Parkinson disease (autosomal recessive, juvenile) 2, parkin

jump to detail

Synonym

PRKN, Parkin, MGC130518, Park2, Prkn, parkin, Ubiquitin E3 ligase PRKN

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:1.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:114.70

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:25

skin:-

GeneChip

cerebrum:4.39

cerebellum:4.41

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:4.71

spine:4.50

retina:4.23

eye:4.44

artery/aorta:-

vein:4.14

lymphnode:4.18

peripheral blood:-

spleen:4.27

thymus:-

bone marrow:4.11

adipose:4.53

bone:4.19

skin:4.26

CAGE

cerebrum:2.43

cerebellum:-

brain stem:2.22

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:2.29

retina:-

eye:-

artery/aorta:2.33

vein:-

lymphnode:1.64

peripheral blood:-

spleen:1.06

thymus:1.17

bone marrow:-

adipose:-

bone:1.02

skin:2.26

RNA-seq

cerebrum:1.31

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:23

testis:14.80

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:38.80

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:4.19

placenta:4.22

prostate:4.48

ovary:4.01

testis:5.51

heart:4.81

muscle:4.64

esophagus:-

stomach:4.43

intestine:4.27

colon:-

liver/hepato:4.39

lung:4.24

bladder:4.35

kidney:4.78

pituitary:4.51

thyroid/parathyroid:-

adrenal gland:4.05

pancreas:4.68

breast:4.33

salivary:4.64

CAGE

uterus:1.69

placenta:1.15

prostate:2.43

ovary:1.92

testis:3.18

heart:-

muscle:-

esophagus:-

stomach:1.35

intestine:0.58

colon:1.19

liver/hepato:2.09

lung:2.10

bladder:2.23

kidney:-

pituitary:3.03

thyroid/parathyroid:-

adrenal gland:2.42

pancreas:2.19

breast:1.91

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.62

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:1.68

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_016694
Gene ID	50873
Unigene ID	Mm.311110
Probe set ID	1426135_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000023826

Orthologous Gene

Human[3]	NM_004562, NM_013987, NM_013988
Rat[1]	NM_020093, NM_013987, NM_013988

Chromosomal Region

Gene Family (Interpro ID)

IPR000626	Ubiquitin
IPR019956	Ubiquitin subgroup
IPR019955	Ubiquitin supergroup

Gene Ontology (GO ID)

Biological Process

GO:0008344	adult locomotory behavior
GO:0070842	aggresome assembly
GO:0006914	autophagy
GO:0008219	cell death
GO:0042417	dopamine metabolic process
GO:0051583	dopamine uptake
GO:0007612	learning
GO:0007626	locomotory behavior
GO:0000422	mitochondrion degradation
GO:0032232	negative regulation of actin filament bundle formation
GO:0060548	negative regulation of cell death
GO:0043524	negative regulation of neuron apoptosis
GO:0001933	negative regulation of protein amino acid phosphorylation
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0070997	neuron death
GO:0042415	norepinephrine metabolic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051865	protein autoubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0019538	protein metabolic process
GO:0006513	protein monoubiquitination
GO:0000209	protein polyubiquitination
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0010506	regulation of autophagy
GO:0046928	regulation of neurotransmitter secretion
GO:0050804	regulation of synaptic transmission
GO:0006986	response to unfolded protein
GO:0001964	startle response
GO:0001963	synaptic transmission, dopaminergic
GO:0035249	synaptic transmission, glutamatergic
GO:0006511	ubiquitin-dependent protein catabolic process

Cellular Component

GO:0016235	aggresome
GO:0030054	cell junction
GO:0042995	cell projection
GO:0005737	cytoplasm
GO:0031410	cytoplasmic vesicle
GO:0005829	cytosol
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0016020	membrane
GO:0045121	membrane raft
GO:0005739	mitochondrion
GO:0043005	neuron projection
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0045211	postsynaptic membrane
GO:0043234	protein complex
GO:0045202	synapse
GO:0008021	synaptic vesicle

Molecular Function

GO:0016881	acid-amino acid ligase activity
GO:0051087	chaperone binding
GO:0019900	kinase binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0030165	PDZ domain binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0004842	ubiquitin-protein ligase activity
GO:0008270	zinc ion binding

Parkinson disease (autosomal recessive, juvenile) 2, parkin

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function