fatty acid synthase

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Synonym

Fasn, fatty acid synthase, Fatty acid synthase, FAS, A630082H08Rik

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1081.90 cerebellum:36.80 brain stem:- corpus callosum/glia:- pineal gland:257.80 peripheral nerve:57.30 spine:141.90 retina:321.40 eye:357.10 artery/aorta:- vein:- lymphnode:356.40 peripheral blood:86.30 spleen:223.80 thymus:49.40 bone marrow:25.60 adipose:- bone:125.20 skin:190
GeneChip cerebrum:9.85 cerebellum:9.17 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:10.58 spine:10.41 retina:7.86 eye:8.43 artery/aorta:- vein:8.99 lymphnode:11.28 peripheral blood:- spleen:8.69 thymus:- bone marrow:8.10 adipose:13.25 bone:8.42 skin:10.64
CAGE cerebrum:4.41 cerebellum:- brain stem:5.03 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:5.29 retina:- eye:- artery/aorta:8.07 vein:- lymphnode:4.13 peripheral blood:- spleen:3.52 thymus:5.38 bone marrow:- adipose:- bone:3.83 skin:5.46
RNA-seq cerebrum:30.73 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:87.20 placenta:317.60 prostate:30.90 ovary:46 testis:206.90 heart:18.60 muscle:35.50 esophagus:- stomach:- intestine:- colon:211.50     liver/hepato:298.70        lung:241    bladder:728 kidney:153.10 pituitary:12.90 thyroid/parathyroid:449.90 adrenal gland:- pancreas:46.90 breast:483.20 salivary:809.90
GeneChip uterus:10.48 placenta:8.14 prostate:9.32 ovary:12.25 testis:8.55 heart:9.68 muscle:9.97 esophagus:- stomach:10.04 intestine:9.43 colon:- liver/hepato:10.72 lung:11.33 bladder:10.02 kidney:9.87 pituitary:9.39 thyroid/parathyroid:- adrenal gland:13.50 pancreas:9.02 breast:12.82 salivary:8.94
CAGE uterus:4.92 placenta:3.49 prostate:4.54 ovary:6.22 testis:3.69 heart:- muscle:- esophagus:- stomach:4.01 intestine:4.23 colon:4.32     liver/hepato:6.97    lung:5.44 bladder:4.70 kidney:- pituitary:4.23 thyroid/parathyroid:- adrenal gland:6.53 pancreas:4.54 breast:8.08 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:15.25 esophagus:- stomach:- intestine:- colon:-     liver/hepato:56.03        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007988
Gene ID 14104
Unigene ID Mm.236443
Probe set ID 1423828_at  [Mouse430_2]
Ensembl ID ENSMUSG00000025153

Orthologous Gene

Human[2]  NM_004104
Rat[2]  NM_004104

Chromosomal Region

-

Gene Family (Interpro ID)

IPR009081  Acyl carrier protein-like
IPR014043  Acyl transferase
IPR001227  Acyl transferase domain
IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
IPR016040  NAD(P)-binding domain
IPR006163  Phosphopantetheine-binding
IPR020801  Polyketide synthase, acyl transferase domain
IPR020806  Polyketide synthase, phosphopantetheine-binding
IPR020842  Polyketide synthase/Fatty acid synthase, KR

Link to Pubmed  (Pubmed ID)

2452820
2920037
7506544
7595075
7803821
8043949
8075499
8661038
8833906
9096121
9271675
9367675
9798653
9890958
9922208
10341080
10349636
10409670
10464095
10725249
10922068
10982846
11029661
11042159
11076861
11217851
11254743
11756683
12376313
12466851
12477932
12520002
12588883
12738878
12897158
12904583
14522948
14610273
14662765
14668353
14681479
15169678
15306695
15489334
15707987
15782199
16054078
16054098
16141072
16141073
16203972
16498401
16894240
17369526
17635921
17694178
17786030
18079124
18591393
18614015
18635971
18682402
18706411
18722179
18770866
19029118
20479009
20606731
20657840
20890301
21093383
21180279
21267068
21281598
21387314
21389266
21677750
21757749
22055502
22096492
22331133
22341463
22922362
23000407
23201681
23260145
23269672
23376793
23637738
23675653
23727646
24457600
24668799

Gene Ontology  (GO ID)

Biological Process

GO:0009058  biosynthetic process
GO:0071353  cellular response to interleukin-4
GO:0006633  fatty acid biosynthetic process
GO:0006631  fatty acid metabolic process
GO:0006629  lipid metabolic process
GO:0008152  metabolic process
GO:0055114  oxidation reduction

Cellular Component

GO:0005737  cytoplasm
GO:0042587  glycogen granule
GO:0005794  Golgi apparatus
GO:0005739  mitochondrion
GO:0005886  plasma membrane

Molecular Function

GO:0019171  3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
GO:0047451  3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:0004317  3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:0004316  3-oxoacyl-[acyl-carrier-protein] reductase activity
GO:0004315  3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0016297  acyl-[acyl-carrier-protein] hydrolase activity
GO:0003824  catalytic activity
GO:0004319  enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
GO:0004312  fatty-acid synthase activity
GO:0016787  hydrolase activity
GO:0016788  hydrolase activity, acting on ester bonds
GO:0016829  lyase activity
GO:0016295  myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0004320  oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0016491  oxidoreductase activity
GO:0016296  palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0016740  transferase activity
GO:0016746  transferase activity, transferring acyl groups
GO:0016747  transferase activity, transferring acyl groups other than amino-acyl groups
GO:0008270  zinc ion binding
GO:0004313  [acyl-carrier-protein] S-acetyltransferase activity
GO:0004314  [acyl-carrier-protein] S-malonyltransferase activity