alanyl-tRNA synthetase

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Synonym

AlaRS, Alanyl-tRNA synthetase, cytoplasmic, alanyl-tRNA synthetase, sti, Aars, MGC37368, AI316495, C76919, Alanine--tRNA ligase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:9.57 cerebellum:10.29 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.92 spine:10.24 retina:9.01 eye:7.68 artery/aorta:- vein:8.04 lymphnode:8.92 peripheral blood:- spleen:8.64 thymus:- bone marrow:9.67 adipose:9.07 bone:9.05 skin:7.80
CAGE cerebrum:4.43 cerebellum:- brain stem:4.73 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.86 retina:- eye:- artery/aorta:3.78 vein:- lymphnode:3.53 peripheral blood:- spleen:4.58 thymus:3.17 bone marrow:- adipose:- bone:3.92 skin:3.74
RNA-seq cerebrum:28.06 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:9.04 placenta:9.03 prostate:8.58 ovary:9.43 testis:10.03 heart:8.33 muscle:9.80 esophagus:- stomach:9.31 intestine:9.15 colon:- liver/hepato:10.79 lung:8.95 bladder:8.75 kidney:9.46 pituitary:9.17 thyroid/parathyroid:- adrenal gland:9.81 pancreas:9.94 breast:8.98 salivary:9.82
CAGE uterus:3.54 placenta:4.32 prostate:4.31 ovary:3.94 testis:4.98 heart:- muscle:- esophagus:- stomach:3.85 intestine:3.80 colon:3.53     liver/hepato:5.03    lung:3.59 bladder:3.44 kidney:- pituitary:3.91 thyroid/parathyroid:- adrenal gland:4.26 pancreas:4.32 breast:4.06 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:11.46 esophagus:- stomach:- intestine:- colon:-     liver/hepato:26.50        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_146217
Gene ID 234734
Unigene ID -
Probe set ID 1423685_at  [Mouse430_2]
Ensembl ID ENSMUSG00000031960

Orthologous Gene

Human[1]  NM_001605
Rat[1]  NM_001100517

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10349636
10725249
10922068
11042159
11076861
11217851
12466851
12477932
12502730
12520002
12904583
14610273
14681479
15489334
15782199
16141072
16141073
16469773
16906134
17967808
18799693
19690063
20010690
21115117
21267068
21285375
21645134
23055941
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0006419  alanyl-tRNA aminoacylation
GO:0034620  cellular response to unfolded protein
GO:0021680  cerebellar Purkinje cell layer development
GO:0030968  endoplasmic reticulum unfolded protein response
GO:0001942  hair follicle development
GO:0043524  negative regulation of neuron apoptosis
GO:0050905  neuromuscular process
GO:0050885  neuromuscular process controlling balance
GO:0006457  protein folding
GO:0006450  regulation of translational fidelity
GO:0043200  response to amino acid stimulus
GO:0043588  skin development
GO:0006412  translation
GO:0043039  tRNA aminoacylation
GO:0006400  tRNA modification

Cellular Component

GO:0005737  cytoplasm

Molecular Function

GO:0004813  alanine-tRNA ligase activity
GO:0016597  amino acid binding
GO:0004812  aminoacyl-tRNA ligase activity
GO:0005524  ATP binding
GO:0016874  ligase activity
GO:0016876  ligase activity, forming aminoacyl-tRNA and related compounds
GO:0046872  metal ion binding
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0003723  RNA binding
GO:0000049  tRNA binding