lipase, hepatic

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Synonym

Hpl, AI256194, Hepatic lipase, HL, Hepatic triacylglycerol lipase precursor, Lipc, lipase, hepatic

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:95.50 spine:94.60 retina:- eye:15.20 artery/aorta:- vein:- lymphnode:21.60 peripheral blood:- spleen:39.50 thymus:39.50 bone marrow:- adipose:- bone:100.20 skin:-
GeneChip cerebrum:4.28 cerebellum:4.08 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.27 spine:4.12 retina:4.39 eye:4.97 artery/aorta:- vein:4.30 lymphnode:4.77 peripheral blood:- spleen:5.41 thymus:- bone marrow:4.71 adipose:4.83 bone:6.37 skin:3.97
CAGE cerebrum:0 cerebellum:- brain stem:0 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.17 retina:- eye:- artery/aorta:0 vein:- lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:- bone:0 skin:0
RNA-seq cerebrum:1.54 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:190.10        lung:30.10    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:18.80 breast:- salivary:-
GeneChip uterus:3.92 placenta:4.77 prostate:4.12 ovary:4.04 testis:4.31 heart:4.63 muscle:4.43 esophagus:- stomach:4.37 intestine:4.35 colon:- liver/hepato:10.86 lung:5.44 bladder:4.43 kidney:4.51 pituitary:4.76 thyroid/parathyroid:- adrenal gland:4.17 pancreas:5.14 breast:4.27 salivary:4.52
CAGE uterus:0.17 placenta:0.84 prostate:0 ovary:0 testis:0 heart:- muscle:- esophagus:- stomach:0.67 intestine:0 colon:0.23     liver/hepato:5.97    lung:0 bladder:0.33 kidney:- pituitary:0 thyroid/parathyroid:- adrenal gland:1.07 pancreas:0.84 breast:0 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:31.19        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008280
Gene ID 15450
Unigene ID Mm.390187
Probe set ID 1419560_at  [Mouse430_2]
Ensembl ID ENSMUSG00000032207

Orthologous Gene

Human[1]  NM_000236
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR002333  Hepatic lipase
IPR000734  Lipase
IPR008976  Lipase/lipooxygenase, PLAT/LH2
IPR016272  Lipoprotein lipase, LIPH
IPR001024  Lipoxygenase, LH2

Link to Pubmed  (Pubmed ID)

1840530
2025643
2563260
3109891
3470738
6804942
6812053
7852377
8105016
8288233
8560269
8672141
8798380
8827514
9153204
9338114
9606417
9616220
9630674
9717727
9861024
9918035
10349636
10357838
10482304
10744773
10787427
11042159
11076861
11208732
11217851
11290828
11842132
11906928
11971936
12117557
12466851
12477932
12700335
12897204
12939599
12975454
14610273
14679168
14681479
14974682
14981222
15181537
15205216
15304509
15314098
15520453
15995171
16141072
16141073
16368783
16397139
16498401
17071916
17103052
17234195
17431181
17872590
18175806
18599739
19136429
19524061
19783858
19965617
20056822
20373033
20558822
21267068
21677750
21730028
21750705
22323595
23328279
23355893
23376223
24440515

Gene Ontology  (GO ID)

Biological Process

GO:0042632  cholesterol homeostasis
GO:0008203  cholesterol metabolic process
GO:0030301  cholesterol transport
GO:0034382  chylomicron remnant clearance
GO:0034371  chylomicron remodeling
GO:0006633  fatty acid biosynthetic process
GO:0006631  fatty acid metabolic process
GO:0046475  glycerophospholipid catabolic process
GO:0015012  heparan sulfate proteoglycan biosynthetic process
GO:0034375  high-density lipoprotein particle remodeling
GO:0016042  lipid catabolic process
GO:0006629  lipid metabolic process
GO:0034383  low-density lipoprotein particle clearance
GO:0034374  low-density lipoprotein particle remodeling
GO:0008152  metabolic process
GO:0016071  mRNA metabolic process
GO:0046461  neutral lipid catabolic process
GO:0046473  phosphatidic acid metabolic process
GO:0046470  phosphatidylcholine metabolic process
GO:0046337  phosphatidylethanolamine metabolic process
GO:0006658  phosphatidylserine metabolic process
GO:0051259  protein oligomerization
GO:0019433  triglyceride catabolic process
GO:0070328  triglyceride homeostasis
GO:0006641  triglyceride metabolic process
GO:0034372  very-low-density lipoprotein particle remodeling

Cellular Component

GO:0009986  cell surface
GO:0005769  early endosome
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0034364  high-density lipoprotein particle
GO:0005770  late endosome
GO:0005902  microvillus

Molecular Function

GO:0047372  acylglycerol lipase activity
GO:0034185  apolipoprotein binding
GO:0004091  carboxylesterase activity
GO:0003824  catalytic activity
GO:0043395  heparan sulfate proteoglycan binding
GO:0008201  heparin binding
GO:0016787  hydrolase activity
GO:0016298  lipase activity
GO:0008289  lipid binding
GO:0030169  low-density lipoprotein binding
GO:0004622  lysophospholipase activity
GO:0008970  phospholipase A1 activity
GO:0005515  protein binding
GO:0050253  retinyl-palmitate esterase activity
GO:0016746  transferase activity, transferring acyl groups
GO:0004806  triglyceride lipase activity