CASP8 and FADD-like apoptosis regulator

Synonym

I-FLICE, Flip, Cash, CASH, c-Flip, Caspase homolog, FADD-like antiapoptotic molecule 1, MACH-related inducer of toxicity, Casper, Cellular FLICE-like inhibitory protein, Usurpin, MGC103395, CLARP, Caspase-like apoptosis regulatory protein, Caspase-eight-related protein, CASP8 and FADD-like apoptosis regulator, Cflar, CASP8 and FADD-like apoptosis regulator precursor, c-FLIP, MRIT, Inhibitor of FLICE, FLAME, FLAME-1

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:24.30

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:95.50

spine:-

retina:32.10

eye:38

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:86.30

spleen:171.20

thymus:207.50

bone marrow:64.10

adipose:-

bone:25

skin:55.40

GeneChip

cerebrum:6.30

cerebellum:6.57

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:7.65

spine:6.61

retina:7.02

eye:6.49

artery/aorta:-

vein:7.99

lymphnode:9.50

peripheral blood:-

spleen:8.91

thymus:-

bone marrow:8.10

adipose:8.38

bone:7.87

skin:7.34

CAGE

cerebrum:2.65

cerebellum:-

brain stem:2.39

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:2.70

retina:-

eye:-

artery/aorta:3.79

vein:-

lymphnode:4.19

peripheral blood:-

spleen:3.09

thymus:3.49

bone marrow:-

adipose:-

bone:3.38

skin:3.15

RNA-seq

cerebrum:0.86

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:41.40

prostate:30.90

ovary:11.50

testis:22.20

heart:18.60

muscle:-

esophagus:-

stomach:32.70

intestine:-

colon:17.60

liver/hepato:63.40

lung:90.40

bladder:66.20

kidney:80.60

pituitary:25.80

thyroid/parathyroid:112.50

adrenal gland:-

pancreas:28.10

breast:62

salivary:-

GeneChip

uterus:7.28

placenta:8.25

prostate:7.66

ovary:8.47

testis:6.43

heart:7.67

muscle:7.71

esophagus:-

stomach:7.28

intestine:8.12

colon:-

liver/hepato:9.03

lung:9.75

bladder:8.45

kidney:9.05

pituitary:7.73

thyroid/parathyroid:-

adrenal gland:8.21

pancreas:7.42

breast:8.19

salivary:7.94

CAGE

uterus:3.53

placenta:3.32

prostate:3.31

ovary:3.75

testis:0.45

heart:-

muscle:-

esophagus:-

stomach:3.51

intestine:3.50

colon:3.56

liver/hepato:4.05

lung:4.01

bladder:3.39

kidney:-

pituitary:3.49

thyroid/parathyroid:-

adrenal gland:3.83

pancreas:3.49

breast:3.56

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.63

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:5.11

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_207653
Gene ID	12633
Unigene ID	Mm.336848
Probe set ID	1425686_at [Mouse430_2]
Ensembl ID	ENSMUSG00000026031

Orthologous Gene

Human[18]	NM_001127183, NM_001127184, NM_001202515, NM_001202516, NM_001202517, NM_001202518, NM_001202519, NM_003879
Rat[2]	NM_001033864, NM_057138, NM_001202515, NM_001202516, NM_001202517, NM_001202518, NM_001202519, NM_003879

Chromosomal Region

Gene Family (Interpro ID)

IPR001875	Death effector
IPR011029	DEATH-like
IPR011600	Peptidase C14, caspase catalytic
IPR015917	Peptidase C14, caspase precursor p45, core

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0043066	negative regulation of apoptosis
GO:0043154	negative regulation of caspase activity
GO:0043085	positive regulation of catalytic activity

Cellular Component

GO:0031265	CD95 death-inducing signaling complex
GO:0005737	cytoplasm
GO:0031264	death-inducing signaling complex

Molecular Function

GO:0008047	enzyme activator activity
GO:0002020	protease binding

CASP8 and FADD-like apoptosis regulator

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function