vascular endothelial growth factor B

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Synonym

Vascular endothelial growth factor B precursor, VRF, VEGF-B, vascular endothelial growth factor B, VEGFB, VEGFL, VEGF-related factor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:14.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:105.80 artery/aorta:30 vein:- lymphnode:40.40 peripheral blood:18.20 spleen:18.90 thymus:12.90 bone marrow:39.40 adipose:- bone:25.60 skin:57.60
GeneChip cerebrum:5.99 cerebellum:5.75 brain stem:6.02 corpus callosum/glia:6.11 pineal gland:- peripheral nerve:5.81 spine:6.28 retina:- eye:- artery/aorta:6.79 vein:6.45 lymphnode:6.39 peripheral blood:- spleen:6.01 thymus:5.72 bone marrow:5.33 adipose:7.35 bone:- skin:6.25
CAGE cerebrum:3.57 cerebellum:- brain stem:3.58 corpus callosum/glia:3.84 pineal gland:3.37 peripheral nerve:- spine:3.76 retina:- eye:- artery/aorta:4.43 vein:4.27 lymphnode:3.80 peripheral blood:- spleen:3.63 thymus:3.24 bone marrow:- adipose:4.83 bone:- skin:-
RNA-seq cerebrum:3.39 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.12 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.58 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:43.70 prostate:22.50 ovary:- testis:8.70 heart:25.50 muscle:60.30 esophagus:- stomach:- intestine:- colon:33.90     liver/hepato:10.60        lung:39.10    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:26.70 breast:27.90 salivary:-
GeneChip uterus:6.04 placenta:5.82 prostate:5.94 ovary:6.11 testis:5.26 heart:6.90 muscle:6.40 esophagus:6.05 stomach:6.03 intestine:6.20 colon:6.16 liver/hepato:5.55 lung:6.30 bladder:- kidney:6.44 pituitary:6.79 thyroid/parathyroid:6.78 adrenal gland:6.26 pancreas:6.47 breast:6.47 salivary:6.41
CAGE uterus:3.80 placenta:3.57 prostate:4.38 ovary:4.18 testis:3.40 heart:4.76 muscle:3.39 esophagus:4.02 stomach:- intestine:3.58 colon:3.98     liver/hepato:2.99    lung:4.25 bladder:4.35 kidney:3.69 pituitary:3.62 thyroid/parathyroid:4.09 adrenal gland:- pancreas:4.16 breast:5.39 salivary:3.81
RNA-seq uterus:- placenta:- prostate:5.39 ovary:4.75 testis:4.52 heart:3.80 muscle:3.48 esophagus:- stomach:- intestine:- colon:4.74     liver/hepato:2.72        lung:4.88    bladder:- kidney:3.73 pituitary:- thyroid/parathyroid:4.54 adrenal gland:4.44 pancreas:- breast:5.61 salivary:-

Gene Information

IDs

Refseq ID NM_003377
Gene ID 7423
Unigene ID Hs.78781
Probe set ID 203683_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000173511
GTEx ID ENSG00000173511

Orthologous Gene

Mouse[1]  NM_001185164, NM_011697
Rat [0]  

Chromosomal Region

11q13.1  [64,002,010  -  64,006,259]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8637916
8702615
8889548
8919691
9365524
9684805
9751730
10409677
11122379
12366396
12477932
12652295
12881472
15009103
15489334
16109918
16570043
16616187
16839256
17082651
18259607
18317782
18511699
18537151
18564921
18757827
18930733
19275959
19424629
19483306
19910455
19913121
19948975
20223440
20228789
20308035
20452482
20501651
20628086
20673868
21636803
22172722
22872519
23301033
23350126
23417498
23444216
23553333
23697367
23728940
24561123

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007596  blood coagulation
GO:0060048  cardiac muscle contraction
GO:0060976  coronary vasculature development
GO:0050930  induction of positive chemotaxis
GO:0043066  negative regulation of apoptosis
GO:0010629  negative regulation of gene expression
GO:0043524  negative regulation of neuron apoptosis
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0050918  positive chemotaxis
GO:0051781  positive regulation of cell division
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0060754  positive regulation of mast cell chemotaxis
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0030949  positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0043117  positive regulation of vascular permeability
GO:0006493  protein amino acid O-linked glycosylation
GO:0042493  response to drug
GO:0048010  vascular endothelial growth factor receptor signaling pathway

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016020  membrane
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0042056  chemoattractant activity
GO:0008083  growth factor activity
GO:0008201  heparin binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0043183  vascular endothelial growth factor receptor 1 binding