protein kinase D1

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Synonym

Prkcm, Prkd1, Pkd, nPKC-mu, Protein kinase C mu type, PKD, nPKC-D1, protein kinase C, mu, Serine/threonine-protein kinase D1, PKD1, Pkcm, Protein kinase D

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:6.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:19.10 spine:- retina:- eye:53.20 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:9.90 bone marrow:- adipose:- bone:25 skin:-
GeneChip cerebrum:6.26 cerebellum:5.61 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.62 spine:6.17 retina:7.27 eye:6.50 artery/aorta:- vein:5.65 lymphnode:5.35 peripheral blood:- spleen:5.66 thymus:- bone marrow:4.54 adipose:7.74 bone:4.61 skin:5.03
CAGE cerebrum:1.53 cerebellum:- brain stem:1.34 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.51 retina:- eye:- artery/aorta:2.24 vein:- lymphnode:0.42 peripheral blood:- spleen:0.71 thymus:0.49 bone marrow:- adipose:- bone:0 skin:1.42
RNA-seq cerebrum:1.51 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:130.90 placenta:- prostate:30.90 ovary:160.90 testis:29.60 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:40.20    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:9.40 breast:29.40 salivary:-
GeneChip uterus:5.75 placenta:4.97 prostate:5.24 ovary:6.56 testis:5.72 heart:6.18 muscle:5.59 esophagus:- stomach:5.55 intestine:5.02 colon:- liver/hepato:5.14 lung:7.53 bladder:5.34 kidney:6.08 pituitary:5.75 thyroid/parathyroid:- adrenal gland:6.93 pancreas:5.77 breast:6.33 salivary:5.44
CAGE uterus:1.46 placenta:0.58 prostate:0.74 ovary:2.07 testis:1.60 heart:- muscle:- esophagus:- stomach:1.07 intestine:0.72 colon:0.70     liver/hepato:0    lung:2.57 bladder:1.58 kidney:- pituitary:1.22 thyroid/parathyroid:- adrenal gland:2.37 pancreas:1.61 breast:0.90 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.89        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008858
Gene ID 18760
Unigene ID Mm.133719
Probe set ID 1422673_at  [Mouse430_2]
Ensembl ID ENSMUSG00000002688

Orthologous Gene

Human[1]  NM_002742
Rat[1]  NM_002742

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

2266135
7836415
8078925
9854032
10473617
10882525
11239398
12466851
14573624
14613966
15190080
15192707
15623513
16098040
16111639
16377259
16380231
16503160
16537572
16713972
17322173
17485491
17707375
17964599
18164589
18179777
18239146
18287012
18378694
18641342
18753385
19029091
19116445
19135240
19145237
19211839
19414785
19804826
20018870
20142359
20177824
20434520
20463010
20660060
20819079
21051537
21078968
21132013
21148796
21267068
21345437
21424113
21677750
22158620
22276203
22595992
22636676
22820510
22928050
22975325
23129748
23970782
23970783
24213370
24643961
24647541

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0030154  cell differentiation
GO:0034599  cellular response to oxidative stress
GO:0007030  Golgi organization
GO:0048193  Golgi vesicle transport
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0060548  negative regulation of cell death
GO:0007399  nervous system development
GO:0018105  peptidyl-serine phosphorylation
GO:0016310  phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0043536  positive regulation of blood vessel endothelial cell migration
GO:0032793  positive regulation of CREB transcription factor activity
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0010976  positive regulation of neuron projection development
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045669  positive regulation of osteoblast differentiation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0010837  regulation of keratinocyte proliferation
GO:0048010  vascular endothelial growth factor receptor signaling pathway

Cellular Component

GO:0005938  cell cortex
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005794  Golgi apparatus
GO:0005622  intracellular
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0005802  trans-Golgi network

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0016301  kinase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0005543  phospholipid binding
GO:0004672  protein kinase activity
GO:0004697  protein kinase C activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups