forkhead box O4

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Synonym

MGC120490, MLLT7, AFX1, Forkhead box protein O4, Fork head domain transcription factor AFX1, FOXO4, AFX

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:17.60 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:36.40 spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:- skin:9.60
GeneChip cerebrum:6.69 cerebellum:6.46 brain stem:6.67 corpus callosum/glia:6.89 pineal gland:- peripheral nerve:5.86 spine:6.22 retina:- eye:- artery/aorta:5.98 vein:6.59 lymphnode:6.16 peripheral blood:- spleen:6.03 thymus:5.66 bone marrow:6.62 adipose:6.30 bone:- skin:5.92
CAGE cerebrum:2.70 cerebellum:- brain stem:2.72 corpus callosum/glia:2.89 pineal gland:2.34 peripheral nerve:- spine:2.75 retina:- eye:- artery/aorta:2.38 vein:2.20 lymphnode:1.69 peripheral blood:- spleen:1.86 thymus:2.04 bone marrow:- adipose:2.35 bone:- skin:-
RNA-seq cerebrum:3.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.23 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.94 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:94.70 prostate:- ovary:- testis:4.30 heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:10.60        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:- salivary:-
GeneChip uterus:6.01 placenta:7.84 prostate:5.67 ovary:6.60 testis:5.99 heart:6.57 muscle:6.74 esophagus:6.25 stomach:6.26 intestine:6.21 colon:6.64 liver/hepato:6.31 lung:6.26 bladder:- kidney:6.41 pituitary:6.03 thyroid/parathyroid:5.93 adrenal gland:6.84 pancreas:6.56 breast:6.13 salivary:6.35
CAGE uterus:2.37 placenta:5.37 prostate:2.46 ovary:2.52 testis:3.20 heart:2.71 muscle:2.62 esophagus:2.66 stomach:- intestine:2.34 colon:2.51     liver/hepato:1.51    lung:2.22 bladder:2.44 kidney:2.09 pituitary:1.80 thyroid/parathyroid:2.39 adrenal gland:- pancreas:2.08 breast:2.19 salivary:2.78
RNA-seq uterus:- placenta:- prostate:4.03 ovary:4.05 testis:3.19 heart:3.11 muscle:4.51 esophagus:- stomach:- intestine:- colon:3.40     liver/hepato:1.82        lung:3.40    bladder:- kidney:2.08 pituitary:- thyroid/parathyroid:3.47 adrenal gland:2.63 pancreas:- breast:3.86 salivary:-

Gene Information

IDs

Refseq ID NM_005938
Gene ID 4303
Unigene ID Hs.584654
Probe set ID 205451_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000184481
GTEx ID ENSG00000184481

Orthologous Gene

Mouse[1]  NM_018789
Rat[1]  NM_001106943

Chromosomal Region

Xq13.1  [70,316,047  -  70,323,385]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

7529552
9010221
9341872
10217147
10518537
10783894
10880363
10921784
10973497
11313479
11352721
11435445
11689711
11777915
11779849
11884591
12192052
12477932
12761217
12960271
12964026
14690436
15084259
15126506
15342556
15489334
15538382
15688004
15688030
15824087
15905404
16054032
16114898
16215946
16272144
16571842
16964248
17244620
18648506
18665269
18692812
18794148
19244250
19416966
19560465
19932102
20037138
20136501
20348951
20570964
20733005
20874444
20934750
21123876
21388494
21454807
21510935
21525355
21536589
21567078
21613825
21708191
21934092
22112832
22125836
22285440
22411791
23333309
23551888
23707940
23770673
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0007050  cell cycle arrest
GO:0009790  embryonic development
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0000080  G1 phase of mitotic cell cycle
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0007095  mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0007517  muscle organ development
GO:0016525  negative regulation of angiogenesis
GO:0008285  negative regulation of cell proliferation
GO:0051151  negative regulation of smooth muscle cell differentiation
GO:0048011  nerve growth factor receptor signaling pathway
GO:0048513  organ development
GO:0007389  pattern specification process
GO:0048015  phosphoinositide-mediated signaling
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0051090  regulation of transcription factor activity
GO:0006355  regulation of transcription, DNA-dependent
GO:0048863  stem cell differentiation
GO:0009888  tissue development
GO:0006366  transcription from RNA polymerase II promoter

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0003690  double-stranded DNA binding
GO:0019899  enzyme binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding