mitogen-activated protein kinase 11

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Synonym

p38-2, SAPK2B, Stress-activated protein kinase 2, Mitogen-activated protein kinase p38 beta, SAPK2, MAP kinase p38 beta, PRKM11, P38BETA2, mitogen-activated protein kinase 11, P38B, p38b, MAPK11, p38Beta, Mitogen-activated protein kinase 11

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:- spine:- retina:- eye:23.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.55 cerebellum:6.75 brain stem:6.33 corpus callosum/glia:6.47 pineal gland:- peripheral nerve:6.43 spine:6.29 retina:- eye:- artery/aorta:6.52 vein:6.63 lymphnode:6.42 peripheral blood:- spleen:6.34 thymus:6.41 bone marrow:6.22 adipose:6.31 bone:- skin:6.40
CAGE cerebrum:2.09 cerebellum:- brain stem:1.37 corpus callosum/glia:0.96 pineal gland:1.39 peripheral nerve:- spine:1.21 retina:- eye:- artery/aorta:1.33 vein:1.80 lymphnode:1.21 peripheral blood:- spleen:1.29 thymus:0.33 bone marrow:- adipose:1.76 bone:- skin:-
RNA-seq cerebrum:2.28 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.65 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.88 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:- salivary:-
GeneChip uterus:6.41 placenta:6.24 prostate:6.07 ovary:6.36 testis:5.98 heart:6.35 muscle:6.50 esophagus:6.44 stomach:6.25 intestine:6.40 colon:6.33 liver/hepato:6.43 lung:6.47 bladder:- kidney:6.32 pituitary:6.57 thyroid/parathyroid:6.10 adrenal gland:6.37 pancreas:6.91 breast:6.37 salivary:6.32
CAGE uterus:1.42 placenta:1.02 prostate:0.78 ovary:1.08 testis:0.82 heart:1.27 muscle:0.74 esophagus:1.14 stomach:- intestine:0.66 colon:0.85     liver/hepato:0.14    lung:1.48 bladder:0.64 kidney:1.38 pituitary:1.53 thyroid/parathyroid:0.53 adrenal gland:- pancreas:0.94 breast:1.80 salivary:0.83
RNA-seq uterus:- placenta:- prostate:1.42 ovary:2.13 testis:1.42 heart:1.19 muscle:0.49 esophagus:- stomach:- intestine:- colon:1.21     liver/hepato:0.40        lung:2.23    bladder:- kidney:1.97 pituitary:- thyroid/parathyroid:1.37 adrenal gland:3.12 pancreas:- breast:2.55 salivary:-

Gene Information

IDs

Refseq ID NM_002751
Gene ID 5600
Unigene ID Hs.577323
Probe set ID 211500_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000185386
GTEx ID ENSG00000185386

Orthologous Gene

Mouse[2]  NM_011161
Rat[1]  NM_001109532

Chromosomal Region

22q13.33  [50,702,142  -  50,709,196]

Gene Family (Interpro ID)

IPR008351  JNK MAP kinase
IPR008352  MAP kinase, p38
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8663524
9029150
9199504
9207191
9218798
9235954
9430721
9628874
9632706
9687510
9832563
10201954
10207622
10330143
10362531
10391889
10591208
10608813
10744763
10782990
10811012
10820433
10878576
10952989
11154262
11162833
11211234
11359773
11448946
11495898
11551945
11579095
11847341
12171600
12239168
12384504
12454855
12475989
12477932
12510156
12586546
12761180
14522966
14557269
14651992
14680475
14688370
14724572
15048855
15249224
15273249
15304097
15304344
15326477
15356147
15461802
15489334
15708845
15728454
15923648
16120828
16341674
16643845
16966330
17241234
17254968
17380123
17906618
18192325
18950637
19082897
19622861
19706373
19913121
20053787
20056178
20110267
20162623
20188673
20378550
20626350
20628086
20724307
21757713
21832049
21900206
21911485
21988832
22157753
22515544
22522454
23435415
23602568
23625915
23824909

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0010467  gene expression
GO:0045087  innate immune response
GO:0016071  mRNA metabolic process
GO:0042692  muscle cell differentiation
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0051149  positive regulation of muscle cell differentiation
GO:0007243  protein kinase cascade
GO:0007265  Ras protein signal transduction
GO:0051090  regulation of transcription factor activity
GO:0006950  response to stress
GO:0016070  RNA metabolic process
GO:0007165  signal transduction
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005829  cytosol
GO:0005654  nucleoplasm

Molecular Function

GO:0005524  ATP binding
GO:0004707  MAP kinase activity
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity