glutamate receptor, ionotropic, kainate 2 (beta 2)

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Synonym

Glur-6, AW124492, Glur6, Glutamate receptor 6, GluR-6, Grik2, Glutamate receptor, ionotropic kainate 2 precursor, Glutamate receptor beta-2, GluR6, GluR beta-2, glutamate receptor, ionotropic, kainate 2 (beta 2)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:38.20 cerebellum:147.40 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:7.60 artery/aorta:84.40 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.92 cerebellum:7.27 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.20 spine:5.70 retina:4.78 eye:4.86 artery/aorta:- vein:5.45 lymphnode:4.41 peripheral blood:- spleen:4.30 thymus:- bone marrow:4.65 adipose:4.39 bone:4.49 skin:4.20
CAGE cerebrum:5.06 cerebellum:- brain stem:4.08 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.97 retina:- eye:- artery/aorta:1.24 vein:- lymphnode:0.57 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:- bone:0 skin:0.91
RNA-seq cerebrum:1.76 cerebellum:1.76 brain stem:1.76 corpus callosum/glia:1.76 pineal gland:1.76 peripheral nerve:1.76 spine:1.76 retina:1.76 eye:1.76 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:6.50 salivary:-
GeneChip uterus:4.32 placenta:4.60 prostate:4.64 ovary:4.33 testis:6.14 heart:4.81 muscle:4.59 esophagus:- stomach:4.57 intestine:4.33 colon:- liver/hepato:4.84 lung:4.21 bladder:4.69 kidney:4.57 pituitary:5.62 thyroid/parathyroid:- adrenal gland:5.05 pancreas:4.66 breast:4.39 salivary:4.96
CAGE uterus:1.41 placenta:0.44 prostate:0.63 ovary:0.62 testis:0 heart:- muscle:- esophagus:- stomach:0.67 intestine:0.42 colon:0.23     liver/hepato:0.26    lung:0.83 bladder:1.36 kidney:- pituitary:4.29 thyroid/parathyroid:- adrenal gland:2.26 pancreas:0 breast:0.42 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001111268
Gene ID 14806
Unigene ID Mm.332838
Probe set ID 1425790_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000056073

Orthologous Gene

Human[3]  NM_001166247, NM_021956, NM_175768
Rat [0]  

Chromosomal Region

10B3  [48,819,266  -  49,508,572]

Gene Family (Interpro ID)

IPR001320  Ionotropic glutamate receptor
IPR001508  NMDA receptor

Link to Pubmed  (Pubmed ID)

1310861
1379666
1717158
7523595
7681676
8260617
8464923
8700852
8889548
9016303
9021139
9051806
9108071
9141074
9490692
9580260
9593973
9651535
9880586
10349636
10479699
10575223
10704492
11042159
11069933
11076861
11144357
11182092
11182093
11217851
11985817
12151522
12223554
12466851
12477932
12947409
12954862
14724198
15014126
15064766
15328020
15358807
15483117
15509753
15513934
15537878
15539395
15673679
15774535
15805114
15928066
16102538
16141072
16141073
16219388
16354929
16987237
17108093
17174564
17254796
17428973
17620617
17650106
18001285
18332879
18358623
18448566
18641643
18793656
18799693
19020026
19217376
19263192
19369569
19596362
20081851
21267068
21623363
21734292
22241839
22534482
22723691
23076118
23223307
23861400
24760837

Gene Ontology  (GO ID)

Biological Process

GO:0001662  behavioral fear response
GO:0006874  cellular calcium ion homeostasis
GO:0006886  intracellular protein transport
GO:0006811  ion transport
GO:0035235  ionotropic glutamate receptor signaling pathway
GO:0043524  negative regulation of neuron apoptosis
GO:0051967  negative regulation of synaptic transmission, glutamatergic
GO:0051402  neuron apoptosis
GO:0043525  positive regulation of neuron apoptosis
GO:0050806  positive regulation of synaptic transmission
GO:0043113  receptor clustering
GO:0019228  regulation of action potential in neuron
GO:0060079  regulation of excitatory postsynaptic membrane potential
GO:0060080  regulation of inhibitory postsynaptic membrane potential
GO:0046328  regulation of JNK cascade
GO:0048169  regulation of long-term neuronal synaptic plasticity
GO:0042391  regulation of membrane potential
GO:0048172  regulation of short-term neuronal synaptic plasticity
GO:0050804  regulation of synaptic transmission
GO:0007268  synaptic transmission
GO:0035249  synaptic transmission, glutamatergic
GO:0006810  transport

Cellular Component

GO:0030424  axon
GO:0030054  cell junction
GO:0043025  cell soma
GO:0030425  dendrite
GO:0032839  dendrite cytoplasm
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0008328  ionotropic glutamate receptor complex
GO:0032983  kainate selective glutamate receptor complex
GO:0016020  membrane
GO:0043204  perikaryon
GO:0005886  plasma membrane
GO:0045211  postsynaptic membrane
GO:0042734  presynaptic membrane
GO:0045202  synapse
GO:0043195  terminal button

Molecular Function

GO:0005234  extracellular-glutamate-gated ion channel activity
GO:0008066  glutamate receptor activity
GO:0042802  identical protein binding
GO:0005216  ion channel activity
GO:0004970  ionotropic glutamate receptor activity
GO:0015277  kainate selective glutamate receptor activity
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004872  receptor activity
GO:0031624  ubiquitin conjugating enzyme binding
GO:0031625  ubiquitin protein ligase binding