chemokine (C-C motif) ligand 5

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Synonym

MuRantes, TCP228, Small inducible cytokine A5 precursor, SISd, chemokine (C-C motif) ligand 5, SIS-delta, Ccl5, T-cell-specific RANTES protein, Scya5, CCL5, RANTES

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:76.40 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:26.30 thymus:49.40 bone marrow:89.80 adipose:- bone:- skin:-
GeneChip cerebrum:5.44 cerebellum:5.59 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.19 spine:5.70 retina:5.78 eye:6.79 artery/aorta:- vein:5.75 lymphnode:11.89 peripheral blood:- spleen:11.07 thymus:- bone marrow:7.99 adipose:7.11 bone:7.78 skin:5.74
CAGE cerebrum:0.76 cerebellum:- brain stem:1.16 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.91 retina:- eye:- artery/aorta:3.66 vein:- lymphnode:6.75 peripheral blood:- spleen:5.74 thymus:5.33 bone marrow:- adipose:- bone:4.30 skin:1.03
RNA-seq cerebrum:0.93 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:30.90 ovary:- testis:- heart:18.60 muscle:- esophagus:- stomach:- intestine:406.70 colon:-     liver/hepato:-        lung:10    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:28.10 breast:22.90 salivary:108
GeneChip uterus:7.22 placenta:6.30 prostate:6.38 ovary:6.10 testis:6.43 heart:6.18 muscle:6.23 esophagus:- stomach:6.48 intestine:8.04 colon:- liver/hepato:6.37 lung:8.38 bladder:6.43 kidney:6.10 pituitary:5.94 thyroid/parathyroid:- adrenal gland:6.03 pancreas:6.79 breast:8.78 salivary:7.39
CAGE uterus:3.18 placenta:1.40 prostate:2.70 ovary:2.59 testis:0.75 heart:- muscle:- esophagus:- stomach:3.54 intestine:4.12 colon:5.79     liver/hepato:2.48    lung:5.79 bladder:2.80 kidney:- pituitary:1.96 thyroid/parathyroid:- adrenal gland:4.75 pancreas:3.04 breast:4.14 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.94 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.56        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_013653
Gene ID 20304
Unigene ID Mm.284248
Probe set ID 1418126_at  [Mouse430_2]
Ensembl ID ENSMUSG00000035042

Orthologous Gene

Human[2]  NM_002985
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001811  Small chemokine, interleukin-8-like

Link to Pubmed  (Pubmed ID)

1375672
1376260
2456327
7507961
7513046
7542490
7594543
7594550
8981365
9311871
9365123
9730682
10235110
10349636
10438970
10594742
10790402
10995569
11000125
11042159
11076861
11217851
11466387
11744622
11801530
11818130
11890717
11893739
11911480
11972057
11987989
12077225
12080938
12093895
12112372
12126650
12234959
12466851
12477932
12850812
12928419
14687724
14761932
15034013
15240757
15271961
15381731
15489334
15546955
15557190
15718270
15748167
15860458
15890969
15905535
16141072
16141073
16208318
16455992
16602821
16707500
16807117
16849492
16873271
16940143
16982880
16983723
17220320
17244892
17641009
17641205
17893273
17978871
18287559
18388327
18624307
18635850
18700040
18815890
18986535
19006696
19121387
19236348
19421418
19427874
19524301
19665464
19779041
19853894
19923453
20038813
20046229
20371596
20400704
20442771
20573836
20720435
20864798
20886281
20978355
21074454
21148126
21267068
21293018
21302497
21335555
21454528
21565393
21680945
21715689
21814510
22088941
22156592
22178100
22205974
22214846
22289892
22297845
22385043
22425022
22447977
22494696
22494919
22679098
22797700
23112334
23132945
23266888
23288157
23460747
23498790
23553711
23620790
23696660
23722213
23810773
23900076
23918941
23935096
24464131
24711619

Gene Ontology  (GO ID)

Biological Process

GO:0031584  activation of phospholipase D activity
GO:0006816  calcium ion transport
GO:0007267  cell-cell signaling
GO:0006874  cellular calcium ion homeostasis
GO:0043623  cellular protein complex assembly
GO:0071407  cellular response to organic cyclic substance
GO:0006935  chemotaxis
GO:0048245  eosinophil chemotaxis
GO:0006887  exocytosis
GO:0006955  immune response
GO:0006954  inflammatory response
GO:0007159  leukocyte adhesion
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0048247  lymphocyte chemotaxis
GO:0000165  MAPKKK cascade
GO:0043922  negative regulation by host of viral transcription
GO:0060548  negative regulation of cell death
GO:0070100  negative regulation of chemokine-mediated signaling pathway
GO:0045744  negative regulation of G-protein coupled receptor protein signaling pathway
GO:0070233  negative regulation of T cell apoptosis
GO:0045071  negative regulation of viral genome replication
GO:0042119  neutrophil activation
GO:0050918  positive chemotaxis
GO:0045766  positive regulation of angiogenesis
GO:0051928  positive regulation of calcium ion transport
GO:0045785  positive regulation of cell adhesion
GO:0030335  positive regulation of cell migration
GO:0033634  positive regulation of cell-cell adhesion mediated by integrin
GO:0031328  positive regulation of cellular biosynthetic process
GO:0002230  positive regulation of defense response to virus by host
GO:0031622  positive regulation of fever
GO:0010628  positive regulation of gene expression
GO:0034112  positive regulation of homotypic cell-cell adhesion
GO:0010759  positive regulation of macrophage chemotaxis
GO:0060754  positive regulation of mast cell chemotaxis
GO:0090026  positive regulation of monocyte chemotaxis
GO:0045666  positive regulation of neuron differentiation
GO:0045672  positive regulation of osteoclast differentiation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0042327  positive regulation of phosphorylation
GO:0014911  positive regulation of smooth muscle cell migration
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0070234  positive regulation of T cell apoptosis
GO:0010820  positive regulation of T cell chemotaxis
GO:0042102  positive regulation of T cell proliferation
GO:0042531  positive regulation of tyrosine phosphorylation of STAT protein
GO:0006468  protein amino acid phosphorylation
GO:0043491  protein kinase B signaling cascade
GO:0051262  protein tetramerization
GO:0031269  pseudopodium assembly
GO:0050863  regulation of T cell activation
GO:0034097  response to cytokine stimulus
GO:0034341  response to interferon-gamma
GO:0009636  response to toxin
GO:0034612  response to tumor necrosis factor

Cellular Component

GO:0005623  cell
GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005622  intracellular

Molecular Function

GO:0031726  CCR1 chemokine receptor binding
GO:0031730  CCR5 chemokine receptor binding
GO:0042056  chemoattractant activity
GO:0008009  chemokine activity
GO:0046817  chemokine receptor antagonist activity
GO:0042379  chemokine receptor binding
GO:0005125  cytokine activity
GO:0008201  heparin binding
GO:0004435  phosphoinositide phospholipase C activity
GO:0016004  phospholipase activator activity
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0043621  protein self-association
GO:0030298  receptor signaling protein tyrosine kinase activator activity