apoptotic peptidase activating factor 1

Synonym

apoptotic peptidase activating factor 1, fog, Apaf-1, 6230400I06Rik, KIAA0413, Apoptotic protease-activating factor 1, Apaf1, Apaf1l, mKIAA0413

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:79.90

cerebellum:18.40

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:68.40

artery/aorta:-

vein:-

lymphnode:43.20

peripheral blood:100.60

spleen:52.70

thymus:138.30

bone marrow:-

adipose:-

bone:12.50

skin:31.70

GeneChip

cerebrum:5.19

cerebellum:4.79

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:4.81

spine:4.81

retina:4.29

eye:4.59

artery/aorta:-

vein:7.03

lymphnode:6.21

peripheral blood:-

spleen:6.18

thymus:-

bone marrow:7.52

adipose:5.02

bone:7.54

skin:4.90

CAGE

cerebrum:1.79

cerebellum:-

brain stem:1.55

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:1.96

retina:-

eye:-

artery/aorta:2.25

vein:-

lymphnode:3.15

peripheral blood:-

spleen:3.39

thymus:3.35

bone marrow:-

adipose:-

bone:3.66

skin:2.82

RNA-seq

cerebrum:1.17

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:27.60

prostate:-

ovary:11.50

testis:44.30

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:18.10

lung:40.20

bladder:132.40

kidney:-

pituitary:12.90

thyroid/parathyroid:112.50

adrenal gland:-

pancreas:46.90

breast:13.10

salivary:-

GeneChip

uterus:5.90

placenta:6.18

prostate:4.73

ovary:5.41

testis:4.20

heart:5.06

muscle:5.07

esophagus:-

stomach:5.37

intestine:7.09

colon:-

liver/hepato:4.42

lung:5.70

bladder:5.08

kidney:4.66

pituitary:5.59

thyroid/parathyroid:-

adrenal gland:4.80

pancreas:5.10

breast:5.18

salivary:4.82

CAGE

uterus:2.99

placenta:3.24

prostate:2.33

ovary:2.96

testis:0.99

heart:-

muscle:-

esophagus:-

stomach:1.35

intestine:3.99

colon:4.13

liver/hepato:1.52

lung:3.05

bladder:2.29

kidney:-

pituitary:2.63

thyroid/parathyroid:-

adrenal gland:2.47

pancreas:2.45

breast:2.05

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.32

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:1.68

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_001042558
Gene ID	11783
Unigene ID	Mm.220289
Probe set ID	1450223_at [Mouse430_2]
Ensembl ID	ENSMUSG00000019979

Orthologous Gene

Human[11]	NM_001160, NM_013229, NM_181861, NM_181868, NM_181869
Rat[11]	NM_001160, NM_013229, NM_181861, NM_181868, NM_181869

Chromosomal Region

Gene Family (Interpro ID)

IPR001315	Caspase Recruitment
IPR011029	DEATH-like
IPR020472	G-protein beta WD-40 repeat, region
IPR001680	WD40 repeat
IPR019782	WD40 repeat 2
IPR019781	WD40 repeat, subgroup
IPR011046	WD40 repeat-like-containing domain
IPR017986	WD40-repeat-containing domain
IPR015943	WD40/YVTN repeat-like-containing domain

Gene Ontology (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0008635	activation of caspase activity by cytochrome c
GO:0006915	apoptosis
GO:0007420	brain development
GO:0010659	cardiac muscle cell apoptosis
GO:0006952	defense response
GO:0006309	DNA fragmentation involved in apoptosis
GO:0030900	forebrain development
GO:0006917	induction of apoptosis
GO:0007275	multicellular organismal development
GO:0001843	neural tube closure
GO:0051402	neuron apoptosis
GO:0010952	positive regulation of peptidase activity
GO:0051260	protein homooligomerization
GO:0042981	regulation of apoptosis

Cellular Component

GO:0043293	apoptosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005794	Golgi apparatus
GO:0005622	intracellular
GO:0005634	nucleus

Molecular Function

GO:0043531	ADP binding
GO:0005524	ATP binding
GO:0008656	caspase activator activity
GO:0031072	heat shock protein binding
GO:0042802	identical protein binding
GO:0000166	nucleotide binding

apoptotic peptidase activating factor 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function