beta-site APP cleaving enzyme 1

Synonym

Asp 2, ASP2, Beta-site APP cleaving enzyme 1, Bace1, beta-site APP cleaving enzyme 1, C76936, Memapsin-2, Membrane-associated aspartic protease 2, APP beta-secretase, Bace, Beta-secretase 1 precursor, Aspartyl protease 2

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:114.70

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:8.52

cerebellum:8.54

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:9.19

spine:9.18

retina:7.99

eye:7.41

artery/aorta:-

vein:8.38

lymphnode:6.79

peripheral blood:-

spleen:6.46

thymus:-

bone marrow:6.76

adipose:7.30

bone:7.02

skin:6.91

CAGE

cerebrum:3.84

cerebellum:-

brain stem:3.99

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:4.20

retina:-

eye:-

artery/aorta:3.22

vein:-

lymphnode:1.90

peripheral blood:-

spleen:1.99

thymus:1.85

bone marrow:-

adipose:-

bone:2.97

skin:3.25

RNA-seq

cerebrum:5.59

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:7.78

placenta:7.22

prostate:7.19

ovary:8.03

testis:5.36

heart:7.91

muscle:8.73

esophagus:-

stomach:6.77

intestine:6.84

colon:-

liver/hepato:7.67

lung:7.64

bladder:8.20

kidney:7.47

pituitary:7.72

thyroid/parathyroid:-

adrenal gland:7.99

pancreas:7.15

breast:7.67

salivary:7.27

CAGE

uterus:3.20

placenta:3.09

prostate:2.56

ovary:3.42

testis:0.99

heart:-

muscle:-

esophagus:-

stomach:1.91

intestine:2.06

colon:1.89

liver/hepato:2.80

lung:2.69

bladder:3.58

kidney:-

pituitary:3.43

thyroid/parathyroid:-

adrenal gland:3.27

pancreas:3.45

breast:3.08

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:2.50

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:2.56

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_001145947
Gene ID	23821
Unigene ID	Mm.240447
Probe set ID	1421824_at [Mouse430_2]
Ensembl ID	ENSMUSG00000032086

Orthologous Gene

Human[4]	NM_001207048, NM_001207049, NM_012104, NM_138971, NM_138972, NM_138973
Rat[1]	NM_019204, NM_001207049, NM_012104, NM_138971, NM_138972, NM_138973

Chromosomal Region

9A5.2 [45,646,663 - 45,672,482]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001461	Peptidase A1
IPR009120	Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1
IPR009119	Peptidase A1, beta-site APP cleaving enzyme, BACE
IPR021109	Peptidase aspartic
IPR009007	Peptidase aspartic, catalytic

Gene Ontology (GO ID)

Biological Process

GO:0050435	beta-amyloid metabolic process
GO:0006508	proteolysis

Cellular Component

GO:0030424	axon
GO:0031410	cytoplasmic vesicle
GO:0005783	endoplasmic reticulum
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0016021	integral to membrane
GO:0005887	integral to plasma membrane
GO:0016020	membrane
GO:0005802	trans-Golgi network

Molecular Function

GO:0004190	aspartic-type endopeptidase activity
GO:0004175	endopeptidase activity
GO:0019899	enzyme binding
GO:0016787	hydrolase activity
GO:0008233	peptidase activity

beta-site APP cleaving enzyme 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function