phospholipase A2, group IVA (cytosolic, calcium-dependent)

Synonym

Cpla2, Cytosolic phospholipase A2, cPLA2-alpha, Pla2g4, Phospholipase A2 group IVA, Type IV PLA2, cytosolic phospholipase A2, cytosolic PLA2, cPLA2, Pla2g4a

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:41.70

cerebellum:-

brain stem:63.60

corpus callosum/glia:-

pineal gland:515.60

peripheral nerve:95.50

spine:-

retina:-

eye:38

artery/aorta:168.80

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:9.90

bone marrow:-

adipose:-

bone:212.90

skin:63.30

GeneChip

cerebrum:4.71

cerebellum:4.50

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:4.78

spine:6.66

retina:5.22

eye:7.96

artery/aorta:-

vein:8.83

lymphnode:7.55

peripheral blood:-

spleen:6.78

thymus:-

bone marrow:8.19

adipose:6.10

bone:8.23

skin:8.27

CAGE

cerebrum:1.97

cerebellum:-

brain stem:2.61

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:3.25

retina:-

eye:-

artery/aorta:3.35

vein:-

lymphnode:3.80

peripheral blood:-

spleen:3.15

thymus:2.61

bone marrow:-

adipose:-

bone:3.46

skin:3.49

RNA-seq

cerebrum:1.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:87.20

placenta:-

prostate:-

ovary:-

testis:66.50

heart:18.60

muscle:-

esophagus:-

stomach:-

intestine:-

colon:17.60

liver/hepato:-

lung:150.60

bladder:66.20

kidney:16.10

pituitary:129.20

thyroid/parathyroid:-

adrenal gland:-

pancreas:37.50

breast:104.50

salivary:54

GeneChip

uterus:9.31

placenta:7.12

prostate:8.31

ovary:8.19

testis:4.50

heart:6.18

muscle:5.09

esophagus:-

stomach:8.39

intestine:8.29

colon:-

liver/hepato:4.73

lung:7.05

bladder:9.42

kidney:6.04

pituitary:4.33

thyroid/parathyroid:-

adrenal gland:6.12

pancreas:4.14

breast:6.49

salivary:5.16

CAGE

uterus:4.58

placenta:2.91

prostate:2.51

ovary:3.79

testis:0.75

heart:-

muscle:-

esophagus:-

stomach:4.01

intestine:2.54

colon:3.15

liver/hepato:2.02

lung:3.32

bladder:4.44

kidney:-

pituitary:1.40

thyroid/parathyroid:-

adrenal gland:2.65

pancreas:1.61

breast:3.35

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.24

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:1.54

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_008869
Gene ID	18783
Unigene ID	Mm.41860
Probe set ID	1448558_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000056220

Orthologous Gene

Human[1]	NM_024420
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
IPR000008	C2 calcium-dependent membrane targeting
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR018029	C2 membrane targeting protein
IPR002642	Lysophospholipase, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0019369	arachidonic acid metabolic process
GO:0050482	arachidonic acid secretion
GO:0071236	cellular response to antibiotic
GO:0046697	decidualization
GO:0046456	icosanoid biosynthetic process
GO:0016042	lipid catabolic process
GO:0006629	lipid metabolic process
GO:0008152	metabolic process
GO:0001542	ovulation from ovarian follicle
GO:0009395	phospholipid catabolic process
GO:0043065	positive regulation of apoptosis
GO:0008284	positive regulation of cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0031394	positive regulation of prostaglandin biosynthetic process
GO:0031340	positive regulation of vesicle fusion
GO:0042127	regulation of cell proliferation
GO:0051592	response to calcium ion
GO:0010033	response to organic substance
GO:0043129	surfactant homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0031410	cytoplasmic vesicle
GO:0005829	cytosol
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0042588	zymogen granule

Molecular Function

GO:0005509	calcium ion binding
GO:0047498	calcium-dependent phospholipase A2 activity
GO:0005544	calcium-dependent phospholipid binding
GO:0016787	hydrolase activity
GO:0004622	lysophospholipase activity
GO:0046872	metal ion binding
GO:0004623	phospholipase A2 activity
GO:0004620	phospholipase activity

phospholipase A2, group IVA (cytosolic, calcium-dependent)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function