protein tyrosine phosphatase, receptor type, J

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Synonym

Ptprj, Scc-1, AI450271, Ptpb2, Protein-tyrosine phosphatase receptor type J, Susceptibility to colon cancer 1, Byp, Protein-tyrosine phosphatase eta, DEP-1, Scc1, R-PTP-eta, CD148, protein tyrosine phosphatase, receptor type, J, BET, HPTP beta-like tyrosine phosphatase, PTPbeta2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:60.80 cerebellum:92.10 brain stem:95.30 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:47.30 retina:- eye:15.20 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:26.30 thymus:9.90 bone marrow:153.90 adipose:- bone:25 skin:31.70
GeneChip cerebrum:4.14 cerebellum:4.51 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:3.65 spine:4.02 retina:4.68 eye:4.53 artery/aorta:- vein:4.01 lymphnode:5.12 peripheral blood:- spleen:5.81 thymus:- bone marrow:4.88 adipose:3.93 bone:4.89 skin:4.88
CAGE cerebrum:3.27 cerebellum:- brain stem:2.84 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.60 retina:- eye:- artery/aorta:3.15 vein:- lymphnode:4.25 peripheral blood:- spleen:4.03 thymus:2.22 bone marrow:- adipose:- bone:4.18 skin:2.82
RNA-seq cerebrum:1.73 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:11.50 testis:7.40 heart:- muscle:- esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:-        lung:-    bladder:264.70 kidney:8.10 pituitary:12.90 thyroid/parathyroid:- adrenal gland:424.40 pancreas:- breast:45.70 salivary:-
GeneChip uterus:4.20 placenta:3.93 prostate:4.44 ovary:4.06 testis:4.81 heart:4.09 muscle:3.97 esophagus:- stomach:4.08 intestine:4.49 colon:- liver/hepato:4.17 lung:4.13 bladder:3.96 kidney:4.16 pituitary:4.33 thyroid/parathyroid:- adrenal gland:4.10 pancreas:4.51 breast:4.27 salivary:4.88
CAGE uterus:3.55 placenta:2.38 prostate:3.39 ovary:2.53 testis:4.04 heart:- muscle:- esophagus:- stomach:2.16 intestine:2.64 colon:3.24     liver/hepato:3.71    lung:3.71 bladder:2.52 kidney:- pituitary:2.89 thyroid/parathyroid:- adrenal gland:2.83 pancreas:2.75 breast:3.38 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:0.41 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.71        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001135657
Gene ID 19271
Unigene ID Mm.330393
Probe set ID 1427629_at  [Mouse430_2]
Ensembl ID ENSMUSG00000025314

Orthologous Gene

Human[2]  NM_001098503, NM_002843
Rat[2]  NM_001098503, NM_002843

Chromosomal Region

2E1  [90,269,911  -  90,420,804]

Gene Family (Interpro ID)

IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR000242  Protein-tyrosine phosphatase, receptor/non-receptor type

Link to Pubmed  (Pubmed ID)

1347918
1932742
2044862
7838537
8549806
8575779
8577718
8940077
8944029
9823776
10349636
11042159
11076861
11217851
12089527
12466851
12588999
12771128
12833140
12913111
14562056
14610273
15294945
15782199
16141072
16141073
16602821
16792508
18249142
18308476
19139271
19246339
19268662
19727691
20345711
21098033
21262971
21267068
21469128
21543337
22078799
22246030
22815804
23065825
23543053
23580664

Gene Ontology  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0016311  dephosphorylation
GO:0007507  heart development
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0042059  negative regulation of epidermal growth factor receptor signaling pathway
GO:0043407  negative regulation of MAP kinase activity
GO:0010642  negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0050860  negative regulation of T cell receptor signaling pathway
GO:0043116  negative regulation of vascular permeability
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0050918  positive chemotaxis
GO:0045785  positive regulation of cell adhesion
GO:0001954  positive regulation of cell-matrix adhesion
GO:0051894  positive regulation of focal adhesion formation
GO:0010759  positive regulation of macrophage chemotaxis
GO:0010572  positive regulation of platelet activation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0006470  protein amino acid dephosphorylation
GO:0030155  regulation of cell adhesion
GO:0001570  vasculogenesis

Cellular Component

GO:0030054  cell junction
GO:0042995  cell projection
GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0001772  immunological synapse
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0005886  plasma membrane
GO:0032587  ruffle membrane

Molecular Function

GO:0008013  beta-catenin binding
GO:0070097  delta-catenin binding
GO:0045295  gamma-catenin binding
GO:0016787  hydrolase activity
GO:0051019  mitogen-activated protein kinase binding
GO:0016791  phosphatase activity
GO:0004721  phosphoprotein phosphatase activity
GO:0005161  platelet-derived growth factor receptor binding
GO:0019901  protein kinase binding
GO:0004725  protein tyrosine phosphatase activity