transforming growth factor, alpha

Synonym

TGFa, TGF-alpha, TGF alpha, ETGF, TGF type 1, EGF-like TGF, TGFA, Transforming growth factor alpha precursor, TGF-a, TFGA, transforming growth factor, alpha

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:46.20

cerebellum:25.20

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:112.30

retina:-

eye:23.50

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:18.90

thymus:-

bone marrow:19.70

adipose:-

bone:-

skin:43.20

GeneChip

cerebrum:6.28

cerebellum:5.46

brain stem:6.72

corpus callosum/glia:7.46

pineal gland:-

peripheral nerve:5.41

spine:7.42

retina:-

eye:-

artery/aorta:4.73

vein:4.69

lymphnode:5.67

peripheral blood:-

spleen:5.17

thymus:4.49

bone marrow:5.42

adipose:4.98

bone:-

skin:6.39

CAGE

cerebrum:2.16

cerebellum:-

brain stem:2.61

corpus callosum/glia:3.32

pineal gland:1.25

peripheral nerve:-

spine:2.47

retina:-

eye:-

artery/aorta:1.10

vein:1.34

lymphnode:2.28

peripheral blood:-

spleen:1.97

thymus:0.46

bone marrow:-

adipose:0.71

bone:-

skin:-

RNA-seq

cerebrum:1.57

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.05

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.01

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:109.40

placenta:-

prostate:-

ovary:-

testis:13

heart:-

muscle:-

esophagus:-

stomach:21.20

intestine:-

colon:76.30

liver/hepato:-

lung:48.90

bladder:125.60

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:53.30

breast:37.20

salivary:-

GeneChip

uterus:4.86

placenta:5.08

prostate:5.40

ovary:4.97

testis:4.37

heart:4.70

muscle:4.51

esophagus:7.40

stomach:5.13

intestine:5.32

colon:5.64

liver/hepato:5.11

lung:5.08

bladder:-

kidney:6.88

pituitary:4.71

thyroid/parathyroid:5.49

adrenal gland:4.50

pancreas:5.02

breast:5.63

salivary:5.15

CAGE

uterus:1.13

placenta:0.68

prostate:1.14

ovary:0.60

testis:0.36

heart:0.19

muscle:0

esophagus:2.27

stomach:-

intestine:2.86

colon:2.56

liver/hepato:1.12

lung:1.63

bladder:1.06

kidney:2.61

pituitary:0.38

thyroid/parathyroid:1.70

adrenal gland:-

pancreas:2.60

breast:0.90

salivary:1.49

RNA-seq

uterus:-

placenta:-

prostate:0.03

ovary:0.42

testis:0.02

heart:0.02

muscle:0.01

esophagus:-

stomach:-

intestine:-

colon:0.01

liver/hepato:0.05

lung:0.10

bladder:-

kidney:1.62

pituitary:-

thyroid/parathyroid:0.11

adrenal gland:1.01

pancreas:-

breast:0.04

salivary:-

IDs

Refseq ID	NM_003236
Gene ID	7039
Unigene ID	Hs.170009
Probe set ID	205016_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000163235
GTEx ID	ENSG00000163235

Orthologous Gene

Mouse[3]	NM_031199
Rat [0]

Chromosomal Region

2p13.3 [70,674,412 - 70,781,325]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000742

EGF-like, type 3

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0008283	cell proliferation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0060749	mammary gland alveolus development
GO:0000165	MAPKKK cascade
GO:0043066	negative regulation of apoptosis
GO:0051781	positive regulation of cell division
GO:0045741	positive regulation of epidermal growth factor receptor activity
GO:0050679	positive regulation of epithelial cell proliferation
GO:0045840	positive regulation of mitosis
GO:0042493	response to drug
GO:0042060	wound healing

Cellular Component

GO:0016323	basolateral plasma membrane
GO:0009986	cell surface
GO:0031410	cytoplasmic vesicle
GO:0005615	extracellular space
GO:0016021	integral to membrane
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane

Molecular Function

GO:0005154	epidermal growth factor receptor binding
GO:0001948	glycoprotein binding
GO:0008083	growth factor activity
GO:0004708	MAP kinase kinase activity
GO:0005515	protein binding

transforming growth factor, alpha

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function