RIKEN cDNA B230120H23 gene

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Synonym

AV006891, B230120H23Rik, Mixed lineage kinase-related kinase, Leucine zipper-and sterile alpha motif kinase ZAK, MLK-related kinase, Mitogen-activated protein kinase kinase kinase MLT, MLTKbeta, Mltk, MLTKalpha, MLTK, RIKEN cDNA B230120H23 gene, MLK-like mitogen-activated protein triple kinase, Zak, MRK

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:- retina:- eye:7.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:12.80 adipose:- bone:12.50 skin:7.90
GeneChip cerebrum:4.45 cerebellum:4.47 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.50 spine:4.45 retina:4.72 eye:5.01 artery/aorta:- vein:5.40 lymphnode:5.01 peripheral blood:- spleen:4.87 thymus:- bone marrow:6.64 adipose:5.12 bone:5.96 skin:6.22
CAGE cerebrum:2.17 cerebellum:- brain stem:2.41 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.70 retina:- eye:- artery/aorta:4.17 vein:- lymphnode:3.38 peripheral blood:- spleen:3.40 thymus:2.44 bone marrow:- adipose:- bone:4.08 skin:4.29
RNA-seq cerebrum:1.11 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:30.90 ovary:- testis:- heart:37.20 muscle:213 esophagus:- stomach:- intestine:37 colon:-     liver/hepato:-        lung:-    bladder:264.70 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:37.50 breast:9.80 salivary:-
GeneChip uterus:5.42 placenta:4.83 prostate:5.78 ovary:5.16 testis:4.38 heart:4.80 muscle:4.79 esophagus:- stomach:5.54 intestine:5.76 colon:- liver/hepato:5.82 lung:6.21 bladder:4.99 kidney:5.19 pituitary:4.55 thyroid/parathyroid:- adrenal gland:4.96 pancreas:5.30 breast:4.98 salivary:4.69
CAGE uterus:3.82 placenta:2.36 prostate:3.22 ovary:3.65 testis:0.75 heart:- muscle:- esophagus:- stomach:3.51 intestine:3.12 colon:3.24     liver/hepato:2.60    lung:4.06 bladder:4.80 kidney:- pituitary:2.01 thyroid/parathyroid:- adrenal gland:2.75 pancreas:1.84 breast:3.04 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.81 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.25        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_023057
Gene ID 65964
Unigene ID Mm.440210
Probe set ID 1418943_at  [Mouse430_2]
Ensembl ID ENSMUSG00000004085

Orthologous Gene

Human[2]  NM_016653, NM_133646
Rat[2]  NM_016653, NM_133646

Chromosomal Region

2C3  [72,123,694  -  72,280,667]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001660  Sterile alpha motif
IPR010993  Sterile alpha motif homology
IPR013761  Sterile alpha motif-type
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8889548
9184912
10349636
11042159
11042189
11076861
11217851
12466851
12477932
12761180
14610273
15489334
15684425
15737997
16141072
16141073
18287559
18554416

Gene Ontology  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0007049  cell cycle
GO:0007050  cell cycle arrest
GO:0000075  cell cycle checkpoint
GO:0007010  cytoskeleton organization
GO:0000077  DNA damage checkpoint
GO:0016310  phosphorylation
GO:0043065  positive regulation of apoptosis
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0009314  response to radiation

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0000287  magnesium ion binding
GO:0004709  MAP kinase kinase kinase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups