SH2B adaptor protein 2

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Synonym

Aps, SH2B adaptor protein 2, SH2 and PH domain-containing adapter protein APS, Sh2b2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:15.60 cerebellum:92.10 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:141.90 retina:- eye:- artery/aorta:- vein:- lymphnode:21.60 peripheral blood:14.40 spleen:- thymus:9.90 bone marrow:- adipose:425.40 bone:- skin:15.80
GeneChip cerebrum:5.66 cerebellum:5.65 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.57 spine:6.03 retina:5.54 eye:6.06 artery/aorta:- vein:5.50 lymphnode:6.03 peripheral blood:- spleen:5.77 thymus:- bone marrow:5.82 adipose:6.66 bone:5.58 skin:5.69
CAGE cerebrum:1.09 cerebellum:- brain stem:1.18 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.91 retina:- eye:- artery/aorta:3.71 vein:- lymphnode:0.94 peripheral blood:- spleen:0.86 thymus:0.95 bone marrow:- adipose:- bone:1.30 skin:1.20
RNA-seq cerebrum:1.42 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:32.70 intestine:- colon:-     liver/hepato:36.20        lung:10    bladder:- kidney:8.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:26.10 salivary:-
GeneChip uterus:5.56 placenta:6.08 prostate:5.51 ovary:5.57 testis:6.29 heart:5.83 muscle:6.31 esophagus:- stomach:5.71 intestine:5.52 colon:- liver/hepato:5.95 lung:5.40 bladder:5.54 kidney:5.79 pituitary:5.95 thyroid/parathyroid:- adrenal gland:5.50 pancreas:6.19 breast:5.88 salivary:5.95
CAGE uterus:0.65 placenta:2.34 prostate:0.20 ovary:1.23 testis:0 heart:- muscle:- esophagus:- stomach:0 intestine:0.58 colon:0.23     liver/hepato:1.12    lung:0.17 bladder:0.68 kidney:- pituitary:0.29 thyroid/parathyroid:- adrenal gland:1.94 pancreas:0 breast:1.64 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.36 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.58        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_018825
Gene ID 23921
Unigene ID Mm.425294
Probe set ID 1453389_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000005057

Orthologous Gene

Human [0]  
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology

Link to Pubmed  (Pubmed ID)

9989826
10196204
10349636
10854852
10872802
11042159
11076861
11217851
11827956
11997497
12444928
12466851
12477932
12842890
14578283
14612394
14766215
14993264
15031295
15231829
15809095
15946664
16141072
16141073
16455776
17102568
17204555
17620296
18492766
18799693
20298671
21677750

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0050851  antigen receptor-mediated signaling pathway
GO:0001922  B-1 B cell homeostasis
GO:0050873  brown fat cell differentiation
GO:0019221  cytokine-mediated signaling pathway
GO:0042593  glucose homeostasis
GO:0008286  insulin receptor signaling pathway
GO:0046325  negative regulation of glucose import
GO:0007399  nervous system development
GO:0050776  regulation of immune response
GO:0046425  regulation of JAK-STAT cascade
GO:0019222  regulation of metabolic process
GO:0046578  regulation of Ras protein signal transduction

Cellular Component

GO:0005884  actin filament
GO:0005737  cytoplasm
GO:0016020  membrane
GO:0005886  plasma membrane
GO:0001726  ruffle
GO:0001725  stress fiber

Molecular Function

GO:0008269  JAK pathway signal transduction adaptor activity
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0005070  SH3/SH2 adaptor activity
GO:0004871  signal transducer activity
GO:0005068  transmembrane receptor protein tyrosine kinase adaptor protein activity