protein kinase C, iota

Synonym

Pkcl, Pkci, KIAA4165, Atypical protein kinase C-lambda/iota, nPKC-iota, Protein kinase C iota type, aPKC-lambda/iota, aPKClambda, mKIAA4165, Prkci, protein kinase C, iota, Prkcl, 2310021H13Rik, AI427505

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:67.70

cerebellum:36.80

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:19.10

spine:141.90

retina:96.40

eye:129.20

artery/aorta:84.40

vein:-

lymphnode:10.80

peripheral blood:115

spleen:39.50

thymus:98.80

bone marrow:12.80

adipose:-

bone:37.60

skin:79.20

GeneChip

cerebrum:7.81

cerebellum:7.88

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:7.30

spine:7.69

retina:6.66

eye:7.07

artery/aorta:-

vein:8.34

lymphnode:7.04

peripheral blood:-

spleen:7.09

thymus:-

bone marrow:6.79

adipose:7.76

bone:6.77

skin:7.81

CAGE

cerebrum:3.17

cerebellum:-

brain stem:2.96

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:3.10

retina:-

eye:-

artery/aorta:3.34

vein:-

lymphnode:2.77

peripheral blood:-

spleen:2.34

thymus:3.01

bone marrow:-

adipose:-

bone:2.45

skin:4.56

RNA-seq

cerebrum:4.73

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:138.10

prostate:30.90

ovary:46

testis:118.20

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:105.70

liver/hepato:-

lung:160.70

bladder:66.20

kidney:16.10

pituitary:51.70

thyroid/parathyroid:224.90

adrenal gland:424.40

pancreas:122

breast:137.10

salivary:-

GeneChip

uterus:7.90

placenta:9.86

prostate:7.83

ovary:7.73

testis:7.37

heart:6.89

muscle:6.71

esophagus:-

stomach:8.23

intestine:8.07

colon:-

liver/hepato:7.25

lung:8.52

bladder:8.44

kidney:7.59

pituitary:7.40

thyroid/parathyroid:-

adrenal gland:7.26

pancreas:7.21

breast:7.96

salivary:7.18

CAGE

uterus:3.60

placenta:4.32

prostate:4.16

ovary:3.72

testis:2.98

heart:-

muscle:-

esophagus:-

stomach:3.57

intestine:3.67

colon:3.36

liver/hepato:3.22

lung:4.54

bladder:4.31

kidney:-

pituitary:2.81

thyroid/parathyroid:-

adrenal gland:3.32

pancreas:2.97

breast:4.23

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.81

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:3.36

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_008857
Gene ID	18759
Unigene ID	Mm.291554
Probe set ID	1448695_at [Mouse430_2]
Ensembl ID	ENSMUSG00000037643

Orthologous Gene

Human[3]	NM_002740
Rat[1]	NM_032059

Chromosomal Region

Gene Family (Interpro ID)

IPR000961	AGC-kinase, C-terminal
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0007015	actin filament organization
GO:0016477	cell migration
GO:0045216	cell-cell junction organization
GO:0034613	cellular protein localization
GO:0032869	cellular response to insulin stimulus
GO:0035089	establishment of apical/basal cell polarity
GO:0042462	eye photoreceptor cell development
GO:0048194	Golgi vesicle budding
GO:0007275	multicellular organismal development
GO:0034351	negative regulation of glial cell apoptosis
GO:0043524	negative regulation of neuron apoptosis
GO:0016310	phosphorylation
GO:0090004	positive regulation of establishment of protein localization in plasma membrane
GO:0060252	positive regulation of glial cell proliferation
GO:0046326	positive regulation of glucose import
GO:0010976	positive regulation of neuron projection development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0006468	protein amino acid phosphorylation
GO:0070555	response to interleukin-1
GO:0043434	response to peptide hormone stimulus

Cellular Component

GO:0045177	apical part of cell
GO:0016324	apical plasma membrane
GO:0031252	cell leading edge
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005768	endosome
GO:0016020	membrane
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0043220	Schmidt-Lanterman cleft
GO:0005923	tight junction

Molecular Function

GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding
GO:0000166	nucleotide binding
GO:0005543	phospholipid binding
GO:0019904	protein domain specific binding
GO:0004672	protein kinase activity
GO:0004697	protein kinase C activity
GO:0004674	protein serine/threonine kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0008270	zinc ion binding

protein kinase C, iota

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function