excision repair cross-complementing rodent repair deficiency, complementation group 4

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Synonym

DNA excision repair protein ERCC-4, DNA repair endonuclease XPF, Xpf, Ercc4, AI606920

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:24.30 cerebellum:92.10 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:236.40 retina:32.10 eye:22.80 artery/aorta:- vein:- lymphnode:21.60 peripheral blood:43.10 spleen:- thymus:59.30 bone marrow:- adipose:- bone:25 skin:23.80
GeneChip cerebrum:4.55 cerebellum:4.95 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.96 spine:4.54 retina:3.74 eye:3.68 artery/aorta:- vein:3.92 lymphnode:4.82 peripheral blood:- spleen:4.50 thymus:- bone marrow:4.57 adipose:4.47 bone:3.97 skin:4
CAGE cerebrum:3.06 cerebellum:- brain stem:2.97 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.92 retina:- eye:- artery/aorta:2.34 vein:- lymphnode:3.85 peripheral blood:- spleen:2.71 thymus:2.96 bone marrow:- adipose:- bone:2.88 skin:3.03
RNA-seq cerebrum:7.42 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:30.90 ovary:- testis:7.40 heart:55.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:60.30    bladder:- kidney:24.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:28.10 breast:32.60 salivary:108
GeneChip uterus:4.30 placenta:4.41 prostate:4.01 ovary:4.48 testis:7.16 heart:4.39 muscle:4.72 esophagus:- stomach:4.23 intestine:4.35 colon:- liver/hepato:4.20 lung:4.37 bladder:4.52 kidney:4.57 pituitary:4.35 thyroid/parathyroid:- adrenal gland:3.83 pancreas:3.96 breast:4.31 salivary:4.06
CAGE uterus:2.77 placenta:2.36 prostate:2.67 ovary:2.71 testis:4.29 heart:- muscle:- esophagus:- stomach:2.44 intestine:2.43 colon:2.39     liver/hepato:2.48    lung:2.91 bladder:2.80 kidney:- pituitary:2.63 thyroid/parathyroid:- adrenal gland:2.83 pancreas:2.83 breast:2.39 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.51 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.25        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_015769
Gene ID 50505
Unigene ID Mm.287837
Probe set ID 1432272_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000022545

Orthologous Gene

Human[1]  NM_005236
Rat[1]  NM_005236

Chromosomal Region

-

Gene Family (Interpro ID)

IPR006166  ERCC4 domain
IPR011335  Restriction endonuclease, type II-like, core

Link to Pubmed  (Pubmed ID)

10349636
10644440
11042159
11076861
11217851
11544199
12466305
12466851
12477932
12904583
14610273
14690602
14729965
15199134
15489334
16141072
16141073
16142233
16602821
16769089
18443001
18541667
18799693
19124610
21522133
21677750
22234173
22323595

Gene Ontology  (GO ID)

Biological Process

GO:0006259  DNA metabolic process
GO:0006281  DNA repair
GO:0000724  double-strand break repair via homologous recombination
GO:0000710  meiotic mismatch repair
GO:0032205  negative regulation of telomere maintenance
GO:0006289  nucleotide-excision repair
GO:0033683  nucleotide-excision repair, DNA incision
GO:0006295  nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296  nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0000712  resolution of meiotic recombination intermediates
GO:0006974  response to DNA damage stimulus
GO:0009411  response to UV
GO:0000723  telomere maintenance
GO:0010834  telomere maintenance via telomere shortening
GO:0009650  UV protection

Cellular Component

GO:0000781  chromosome, telomeric region
GO:0000784  nuclear chromosome, telomeric region
GO:0000109  nucleotide-excision repair complex
GO:0000110  nucleotide-excision repair factor 1 complex
GO:0005634  nucleus
GO:0005669  transcription factor TFIID complex

Molecular Function

GO:0003684  damaged DNA binding
GO:0003677  DNA binding
GO:0004520  endodeoxyribonuclease activity
GO:0004519  endonuclease activity
GO:0016787  hydrolase activity
GO:0004518  nuclease activity
GO:0003676  nucleic acid binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0047485  protein N-terminus binding
GO:0003697  single-stranded DNA binding
GO:0000014  single-stranded DNA specific endodeoxyribonuclease activity
GO:0043566  structure-specific DNA binding