high mobility group AT-hook 2

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Synonym

High mobility group protein HMGI-C, HMGI-C, 9430083A20Rik, MGC103393, Hmga2, High mobility group AT-hook protein 2, pg, pygmy, high mobility group AT-hook 2, Hmgic

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:79.90 cerebellum:- brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:76.40 spine:94.60 retina:128.60 eye:68.40 artery/aorta:- vein:- lymphnode:10.80 peripheral blood:316.30 spleen:- thymus:9.90 bone marrow:38.50 adipose:- bone:125.20 skin:87.10
GeneChip cerebrum:4.23 cerebellum:4.35 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.24 spine:4.28 retina:4.59 eye:4.64 artery/aorta:- vein:5.39 lymphnode:4.33 peripheral blood:- spleen:4.39 thymus:- bone marrow:4.49 adipose:4.43 bone:4.46 skin:4.58
CAGE cerebrum:0.24 cerebellum:- brain stem:0.20 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.75 retina:- eye:- artery/aorta:0 vein:- lymphnode:0 peripheral blood:- spleen:0.16 thymus:0 bone marrow:- adipose:- bone:0.63 skin:0.77
RNA-seq cerebrum:0.44 cerebellum:0.44 brain stem:0.44 corpus callosum/glia:0.44 pineal gland:0.44 peripheral nerve:0.44 spine:0.44 retina:0.44 eye:0.44 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:828.90 placenta:- prostate:- ovary:68.90 testis:59.10 heart:- muscle:213 esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:36.20        lung:110.50    bladder:- kidney:24.20 pituitary:310 thyroid/parathyroid:- adrenal gland:- pancreas:65.70 breast:9.80 salivary:-
GeneChip uterus:6.90 placenta:4.49 prostate:4.35 ovary:5.55 testis:4.72 heart:4.25 muscle:4.32 esophagus:- stomach:6.11 intestine:5.74 colon:- liver/hepato:4.38 lung:4.29 bladder:4.13 kidney:4.30 pituitary:4.27 thyroid/parathyroid:- adrenal gland:5.23 pancreas:4.48 breast:4.26 salivary:4.46
CAGE uterus:3.65 placenta:2.15 prostate:0.20 ovary:2.37 testis:0 heart:- muscle:- esophagus:- stomach:2.73 intestine:2.79 colon:2.27     liver/hepato:0.26    lung:0 bladder:0 kidney:- pituitary:0.86 thyroid/parathyroid:- adrenal gland:1.82 pancreas:0 breast:0 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010441
Gene ID 15364
Unigene ID Mm.157190
Probe set ID 1422851_at  [Mouse430_2]
Ensembl ID ENSMUSG00000056758

Orthologous Gene

Human[2]  NM_003483, NM_003484
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR020478  A.T hook-like
IPR017956  AT hook, DNA-binding motif
IPR000116  High mobility group, HMG-I/HMG-Y

Link to Pubmed  (Pubmed ID)

504232
1311971
1508193
1685136
1698554
1762909
1924386
1975791
2305264
5051369
7390396
7615634
7651535
7795651
7849395
7958830
8100556
8535068
8566786
8718494
8918814
9545312
9824208
10349636
10395190
10636877
10742101
10922068
11042159
11076861
11181445
11217851
11427729
11438738
11555636
11801530
11805063
12032866
12082634
12466851
12477932
12799440
13679031
14571323
14595844
14610273
14645522
14668482
14794889
15225648
15489334
15618518
15645444
16007198
16109425
16141072
16141073
16293633
16765103
16766265
16831886
17305714
17322030
17332316
18238902
18287559
18425117
18554416
18640244
18832382
18957199
19004856
19070572
19223528
19228596
19303107
19320717
19521500
20007691
20059953
20123068
20412781
21267068
21417337
22639370
22726539
22797695
22991445
23072816
23177649
23184966
23318420
23625920
23630078
23639551
23716660
23722545
23811688
23895693
23940373
24192035
24305048

Gene Ontology  (GO ID)

Biological Process

GO:0060612  adipose tissue development
GO:0030325  adrenal gland development
GO:0006284  base-excision repair
GO:0007049  cell cycle
GO:0051301  cell division
GO:0021846  cell proliferation in forebrain
GO:0002062  chondrocyte differentiation
GO:0031052  chromosome breakage
GO:0030261  chromosome condensation
GO:0042769  DNA damage response, detection of DNA damage
GO:0001837  epithelial to mesenchymal transition
GO:0045444  fat cell differentiation
GO:0060613  fat pad development
GO:0031507  heterochromatin formation
GO:0008584  male gonad development
GO:0007126  meiosis
GO:0048762  mesenchymal cell differentiation
GO:0048333  mesodermal cell differentiation
GO:0003131  mesodermal-endodermal cell signaling
GO:0007067  mitosis
GO:0007095  mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0043922  negative regulation by host of viral transcription
GO:0043066  negative regulation of apoptosis
GO:0048712  negative regulation of astrocyte differentiation
GO:0043392  negative regulation of DNA binding
GO:0046426  negative regulation of JAK-STAT cascade
GO:0045869  negative regulation of retroviral genome replication
GO:0033144  negative regulation of steroid hormone receptor signaling pathway
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0021983  pituitary gland development
GO:0043065  positive regulation of apoptosis
GO:0071158  positive regulation of cell cycle arrest
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0040018  positive regulation of multicellular organism growth
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0010564  regulation of cell cycle process
GO:0040008  regulation of growth
GO:0060123  regulation of growth hormone secretion
GO:0006355  regulation of transcription, DNA-dependent
GO:0007165  signal transduction
GO:0035019  somatic stem cell maintenance
GO:0007283  spermatogenesis
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0000785  chromatin
GO:0000228  nuclear chromosome
GO:0005634  nucleus
GO:0032993  protein-DNA complex
GO:0071141  SMAD protein complex

Molecular Function

GO:0051575  5'-deoxyribose-5-phosphate lyase activity
GO:0003680  AT DNA binding
GO:0070742  C2H2 zinc finger domain binding
GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0003906  DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004677  DNA-dependent protein kinase activity
GO:0019899  enzyme binding
GO:0031492  nucleosomal DNA binding
GO:0005515  protein binding
GO:0046332  SMAD binding
GO:0008134  transcription factor binding