interleukin-1 receptor-associated kinase 2

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Synonym

interleukin-1 receptor-associated kinase 2, IRAK-2, Interleukin-1 receptor-associated kinase-like 2, IRAK2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:18.20 spleen:18.90 thymus:12.90 bone marrow:59 adipose:- bone:- skin:4.80
GeneChip nodata
CAGE cerebrum:1.99 cerebellum:- brain stem:2.68 corpus callosum/glia:2.96 pineal gland:1.14 peripheral nerve:- spine:2.08 retina:- eye:- artery/aorta:2.36 vein:2.52 lymphnode:2.63 peripheral blood:- spleen:2.24 thymus:1.84 bone marrow:- adipose:2.95 bone:- skin:-
RNA-seq cerebrum:1.52 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.41 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.10 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:- ovary:37.30 testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:50.90     liver/hepato:-        lung:14.70    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:18.60 salivary:-
GeneChip nodata
CAGE uterus:1.66 placenta:1.32 prostate:2.42 ovary:1.44 testis:1.33 heart:1.75 muscle:2.55 esophagus:2.46 stomach:- intestine:2.10 colon:1.80     liver/hepato:2.62    lung:2.50 bladder:2.52 kidney:1.91 pituitary:1.27 thyroid/parathyroid:1.92 adrenal gland:- pancreas:1.42 breast:1.68 salivary:1.95
RNA-seq uterus:- placenta:- prostate:2.57 ovary:0.86 testis:1.04 heart:0.68 muscle:3.79 esophagus:- stomach:- intestine:- colon:1.51     liver/hepato:1.45        lung:4.43    bladder:- kidney:1.26 pituitary:- thyroid/parathyroid:1.85 adrenal gland:2.12 pancreas:- breast:1.27 salivary:-

Gene Information

IDs

Refseq ID NM_001570
Gene ID 3656
Unigene ID Hs.449207
Probe set ID -
Ensembl ID ENSG00000134070
GTEx ID ENSG00000134070

Orthologous Gene

Mouse[2]  NM_001113553, NM_172161
Rat[1]  NM_001025422, NM_172161

Chromosomal Region

3p25.3  [10,206,549  -  10,285,427]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9374458
9625770
9918122
10191251
10383454
11544529
11744690
12138165
12477932
12493773
12659850
12721283
15276183
15489334
15670593
15761153
17342744
17675297
17878161
18996842
19240061
19423540
19453261
19913121
20056178
20200953
20332216
20379614
20406964
20438785
20485341
20628086
20800603
20937840
21048031
21220427
21606490
21903422
21987572
21988832
22011580
22939624
23724040
24084649

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0070498  interleukin-1-mediated signaling pathway
GO:0007254  JNK cascade
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0006468  protein amino acid phosphorylation
GO:0001959  regulation of cytokine-mediated signaling pathway
GO:0070555  response to interleukin-1
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005829  cytosol
GO:0010008  endosome membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity