glycosylphosphatidylinositol specific phospholipase D1

 jump to detail

Synonym

AW546131, Glycoprotein phospholipase D, Gpld1, PI-G PLD, 6330541J12Rik

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:57.30 cerebellum:92.10 brain stem:63.60 corpus callosum/glia:- pineal gland:- peripheral nerve:133.80 spine:141.90 retina:96.40 eye:30.40 artery/aorta:84.40 vein:- lymphnode:- peripheral blood:- spleen:26.30 thymus:29.60 bone marrow:- adipose:- bone:25 skin:71.30
GeneChip cerebrum:8.47 cerebellum:8.64 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.19 spine:9.86 retina:8.49 eye:6.99 artery/aorta:- vein:8.64 lymphnode:5.89 peripheral blood:- spleen:5.48 thymus:- bone marrow:5.79 adipose:7.63 bone:6.83 skin:9.35
CAGE cerebrum:3.20 cerebellum:- brain stem:4.03 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.28 retina:- eye:- artery/aorta:0.25 vein:- lymphnode:0 peripheral blood:- spleen:0 thymus:0.27 bone marrow:- adipose:- bone:0 skin:2.17
RNA-seq cerebrum:9.58 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:30.90 ovary:11.50 testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:280.60        lung:-    bladder:- kidney:8.10 pituitary:- thyroid/parathyroid:- adrenal gland:848.90 pancreas:18.80 breast:19.60 salivary:54
GeneChip uterus:6.80 placenta:6.28 prostate:9.97 ovary:6.96 testis:6.61 heart:6.61 muscle:5.97 esophagus:- stomach:9.06 intestine:7.06 colon:- liver/hepato:11.54 lung:7.39 bladder:8.57 kidney:6.25 pituitary:8.93 thyroid/parathyroid:- adrenal gland:7.06 pancreas:7.85 breast:6.18 salivary:7.87
CAGE uterus:0 placenta:0.10 prostate:2.98 ovary:0.13 testis:0 heart:- muscle:- esophagus:- stomach:2.44 intestine:0 colon:0     liver/hepato:5.35    lung:0.44 bladder:0.68 kidney:- pituitary:3.44 thyroid/parathyroid:- adrenal gland:1.26 pancreas:0.84 breast:0 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:29.49        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008156
Gene ID 14756
Unigene ID Mm.291831
Probe set ID 1418050_at  [Mouse430_2]
Ensembl ID ENSMUSG00000021340

Orthologous Gene

Human[5]  NM_001503, NM_177483
Rat[1]  NM_001100512, NM_177483

Chromosomal Region

-

Gene Family (Interpro ID)

IPR013517  FG-GAP
IPR013519  Integrin alpha beta-propellor

Link to Pubmed  (Pubmed ID)

1833386
9182575
9716655
9832456
9892740
10349636
10856884
10922068
11042159
11076861
11217851
12090469
12466851
12477932
14681479
14719799
15194230
15943582
15946906
16141072
16141073
16219662
16822939
16944957
17330941
17720976
20153004
21267068
23055941

Gene Ontology  (GO ID)

Biological Process

GO:0002042  cell migration involved in sprouting angiogenesis
GO:0071277  cellular response to calcium ion
GO:0071397  cellular response to cholesterol
GO:0071241  cellular response to inorganic substance
GO:0032869  cellular response to insulin stimulus
GO:0071282  cellular response to iron(II) ion
GO:0071467  cellular response to pH
GO:0071401  cellular response to triglyceride
GO:0002430  complement receptor mediated signaling pathway
GO:0006507  GPI anchor release
GO:0008286  insulin receptor signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0010897  negative regulation of triglyceride catabolic process
GO:0043065  positive regulation of apoptosis
GO:0045919  positive regulation of cytolysis
GO:0010595  positive regulation of endothelial cell migration
GO:0010907  positive regulation of glucose metabolic process
GO:0010983  positive regulation of high-density lipoprotein particle clearance
GO:0051044  positive regulation of membrane protein ectodomain proteolysis
GO:0051047  positive regulation of secretion
GO:0010867  positive regulation of triglyceride biosynthetic process
GO:0009749  response to glucose stimulus
GO:0070633  transepithelial transport

Cellular Component

GO:0005737  cytoplasm
GO:0044444  cytoplasmic part
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0034364  high-density lipoprotein particle
GO:0005622  intracellular
GO:0043231  intracellular membrane-bounded organelle
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0004621  glycosylphosphatidylinositol phospholipase D activity
GO:0016787  hydrolase activity
GO:0004630  phospholipase D activity
GO:0017080  sodium channel regulator activity