interleukin 6 receptor, alpha

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Synonym

interleukin 6 receptor, alpha, IL-6R-alpha, Il6r, Il6ra, CD126, IL-6 receptor alpha chain, CD126 antigen, IL-6R, IL-6R 1, Interleukin-6 receptor alpha chain precursor, MGC30256

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:6.90 cerebellum:18.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:- retina:- eye:7.60 artery/aorta:- vein:- lymphnode:- peripheral blood:14.40 spleen:- thymus:29.60 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.26 cerebellum:5.06 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.88 spine:5.40 retina:5.02 eye:5.54 artery/aorta:- vein:6.65 lymphnode:8.62 peripheral blood:- spleen:8.63 thymus:- bone marrow:8.33 adipose:7.02 bone:7.99 skin:9.47
CAGE cerebrum:1.32 cerebellum:- brain stem:1.56 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.47 retina:- eye:- artery/aorta:3.28 vein:- lymphnode:3.77 peripheral blood:- spleen:3.19 thymus:2.07 bone marrow:- adipose:- bone:3.54 skin:4.08
RNA-seq cerebrum:1.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:27.60 prostate:- ovary:11.50 testis:177.40 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.80 salivary:-
GeneChip uterus:6.15 placenta:8.44 prostate:6.32 ovary:6.31 testis:5.24 heart:6.24 muscle:6.42 esophagus:- stomach:5.90 intestine:5.80 colon:- liver/hepato:8.55 lung:7.83 bladder:7.06 kidney:5.77 pituitary:7.31 thyroid/parathyroid:- adrenal gland:7.03 pancreas:7.65 breast:6.95 salivary:6.38
CAGE uterus:2.67 placenta:3.86 prostate:2.39 ovary:2.48 testis:0.45 heart:- muscle:- esophagus:- stomach:1.91 intestine:1.36 colon:1.93     liver/hepato:4.17    lung:3.76 bladder:2.82 kidney:- pituitary:2.85 thyroid/parathyroid:- adrenal gland:2.38 pancreas:3.21 breast:3.80 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.27 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.96        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010559
Gene ID 16194
Unigene ID Mm.285609
Probe set ID 1452416_at  [Mouse430_2]
Ensembl ID ENSMUSG00000027947

Orthologous Gene

Human[4]  NM_000565, NM_001206866, NM_181359
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold

Link to Pubmed  (Pubmed ID)

1312474
2051018
2112585
7621883
8392875
8477802
8499630
8676083
8770556
8797792
8836549
9034153
9324354
9659221
9708822
9743535
9874564
10349636
10521784
11042159
11073809
11076861
11197687
11217851
11275690
11937300
12370259
12413742
12429018
12466851
12477932
12643284
14610273
14960573
15073037
15191552
15457342
16034137
16141072
16141073
16435023
16602821
17202339
17567983
18156493
18555695
19420002
19714627
19933857
20026129
20042582
20083667
20351184
20483735
20691261
20816090
20817879
21267068
21454673
21464300
21511185
21960530
21990364
22295972
22467660
22758208
23085146
23209286
23297399
23378927
23564454
23696660
23935104
23954788
24047696
24209760
24412616
24681566

Gene Ontology  (GO ID)

Biological Process

GO:0016049  cell growth
GO:0070120  ciliary neurotrophic factor-mediated signaling pathway
GO:0019221  cytokine-mediated signaling pathway
GO:0031018  endocrine pancreas development
GO:0070102  interleukin-6-mediated signaling pathway
GO:0032966  negative regulation of collagen biosynthetic process
GO:0010536  positive regulation of activation of Janus kinase activity
GO:0008284  positive regulation of cell proliferation
GO:0032722  positive regulation of chemokine production
GO:0032755  positive regulation of interleukin-6 production
GO:0046427  positive regulation of JAK-STAT cascade
GO:0043410  positive regulation of MAPKKK cascade
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0034097  response to cytokine stimulus

Cellular Component

GO:0016324  apical plasma membrane
GO:0032809  cell soma membrane
GO:0009986  cell surface
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016021  integral to membrane
GO:0005896  interleukin-6 receptor complex
GO:0016020  membrane

Molecular Function

GO:0070119  ciliary neurotrophic factor binding
GO:0004897  ciliary neurotrophic factor receptor activity
GO:0004896  cytokine receptor activity
GO:0019899  enzyme binding
GO:0019981  interleukin-6 binding
GO:0004915  interleukin-6 receptor activity
GO:0005138  interleukin-6 receptor binding
GO:0042803  protein homodimerization activity