purinergic receptor P2X, ligand-gated ion channel 4

 jump to detail

Synonym

AW555605, AI504491, P2rx4, P2X4, D5Ertd444e

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:43.20 peripheral blood:- spleen:- thymus:- bone marrow:25.60 adipose:- bone:- skin:-
GeneChip cerebrum:6.90 cerebellum:7.49 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.12 spine:7.39 retina:6.78 eye:7.81 artery/aorta:- vein:7.43 lymphnode:9.16 peripheral blood:- spleen:8.93 thymus:- bone marrow:7.75 adipose:8.16 bone:7.75 skin:7.71
CAGE cerebrum:2.61 cerebellum:- brain stem:2.75 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.00 retina:- eye:- artery/aorta:3.34 vein:- lymphnode:4.15 peripheral blood:- spleen:3.43 thymus:3.08 bone marrow:- adipose:- bone:3.73 skin:3.40
RNA-seq cerebrum:3.58 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:8.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:8.84 placenta:9.28 prostate:10.24 ovary:8.17 testis:6.66 heart:7.58 muscle:7.15 esophagus:- stomach:8.84 intestine:9.60 colon:- liver/hepato:9.29 lung:9.10 bladder:8.11 kidney:8.59 pituitary:7.88 thyroid/parathyroid:- adrenal gland:8.26 pancreas:8.98 breast:8.31 salivary:10.97
CAGE uterus:3.56 placenta:4.01 prostate:4.59 ovary:3.42 testis:1.34 heart:- muscle:- esophagus:- stomach:4.08 intestine:3.52 colon:3.98     liver/hepato:4.21    lung:4.09 bladder:3.47 kidney:- pituitary:3.17 thyroid/parathyroid:- adrenal gland:3.56 pancreas:4.15 breast:3.66 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.47 esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.86        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_011026
Gene ID 18438
Unigene ID Mm.463383
Probe set ID 1425525_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000029470

Orthologous Gene

Human[1]  NM_002560
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001429  P2X purinoreceptor
IPR003044  P2X1 purinoceptor
IPR003047  P2X4 purinoceptor

Link to Pubmed  (Pubmed ID)

9931497
10349636
10725249
10922068
11042159
11076861
11217851
12077552
12466851
12477932
14610273
15081800
15670583
15782199
16141072
16141073
16327800
16449800
16602821
16943557
16985003
17560948
17675190
17785580
17825926
17873021
17934511
17940064
17990272
18240312
18407780
18641271
18657557
18971468
19036987
19076210
19201994
19283779
19304656
19403602
19442872
19515262
20231374
20562826
21267068
21441897
21482824
21677750
21749490
21798232
21865744
22318986
22349510
22378878
22393055
22405772
22451435
22685336
22915101
23292683
23428419
23525041
23567069
23604007
23828736
24123515
24409095

Gene Ontology  (GO ID)

Biological Process

GO:0006816  calcium ion transport
GO:0006812  cation transport
GO:0034220  ion transmembrane transport
GO:0006811  ion transport
GO:0051899  membrane depolarization
GO:0010614  negative regulation of cardiac muscle hypertrophy
GO:0006809  nitric oxide biosynthetic process
GO:0010524  positive regulation of calcium ion transport into cytosol
GO:0050850  positive regulation of calcium-mediated signaling
GO:0051260  protein homooligomerization
GO:0019228  regulation of action potential in neuron
GO:0008217  regulation of blood pressure
GO:0055117  regulation of cardiac muscle contraction
GO:0060079  regulation of excitatory postsynaptic membrane potential
GO:0002028  regulation of sodium ion transport
GO:0055119  relaxation of cardiac muscle
GO:0033198  response to ATP
GO:0034405  response to fluid shear stress
GO:0019233  sensory perception of pain
GO:0007165  signal transduction
GO:0006810  transport
GO:0042311  vasodilation

Cellular Component

GO:0045177  apical part of cell
GO:0030424  axon
GO:0030054  cell junction
GO:0043025  cell soma
GO:0030425  dendrite
GO:0043197  dendritic spine
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045202  synapse
GO:0043195  terminal button

Molecular Function

GO:0005524  ATP binding
GO:0004931  ATP-gated cation channel activity
GO:0045296  cadherin binding
GO:0005507  copper ion binding
GO:0008144  drug binding
GO:0005216  ion channel activity
GO:0001614  purinergic nucleotide receptor activity
GO:0005102  receptor binding
GO:0008270  zinc ion binding