NLR family, pyrin domain containing 2

 jump to detail

Synonym

PYPAF2, PAN1, NALP2, NACHT, leucine rich repeat and PYD containing 2, FLJ20510, PYRIN-containing APAF1-like protein 2, Nucleotide-binding site protein 1, PYRIN domain and NACHT domain-containing protein 1, NBS1, NACHT, LRR and PYD-containing protein 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.14 cerebellum:3.81 brain stem:4.08 corpus callosum/glia:3.66 pineal gland:- peripheral nerve:4.25 spine:3.95 retina:- eye:- artery/aorta:3.95 vein:3.80 lymphnode:4.76 peripheral blood:- spleen:4.82 thymus:4.48 bone marrow:4.16 adipose:4.01 bone:- skin:4.23
CAGE cerebrum:0.33 cerebellum:- brain stem:0.30 corpus callosum/glia:0.13 pineal gland:0.36 peripheral nerve:- spine:0.13 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0.52 peripheral blood:- spleen:0.32 thymus:0.68 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.23 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:4.22 placenta:6.25 prostate:4.68 ovary:3.77 testis:6.11 heart:3.63 muscle:3.88 esophagus:5.68 stomach:4.44 intestine:4.15 colon:4.75 liver/hepato:3.75 lung:4.31 bladder:- kidney:4.23 pituitary:4.65 thyroid/parathyroid:4.62 adrenal gland:3.89 pancreas:3.68 breast:5.12 salivary:4.32
CAGE uterus:0.48 placenta:1.17 prostate:0.08 ovary:0.20 testis:1.41 heart:0.04 muscle:0 esophagus:1.04 stomach:- intestine:0.57 colon:0.27     liver/hepato:0    lung:0.25 bladder:0 kidney:0.82 pituitary:0.62 thyroid/parathyroid:0.41 adrenal gland:- pancreas:0.94 breast:0 salivary:0.83
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.07 testis:0.82 heart:0.00 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.58 pituitary:- thyroid/parathyroid:0.34 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_017852
Gene ID 55655
Unigene ID -
Probe set ID 221690_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000022556
GTEx ID ENSG00000022556

Orthologous Gene

Mouse[1]  NM_177690
Rat[1]  NM_177690

Chromosomal Region

19q13.42  [55,476,438  -  55,512,510]

Gene Family (Interpro ID)

IPR011029  DEATH-like
IPR004020  Pyrin

Link to Pubmed  (Pubmed ID)

8125298
11250163
11270363
12019269
12387869
12477932
12563287
14702039
15030775
15456791
15489334
15817483
16344560
17046979
17178784
17420470
17435760
18056399
18285453
18369178
18772453
19074885
19103770
19300480
19534089
19900269
20403135
20800603
21832049
21906983
21976665
22909446
23128233
23360675
23625868
23644288

Gene Ontology  (GO ID)

Biological Process

GO:0043280  positive regulation of caspase activity
GO:0050718  positive regulation of interleukin-1 beta secretion

Cellular Component

GO:0005737  cytoplasm

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0032090  Pyrin domain binding