corticotropin releasing hormone receptor 2

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Synonym

CRF 2 receptor, CRF-RB, CRF-R 2, Crfr2, Crhr2, CRF2, CRFR2beta, CRH-R 2, CRFR2alpha, corticotropin releasing hormone receptor 2, CRH-R2, Crf2r, Corticotropin-releasing hormone receptor 2, CRF-R2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:9.90 bone marrow:- adipose:- bone:- skin:7.90
GeneChip cerebrum:4.49 cerebellum:4.46 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.56 spine:4.47 retina:4.93 eye:4.36 artery/aorta:- vein:4.25 lymphnode:4.40 peripheral blood:- spleen:4.41 thymus:- bone marrow:4.32 adipose:4.84 bone:4.45 skin:4.69
CAGE cerebrum:0.31 cerebellum:- brain stem:0 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.32 retina:- eye:- artery/aorta:1.01 vein:- lymphnode:0.23 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:- bone:1.51 skin:1.34
RNA-seq cerebrum:1.27 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:93 muscle:71 esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:6.50 salivary:-
GeneChip uterus:4.18 placenta:4.72 prostate:4.75 ovary:4.19 testis:4.40 heart:5.59 muscle:7.05 esophagus:- stomach:4.35 intestine:4.30 colon:- liver/hepato:4.37 lung:4.47 bladder:4.43 kidney:4.47 pituitary:4.51 thyroid/parathyroid:- adrenal gland:4 pancreas:4.55 breast:5.33 salivary:4.65
CAGE uterus:0 placenta:0 prostate:0.20 ovary:0 testis:0 heart:- muscle:- esophagus:- stomach:0.67 intestine:0 colon:0     liver/hepato:0    lung:0.17 bladder:0 kidney:- pituitary:0 thyroid/parathyroid:- adrenal gland:0 pancreas:0 breast:0.32 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.43 esophagus:- stomach:- intestine:- colon:-     liver/hepato:0        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_009953
Gene ID 12922
Unigene ID Mm.236081
Probe set ID 1422012_at  [Mouse430_2]
Ensembl ID ENSMUSG00000003476

Orthologous Gene

Human[2]  NM_001202475, NM_001202481, NM_001202482, NM_001202483, NM_001883
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR003051  GPCR, family 2, corticotropin releasing factor receptor
IPR003053  GPCR, family 2, corticotropin releasing factor receptor, type 2
IPR002001  GPCR, family 2, diuretic hormone receptor
IPR000832  GPCR, family 2, secretin-like
IPR017981  GPCR, family 2-like

Link to Pubmed  (Pubmed ID)

7565810
7708757
7755719
9383293
10349636
10742107
10742108
10742109
10765562
11042159
11076861
11217851
11337086
11415940
11416224
11517194
11606463
11756502
12032352
12466851
12477932
12554761
12637030
12746321
12786991
12832554
12895416
14670995
14673008
14736736
14990799
15001778
15081583
15256278
15269266
15514029
15701705
15836912
16141072
16141073
16413121
16423327
16492754
16507004
16602821
16769145
16855006
16920976
16955482
16957071
17175507
17194724
17444496
17517441
17626629
17640992
17953621
18155095
18166336
18227763
18288089
18308934
18418662
18443956
18511879
18591672
18670748
18701679
18817761
18843268
19020499
19077175
19246489
19302188
19342454
19520785
19968503
20032050
20052275
20109547
20206175
20392192
20466421
20610744
20731720
21050473
21084379
21627635
21667214
21677750
21704697
21722209
21774994
21946917
22046429
22067315
22083217
22209828
22451915
22593059
22893724
23834894
23835907
24015170
24083959

Gene Ontology  (GO ID)

Biological Process

GO:0007015  actin filament organization
GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0042423  catecholamine biosynthetic process
GO:0007166  cell surface receptor linked signal transduction
GO:0071376  cellular response to corticotropin-releasing hormone stimulus
GO:0030855  epithelial cell differentiation
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0009755  hormone-mediated signaling pathway
GO:0060291  long-term synaptic potentiation
GO:0016525  negative regulation of angiogenesis
GO:0030818  negative regulation of cAMP biosynthetic process
GO:0043951  negative regulation of cAMP-mediated signaling
GO:0032811  negative regulation of epinephrine secretion
GO:0046882  negative regulation of follicle-stimulating hormone secretion
GO:0010629  negative regulation of gene expression
GO:0033685  negative regulation of luteinizing hormone secretion
GO:0010700  negative regulation of norepinephrine secretion
GO:0045777  positive regulation of blood pressure
GO:0030819  positive regulation of cAMP biosynthetic process
GO:0030816  positive regulation of cAMP metabolic process
GO:0043950  positive regulation of cAMP-mediated signaling
GO:0010628  positive regulation of gene expression
GO:0010460  positive regulation of heart rate
GO:0032755  positive regulation of interleukin-6 production
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0014064  positive regulation of serotonin secretion
GO:0032874  positive regulation of stress-activated MAPK cascade
GO:0070372  regulation of ERK1 and ERK2 cascade
GO:0019233  sensory perception of pain
GO:0007165  signal transduction
GO:0048630  skeletal muscle tissue growth

Cellular Component

GO:0030424  axon
GO:0070852  cell body fiber
GO:0043025  cell soma
GO:0009986  cell surface
GO:0030425  dendrite
GO:0005783  endoplasmic reticulum
GO:0005794  Golgi apparatus
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0043679  nerve terminal
GO:0043204  perikaryon
GO:0005886  plasma membrane
GO:0005791  rough endoplasmic reticulum
GO:0043196  varicosity

Molecular Function

GO:0015056  corticotrophin-releasing factor receptor activity
GO:0043404  corticotropin-releasing hormone receptor activity
GO:0004930  G-protein coupled receptor activity
GO:0005179  hormone activity
GO:0017046  peptide hormone binding
GO:0005515  protein binding
GO:0004871  signal transducer activity
GO:0004888  transmembrane receptor activity