topoisomerase (DNA) II alpha

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Synonym

DNA topoisomerase 2-alpha, topoisomerase (DNA) II alpha, Top2a, DNA topoisomerase II, alpha isozyme, Top-2, DNA Topoisomerase II alpha, Top2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:13.20 thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.65 cerebellum:4.31 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.89 spine:4.75 retina:4.57 eye:6.18 artery/aorta:- vein:9.47 lymphnode:9.46 peripheral blood:- spleen:9.33 thymus:- bone marrow:12.25 adipose:5.89 bone:11.95 skin:8.80
CAGE cerebrum:0.43 cerebellum:- brain stem:0.31 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.66 retina:- eye:- artery/aorta:2.03 vein:- lymphnode:4.34 peripheral blood:- spleen:5.34 thymus:5.73 bone marrow:- adipose:- bone:5.52 skin:3.64
RNA-seq cerebrum:0.73 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:10    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:8.96 placenta:5.94 prostate:6.97 ovary:8.98 testis:9.96 heart:5.77 muscle:5.56 esophagus:- stomach:8.72 intestine:10.14 colon:- liver/hepato:5.05 lung:6.35 bladder:6.15 kidney:5.07 pituitary:6.17 thyroid/parathyroid:- adrenal gland:5.74 pancreas:6.28 breast:7.37 salivary:6.10
CAGE uterus:3.49 placenta:2.71 prostate:2.09 ovary:3.83 testis:4.70 heart:- muscle:- esophagus:- stomach:2.79 intestine:4.67 colon:4.32     liver/hepato:0.64    lung:2.85 bladder:1.62 kidney:- pituitary:1.22 thyroid/parathyroid:- adrenal gland:1.55 pancreas:1.30 breast:3.63 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.04 esophagus:- stomach:- intestine:- colon:-     liver/hepato:0        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_011623
Gene ID 21973
Unigene ID Mm.423714
Probe set ID 1454694_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020914

Orthologous Gene

Human [0]  
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1331984
1380833
1683482
2555055
7671812
7842491
7937150
8241259
8261398
8389625
8884812
9020022
9040785
9094096
9224616
9714832
10207078
10349636
10922068
10942766
11042159
11076861
11217851
11835579
11835580
11940566
12149265
12439594
12466851
12477932
12520002
12859955
12904583
14610273
14681479
16091739
16107646
16141072
16141073
16611985
17011187
17362930
17578914
17998154
18032420
18394993
18451150
18799693
19521500
19936747
20362542
21327095
21589869
21677750
22111588
22308494
23086144
23466610
23505375
23698369
24029230
24048577
24072229
24154525

Gene Ontology  (GO ID)

Biological Process

GO:0030263  apoptotic chromosome condensation
GO:0006200  ATP catabolic process
GO:0030261  chromosome condensation
GO:0007059  chromosome segregation
GO:0006266  DNA ligation
GO:0006259  DNA metabolic process
GO:0006265  DNA topological change
GO:0006261  DNA-dependent DNA replication
GO:0040016  embryonic cleavage
GO:0006312  mitotic recombination
GO:0043065  positive regulation of apoptosis
GO:0045870  positive regulation of retroviral genome replication
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045070  positive regulation of viral genome replication
GO:0000712  resolution of meiotic recombination intermediates
GO:0006974  response to DNA damage stimulus
GO:0000819  sister chromatid segregation

Cellular Component

GO:0005814  centriole
GO:0000793  condensed chromosome
GO:0009330  DNA topoisomerase complex (ATP-hydrolyzing)
GO:0000228  nuclear chromosome
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0043234  protein complex
GO:0000795  synaptonemal complex

Molecular Function

GO:0005524  ATP binding
GO:0003682  chromatin binding
GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0003918  DNA topoisomerase (ATP-hydrolyzing) activity
GO:0003916  DNA topoisomerase activity
GO:0008094  DNA-dependent ATPase activity
GO:0008144  drug binding
GO:0019899  enzyme binding
GO:0042826  histone deacetylase binding
GO:0016853  isomerase activity
GO:0000287  magnesium ion binding
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0008022  protein C-terminus binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0005080  protein kinase C binding
GO:0043565  sequence-specific DNA binding
GO:0043566  structure-specific DNA binding
GO:0043130  ubiquitin binding