excision repair cross-complementing rodent repair deficiency, complementation group 3

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Synonym

DNA-repair protein complementing XP-B cells, BTF2-p89, Ercc-3, Basic transcription factor 2 89 kDa subunit, Xpbc, XPB, Ercc3, Xpb, DNA excision repair protein ERCC-3, TFIIH 89 kDa subunit

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:53.80 cerebellum:36.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:76.40 spine:94.60 retina:64.30 eye:76 artery/aorta:- vein:- lymphnode:496.90 peripheral blood:57.50 spleen:65.80 thymus:39.50 bone marrow:102.60 adipose:- bone:175.30 skin:87.10
GeneChip cerebrum:7.46 cerebellum:7.52 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.49 spine:7.54 retina:7.93 eye:7.94 artery/aorta:- vein:7.62 lymphnode:8.25 peripheral blood:- spleen:8.13 thymus:- bone marrow:8.14 adipose:8.33 bone:7.99 skin:7.74
CAGE cerebrum:2.94 cerebellum:- brain stem:2.71 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.79 retina:- eye:- artery/aorta:2.09 vein:- lymphnode:3.12 peripheral blood:- spleen:2.52 thymus:2.86 bone marrow:- adipose:- bone:2.19 skin:2.34
RNA-seq cerebrum:5.28 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:41.40 prostate:30.90 ovary:23 testis:59.10 heart:37.20 muscle:35.50 esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:18.10        lung:40.20    bladder:66.20 kidney:56.40 pituitary:51.70 thyroid/parathyroid:112.50 adrenal gland:- pancreas:28.10 breast:39.20 salivary:-
GeneChip uterus:8.28 placenta:8 prostate:8.46 ovary:8.18 testis:9.10 heart:7.27 muscle:7.38 esophagus:- stomach:8.03 intestine:8.34 colon:- liver/hepato:7.88 lung:7.99 bladder:8.10 kidney:7.97 pituitary:7.84 thyroid/parathyroid:- adrenal gland:8.47 pancreas:7.16 breast:7.85 salivary:7.83
CAGE uterus:2.84 placenta:2.68 prostate:2.95 ovary:2.39 testis:3.98 heart:- muscle:- esophagus:- stomach:2.95 intestine:2.87 colon:2.99     liver/hepato:2.95    lung:2.76 bladder:2.94 kidney:- pituitary:2.75 thyroid/parathyroid:- adrenal gland:2.72 pancreas:2.03 breast:2.96 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:6.47 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.59        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_133658
Gene ID 13872
Unigene ID Mm.282335
Probe set ID 1448497_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024382

Orthologous Gene

Human[1]  NM_000122
Rat[1]  NM_001031644

Chromosomal Region

-

Gene Family (Interpro ID)

IPR014001  DEAD-like helicase, N-terminal
IPR014021  Helicase, superfamily 1/2, ATP-binding domain

Link to Pubmed  (Pubmed ID)

1747940
7805288
10349636
10777215
10922068
11042159
11076861
11217851
12466851
12477932
14980221
15489334
15808511
16101586
16141072
16141073
17276355
19114557
19841728
20059953
20498273
22863773
22922362
23562818
24127601
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0000075  cell cycle checkpoint
GO:0006281  DNA repair
GO:0006265  DNA topological change
GO:0035315  hair cell differentiation
GO:0006917  induction of apoptosis
GO:0006289  nucleotide-excision repair
GO:0000717  nucleotide-excision repair, DNA duplex unwinding
GO:0033683  nucleotide-excision repair, DNA incision
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0008104  protein localization
GO:0006355  regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus
GO:0006979  response to oxidative stress
GO:0009411  response to UV
GO:0006366  transcription from RNA polymerase II promoter
GO:0006351  transcription, DNA-dependent
GO:0006283  transcription-coupled nucleotide-excision repair
GO:0009650  UV protection

Cellular Component

GO:0005675  holo TFIIH complex
GO:0005634  nucleus
GO:0000441  SSL2-core TFIIH complex

Molecular Function

GO:0043138  3'-5' DNA helicase activity
GO:0005524  ATP binding
GO:0004003  ATP-dependent DNA helicase activity
GO:0016887  ATPase activity
GO:0032564  dATP binding
GO:0003677  DNA binding
GO:0008094  DNA-dependent ATPase activity
GO:0005525  GTP binding
GO:0004386  helicase activity
GO:0016787  hydrolase activity
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0042277  peptide binding
GO:0008022  protein C-terminus binding
GO:0004672  protein kinase activity
GO:0047485  protein N-terminus binding
GO:0008353  RNA polymerase II carboxy-terminal domain kinase activity