.22 adrenal gland:0.23 pancreas:- breast:4.05 salivary:-

Gene Information

IDs

Refseq ID NM_177551
Gene ID 338442
Unigene ID Hs.524812
Probe set ID 205220_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000182782
GTEx ID ENSG00000182782

Orthologous Gene

Mouse[1]  NM_030701
Rat[1]  NM_181476

Chromosomal Region

12q24.31  [123,185,840  -  123,187,890]

Gene Family (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR017452  GPCR, rhodopsin-like superfamily
IPR002286  P2 purinoceptor

Link to Pubmed  (Pubmed ID)

2834384
12044878
12477932
12522134
12646212
15489334
16018973
16674924
17932499
18639743
18787507
18983141
19136666
19141678
19502010
19633298
19913121
20184326
20380810
20460384
20628086
20655299
21167710
21454438
21655214
21768093
22267479
22962331
23526298
23658787
23770183
24371223

Gene Ontology  (GO ID)

Biological Process

GO:0050995  negative regulation of lipid catabolic process
GO:0001781  neutrophil apoptosis
GO:0070165  positive regulation of adiponectin secretion
GO:0033031  positive regulation of neutrophil apoptosis

Cellular Component

GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0070553  nicotinic acid receptor activity