cytochrome P450, family 39, subfamily a, polypeptide 1

 jump to detail

Synonym

Cytochrome P450 39A1, Oxysterol 7-alpha-hydroxylase, mCYP39A1, Cyp39a1, 24-hydroxycholesterol 7-alpha-hydroxylase, oxysterol 7-alpha-hydroxylase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:19.10 spine:- retina:- eye:22.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:13.20 thymus:- bone marrow:- adipose:- bone:- skin:39.60
GeneChip cerebrum:4.83 cerebellum:4.92 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.10 spine:6.79 retina:7.32 eye:8.41 artery/aorta:- vein:6.97 lymphnode:5.35 peripheral blood:- spleen:6.51 thymus:- bone marrow:5.52 adipose:5.92 bone:5.56 skin:7.63
CAGE cerebrum:0.62 cerebellum:- brain stem:0.75 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.83 retina:- eye:- artery/aorta:1.53 vein:- lymphnode:2.17 peripheral blood:- spleen:1.36 thymus:0.27 bone marrow:- adipose:- bone:1.30 skin:2.50
RNA-seq cerebrum:2.47 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:34.50 testis:14.80 heart:- muscle:- esophagus:- stomach:130.90 intestine:37 colon:52.90     liver/hepato:27.20        lung:-    bladder:- kidney:8.10 pituitary:51.70 thyroid/parathyroid:- adrenal gland:- pancreas:9.40 breast:49 salivary:-
GeneChip uterus:7.84 placenta:5.52 prostate:6.52 ovary:6.83 testis:4.90 heart:6.04 muscle:6.40 esophagus:- stomach:7.11 intestine:6.92 colon:- liver/hepato:8.44 lung:7.64 bladder:6.81 kidney:6.11 pituitary:5.77 thyroid/parathyroid:- adrenal gland:5.03 pancreas:10.15 breast:6.67 salivary:7.34
CAGE uterus:2.94 placenta:1.05 prostate:0.51 ovary:1.71 testis:1.80 heart:- muscle:- esophagus:- stomach:1.91 intestine:0.72 colon:2.16     liver/hepato:4.09    lung:2.84 bladder:2.14 kidney:- pituitary:1.56 thyroid/parathyroid:- adrenal gland:1.02 pancreas:4.34 breast:1.69 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.76 esophagus:- stomach:- intestine:- colon:-     liver/hepato:16.25        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_018887
Gene ID 56050
Unigene ID Mm.376968
Probe set ID 1418780_at  [Mouse430_2]
Ensembl ID ENSMUSG00000023963

Orthologous Gene

Human[1]  NM_016593
Rat[1]  NM_001106893

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001128  Cytochrome P450
IPR002401  Cytochrome P450, E-class, group I
IPR002403  Cytochrome P450, E-class, group IV

Link to Pubmed  (Pubmed ID)

8889548
10349636
10725249
10748047
10922068
11042159
11076861
11217851
12466851
12477932
12745259
14610273
14681479
16141072
16141073
21267068
21491433

Gene Ontology  (GO ID)

Biological Process

GO:0006699  bile acid biosynthetic process
GO:0030573  bile acid catabolic process
GO:0006707  cholesterol catabolic process
GO:0007586  digestion
GO:0016042  lipid catabolic process
GO:0006629  lipid metabolic process
GO:0055114  oxidation reduction
GO:0008202  steroid metabolic process

Cellular Component

GO:0005783  endoplasmic reticulum
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane

Molecular Function

GO:0033782  24-hydroxycholesterol 7alpha-hydroxylase activity
GO:0009055  electron carrier activity
GO:0020037  heme binding
GO:0005506  iron ion binding
GO:0046872  metal ion binding
GO:0004497  monooxygenase activity
GO:0016491  oxidoreductase activity
GO:0016705  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0008396  oxysterol 7-alpha-hydroxylase activity
GO:0008387  steroid 7-alpha-hydroxylase activity