insulin degrading enzyme

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Synonym

AI507533, Ide, Insulysin, 1300012G03Rik, Insulinase, 4833415K22Rik, AA675336, Insulin-degrading enzyme, Insulin protease, insulin degrading enzyme

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:66 cerebellum:110.50 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:47.30 retina:64.30 eye:152 artery/aorta:84.40 vein:- lymphnode:21.60 peripheral blood:273.20 spleen:105.30 thymus:138.30 bone marrow:38.50 adipose:- bone:75.10 skin:253.40
GeneChip cerebrum:8.77 cerebellum:9.41 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.68 spine:9.20 retina:9.52 eye:9.68 artery/aorta:- vein:10.50 lymphnode:9.03 peripheral blood:- spleen:9.14 thymus:- bone marrow:9.24 adipose:9.94 bone:9.27 skin:11.72
CAGE cerebrum:0 cerebellum:- brain stem:0 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:- lymphnode:0 peripheral blood:- spleen:0 thymus:0.27 bone marrow:- adipose:- bone:0 skin:4.59
RNA-seq cerebrum:3.82 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:130.90 placenta:96.70 prostate:123.50 ovary:23 testis:266 heart:130.20 muscle:35.50 esophagus:- stomach:- intestine:- colon:52.90     liver/hepato:99.60        lung:60.30    bladder:66.20 kidney:56.40 pituitary:51.70 thyroid/parathyroid:112.50 adrenal gland:- pancreas:65.70 breast:78.40 salivary:-
GeneChip uterus:9.49 placenta:9.08 prostate:9.88 ovary:9.99 testis:11.22 heart:9.89 muscle:10.46 esophagus:- stomach:10.72 intestine:9.44 colon:- liver/hepato:10.56 lung:9.43 bladder:9.88 kidney:10.07 pituitary:9.30 thyroid/parathyroid:- adrenal gland:10.16 pancreas:9.83 breast:9.49 salivary:10.56
CAGE uterus:0.31 placenta:0.44 prostate:0 ovary:0.45 testis:0 heart:- muscle:- esophagus:- stomach:4.28 intestine:0.84 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:- pituitary:0 thyroid/parathyroid:- adrenal gland:0 pancreas:0 breast:0 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:6.28 esophagus:- stomach:- intestine:- colon:-     liver/hepato:10.13        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_031156
Gene ID 15925
Unigene ID Mm.28366
Probe set ID 1423120_at  [Mouse430_2]
Ensembl ID ENSMUSG00000056999

Orthologous Gene

Human[6]  NM_001165946, NM_004969
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1358795
1460423
2293021
8499657
8889548
10349636
11042159
11076861
11217851
12466851
12477932
12520002
12634421
12732730
12850277
14610273
14681479
15590928
15800373
16141072
16141073
16292511
16602821
17143549
18032724
18287559
18455870
18554416
18614015
18799693
19334288
20061628
20876579
21267068
21491542
21576244
21677750
21695259
21873424
22227962
22509294
22586115
23200833
23349488
23684818
23912999

Gene Ontology  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0050435  beta-amyloid metabolic process
GO:0010815  bradykinin catabolic process
GO:0044257  cellular protein catabolic process
GO:0008340  determination of adult lifespan
GO:0042447  hormone catabolic process
GO:0008152  metabolic process
GO:0045861  negative regulation of proteolysis
GO:0032461  positive regulation of protein oligomerization
GO:0051291  protein heterooligomerization
GO:0051260  protein homooligomerization
GO:0051289  protein homotetramerization
GO:0006508  proteolysis
GO:0051603  proteolysis involved in cellular protein catabolic process
GO:0010992  ubiquitin homeostasis

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0031597  cytosolic proteasome complex
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016020  membrane
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0005782  peroxisomal matrix
GO:0005777  peroxisome
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0016887  ATPase activity
GO:0001540  beta-amyloid binding
GO:0031626  beta-endorphin binding
GO:0003824  catalytic activity
GO:0001948  glycoprotein binding
GO:0016787  hydrolase activity
GO:0043559  insulin binding
GO:0046872  metal ion binding
GO:0004222  metalloendopeptidase activity
GO:0008237  metallopeptidase activity
GO:0000166  nucleotide binding
GO:0008233  peptidase activity
GO:0042277  peptide binding
GO:0017046  peptide hormone binding
GO:0042803  protein homodimerization activity
GO:0005102  receptor binding
GO:0043130  ubiquitin binding
GO:0008270  zinc ion binding