TNF receptor-associated factor 7

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Synonym

ring finger and WD repeat domain 1, TRAF7, MGC7807, E3 ubiquitin protein ligase TRAF7, TNF receptor-associated factor 7, RNF119, RING finger and WD repeat domain protein 1, RFWD1, RING finger protein 119, DKFZp586I021

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip nodata
CAGE cerebrum:3.59 cerebellum:- brain stem:3.00 corpus callosum/glia:3.06 pineal gland:3.93 peripheral nerve:- spine:3.70 retina:- eye:- artery/aorta:3.99 vein:3.74 lymphnode:4.14 peripheral blood:- spleen:3.82 thymus:3.85 bone marrow:- adipose:3.52 bone:- skin:-
RNA-seq cerebrum:2.48 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.72 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.69 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip nodata
CAGE uterus:3.64 placenta:3.41 prostate:3.59 ovary:3.73 testis:3.59 heart:3.72 muscle:3.92 esophagus:4.22 stomach:- intestine:4.37 colon:4.46     liver/hepato:4.43    lung:3.91 bladder:3.86 kidney:3.79 pituitary:3.44 thyroid/parathyroid:3.72 adrenal gland:- pancreas:4.36 breast:4.47 salivary:3.99
RNA-seq uterus:- placenta:- prostate:3.63 ovary:3.84 testis:3.76 heart:2.12 muscle:3.61 esophagus:- stomach:- intestine:- colon:3.65     liver/hepato:3.29        lung:3.33    bladder:- kidney:3.40 pituitary:- thyroid/parathyroid:3.41 adrenal gland:3.76 pancreas:- breast:3.28 salivary:-

Gene Information

IDs

Refseq ID NM_032271
Gene ID 84231
Unigene ID -
Probe set ID -
Ensembl ID ENSG00000131653
GTEx ID ENSG00000131653

Orthologous Gene

Mouse[1]  NM_001172113, NM_001172114, NM_153792
Rat[1]  NM_001127548, NM_001172114, NM_153792

Chromosomal Region

16p13.3  [2,205,766  -  2,228,130]

Gene Family (Interpro ID)

IPR020472  G-protein beta WD-40 repeat, region
IPR001680  WD40 repeat
IPR019782  WD40 repeat 2
IPR019781  WD40 repeat, subgroup
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

11230166
12477932
14702039
14743216
15001576
15489334
16230348
18029348
19549727
20201926
21139048
21518757
21890473
21903422
21906983
21963094
22105767
22219201
23000965
23128672
23348505
23404370

Gene Ontology  (GO ID)

Biological Process

GO:0000185  activation of MAPKKK activity
GO:0006915  apoptosis
GO:0043410  positive regulation of MAPKKK cascade
GO:0016567  protein ubiquitination
GO:0006355  regulation of transcription, DNA-dependent
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0043231  intracellular membrane-bounded organelle
GO:0005886  plasma membrane
GO:0000151  ubiquitin ligase complex

Molecular Function

GO:0005515  protein binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding