MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Synonym

MRE11 homolog 1, ATLD, Double-strand break repair protein MRE11A, MRE11B, MRE11, MRE11A, HNGS1, MRE11 meiotic recombination 11 homolog A

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:19

cerebellum:12.60

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:-

spine:112.30

retina:-

eye:23.50

artery/aorta:-

vein:-

lymphnode:70.80

peripheral blood:36.40

spleen:37.80

thymus:25.80

bone marrow:39.40

adipose:-

bone:25.60

skin:38.40

GeneChip

cerebrum:4.40

cerebellum:4.01

brain stem:4.29

corpus callosum/glia:4.74

pineal gland:-

peripheral nerve:4.63

spine:4.73

retina:-

eye:-

artery/aorta:4.76

vein:4.90

lymphnode:5.56

peripheral blood:-

spleen:5.52

thymus:6.44

bone marrow:5.83

adipose:4.98

bone:-

skin:4.82

CAGE

cerebrum:2.84

cerebellum:-

brain stem:2.95

corpus callosum/glia:2.91

pineal gland:2.81

peripheral nerve:-

spine:3.09

retina:-

eye:-

artery/aorta:2.58

vein:3.00

lymphnode:3.12

peripheral blood:-

spleen:3.29

thymus:3.49

bone marrow:-

adipose:3.07

bone:-

skin:-

RNA-seq

cerebrum:0.07

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.75

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.70

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:27.30

placenta:40.10

prostate:-

ovary:37.30

testis:8.70

heart:-

muscle:40.20

esophagus:-

stomach:-

intestine:32.40

colon:8.50

liver/hepato:63.30

lung:29.30

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:-

breast:18.60

salivary:-

GeneChip

uterus:5.23

placenta:5.74

prostate:5.42

ovary:5.10

testis:5.09

heart:4.76

muscle:4.38

esophagus:4.91

stomach:4.96

intestine:4.72

colon:4.78

liver/hepato:4.66

lung:5.10

bladder:-

kidney:4.45

pituitary:4.26

thyroid/parathyroid:4.76

adrenal gland:4.95

pancreas:4.77

breast:5.03

salivary:4.75

CAGE

uterus:3.38

placenta:2.94

prostate:3.10

ovary:2.91

testis:2.79

heart:2.66

muscle:2.39

esophagus:2.86

stomach:-

intestine:2.64

colon:2.74

liver/hepato:2.50

lung:2.84

bladder:3.16

kidney:2.65

pituitary:2.92

thyroid/parathyroid:2.94

adrenal gland:-

pancreas:2.41

breast:3.09

salivary:2.46

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.19

testis:0.45

heart:0.53

muscle:1.06

esophagus:-

stomach:-

intestine:-

colon:0.74

liver/hepato:0.19

lung:1.11

bladder:-

kidney:0.13

pituitary:-

thyroid/parathyroid:0.39

adrenal gland:0.70

pancreas:-

breast:0.07

salivary:-

IDs

Refseq ID	NM_005590
Gene ID	4361
Unigene ID	Hs.192649
Probe set ID	205395_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000020922
GTEx ID	ENSG00000020922

Orthologous Gene

Mouse[1]	NM_018736
Rat[1]	NM_022279

Chromosomal Region

11q21 [94,152,895 - 94,227,074]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

LRG_85 [5,001 - 81,575]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0000075	cell cycle checkpoint
GO:0008283	cell proliferation
GO:0032508	DNA duplex unwinding
GO:0006310	DNA recombination
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0000724	double-strand break repair via homologous recombination
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0045087	innate immune response
GO:0032876	negative regulation of DNA endoreduplication
GO:0033674	positive regulation of kinase activity
GO:0031954	positive regulation of protein amino acid autophosphorylation
GO:0032481	positive regulation of type I interferon production
GO:0007131	reciprocal meiotic recombination
GO:0000019	regulation of mitotic recombination
GO:0006974	response to DNA damage stimulus
GO:0007062	sister chromatid cohesion
GO:0007129	synapsis
GO:0007004	telomere maintenance via telomerase

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005829	cytosol
GO:0030870	Mre11 complex
GO:0005730	nucleolus
GO:0005654	nucleoplasm
GO:0005634	nucleus

Molecular Function

GO:0008408	3'-5' exonuclease activity
GO:0004003	ATP-dependent DNA helicase activity
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0004520	endodeoxyribonuclease activity
GO:0030145	manganese ion binding
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function