adrenergic receptor, alpha 1a

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Synonym

Alpha-1C adrenergic receptor, Alpha 1A-adrenoceptor, Adra1a, Alpha 1A-adrenoreceptor, Alpha-1A adrenergic receptor, adrenergic receptor, alpha 1a, MGC130524, [a]1a, Adra1c

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.70 cerebellum:18.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:236.40 retina:32.10 eye:- artery/aorta:253.20 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.64 cerebellum:4.75 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.51 spine:4.76 retina:4.45 eye:4.76 artery/aorta:- vein:4.32 lymphnode:4.46 peripheral blood:- spleen:4.19 thymus:- bone marrow:4.43 adipose:5.33 bone:4.31 skin:4.38
CAGE cerebrum:2.47 cerebellum:- brain stem:2.46 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.10 retina:- eye:- artery/aorta:4.25 vein:- lymphnode:0.23 peripheral blood:- spleen:0.16 thymus:1.50 bone marrow:- adipose:- bone:0 skin:1.57
RNA-seq cerebrum:1.13 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:9.10        lung:-    bladder:- kidney:16.10 pituitary:25.80 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.43 placenta:4.71 prostate:4.47 ovary:4.20 testis:4.28 heart:5.19 muscle:4.90 esophagus:- stomach:4.73 intestine:4.39 colon:- liver/hepato:4.91 lung:4.88 bladder:4.52 kidney:5.49 pituitary:4.65 thyroid/parathyroid:- adrenal gland:4.52 pancreas:5.11 breast:4.53 salivary:4.79
CAGE uterus:1.65 placenta:0.29 prostate:1.77 ovary:1.14 testis:0 heart:- muscle:- esophagus:- stomach:0 intestine:0 colon:0.23     liver/hepato:2.02    lung:2.78 bladder:0.93 kidney:- pituitary:0.29 thyroid/parathyroid:- adrenal gland:0.85 pancreas:0 breast:1.72 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.58        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_013461
Gene ID 11549
Unigene ID Mm.57064
Probe set ID 1421659_at  [Mouse430_2]
Ensembl ID ENSMUSG00000045875

Orthologous Gene

Human[7]  NM_000680, NM_033302, NM_033303, NM_033304
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR002233  Adrenergic receptor
IPR001004  Adrenergic receptor, alpha 1C subtype
IPR017452  GPCR, rhodopsin-like superfamily

Link to Pubmed  (Pubmed ID)

7595531
9139936
9590558
9630362
10349636
11042159
11076861
11217851
11306707
11509451
12093905
12466851
12477932
12595294
12782680
14519431
14659805
15231500
16141072
16141073
16171811
16516910
16585965
16602821
17099296
17283256
17384126
17584443
17603545
17636168
18046308
18165681
18332105
18435418
18552157
18552869
18802028
19001095
19259685
19487244
19540213
19632210
19855129
19862476
20136833
21209093
21267068
21335239
21546608
21613371
21722710
21768522
21791575
22120526
22326222
22371491
22569571
22640814
24154525
24297884

Gene Ontology  (GO ID)

Biological Process

GO:0007202  activation of phospholipase C activity
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0007512  adult heart development
GO:0007568  aging
GO:0060402  calcium ion transport into cytosol
GO:0016049  cell growth
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0060073  micturition
GO:0001985  negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0035024  negative regulation of Rho protein signal transduction
GO:0032229  negative regulation of synaptic transmission, GABAergic
GO:0001994  norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0035265  organ growth
GO:0045760  positive regulation of action potential
GO:0060452  positive regulation of cardiac muscle contraction
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0010460  positive regulation of heart rate
GO:0001996  positive regulation of heart rate by epinephrine-norepinephrine
GO:0043410  positive regulation of MAPKKK cascade
GO:0090037  positive regulation of protein kinase C signaling cascade
GO:0045987  positive regulation of smooth muscle contraction
GO:0003084  positive regulation of systemic arterial blood pressure
GO:0001997  positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0045907  positive regulation of vasoconstriction
GO:0055117  regulation of cardiac muscle contraction
GO:0006937  regulation of muscle contraction
GO:0019229  regulation of vasoconstriction
GO:0042493  response to drug
GO:0009725  response to hormone stimulus
GO:0006950  response to stress
GO:0007165  signal transduction

Cellular Component

GO:0016021  integral to membrane
GO:0016020  membrane
GO:0031965  nuclear membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0030315  T-tubule
GO:0030018  Z disc

Molecular Function

GO:0004935  adrenoceptor activity
GO:0004937  alpha1-adrenergic receptor activity
GO:0004930  G-protein coupled receptor activity
GO:0046982  protein heterodimerization activity
GO:0004871  signal transducer activity