pyruvate dehydrogenase kinase, isoenzyme 2

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Synonym

pyruvate dehydrogenase kinase, isoenzyme 2, Pdk2, Pyruvate dehydrogenase kinase isoform 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:8.01 cerebellum:9.18 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.19 spine:8.94 retina:5.85 eye:6.13 artery/aorta:- vein:5.90 lymphnode:6.17 peripheral blood:- spleen:5.49 thymus:- bone marrow:5.83 adipose:9.67 bone:6.11 skin:7.15
CAGE cerebrum:5.47 cerebellum:- brain stem:5.16 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:5.42 retina:- eye:- artery/aorta:6.58 vein:- lymphnode:3.38 peripheral blood:- spleen:2.70 thymus:3.17 bone marrow:- adipose:- bone:5.10 skin:5.12
RNA-seq cerebrum:29.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:7.24 placenta:6.30 prostate:9.35 ovary:7.43 testis:9.76 heart:10.65 muscle:11.22 esophagus:- stomach:8.16 intestine:8.01 colon:- liver/hepato:8.85 lung:7.36 bladder:7.45 kidney:9.96 pituitary:7.22 thyroid/parathyroid:- adrenal gland:7.79 pancreas:8.31 breast:9.03 salivary:9.08
CAGE uterus:3.91 placenta:2.83 prostate:4.71 ovary:4.34 testis:5.95 heart:- muscle:- esophagus:- stomach:5.24 intestine:4.83 colon:5.08     liver/hepato:5.28    lung:4.22 bladder:4.67 kidney:- pituitary:4.18 thyroid/parathyroid:- adrenal gland:4.31 pancreas:4.89 breast:4.67 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:65.02 esophagus:- stomach:- intestine:- colon:-     liver/hepato:15.17        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_133667
Gene ID 18604
Unigene ID Mm.297680
Probe set ID 1448825_at  [Mouse430_2]
Ensembl ID ENSMUSG00000038967

Orthologous Gene

Human[2]  NM_001199898, NM_001199899, NM_001199900, NM_002611
Rat[2]  NM_030872, NM_001199899, NM_001199900, NM_002611

Chromosomal Region

-

Gene Family (Interpro ID)

IPR003594  ATPase-like, ATP-binding domain

Link to Pubmed  (Pubmed ID)

8889548
9806826
10349636
11042159
11076861
11217851
12466851
12477932
14651853
15102471
15782199
16141072
16141073
16319116
18614015
19147752
21190881
21267068
21411764
22123926
22360721
22983710
23290136
23940800
24356970

Gene Ontology  (GO ID)

Biological Process

GO:0005975  carbohydrate metabolic process
GO:0031670  cellular response to nutrient
GO:0034614  cellular response to reactive oxygen species
GO:0042593  glucose homeostasis
GO:0006006  glucose metabolic process
GO:0008286  insulin receptor signaling pathway
GO:0018105  peptidyl-serine phosphorylation
GO:0016310  phosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0010510  regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565  regulation of cellular ketone metabolic process
GO:0006111  regulation of gluconeogenesis
GO:0010906  regulation of glucose metabolic process
GO:0006885  regulation of pH

Cellular Component

GO:0005737  cytoplasm
GO:0005967  mitochondrial pyruvate dehydrogenase complex
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0045254  pyruvate dehydrogenase complex

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0004674  protein serine/threonine kinase activity
GO:0004740  pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0016740  transferase activity