WW domain containing E3 ubiquitin protein ligase 2

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Synonym

WW domain containing E3 ubiquitin protein ligase 2, AIP2, AA690238, 1300010O06Rik, NEDD4-like E3 ubiquitin-protein ligase WWP2, Wwp2, WW domain-containing protein 2, AW554328

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:128.50 cerebellum:165.80 brain stem:95.30 corpus callosum/glia:- pineal gland:257.80 peripheral nerve:57.30 spine:378.30 retina:160.70 eye:91.20 artery/aorta:506.30 vein:- lymphnode:32.40 peripheral blood:230 spleen:316 thymus:247 bone marrow:141 adipose:- bone:475.90 skin:182.10
GeneChip cerebrum:7 cerebellum:7.06 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.63 spine:7.24 retina:7.58 eye:7.47 artery/aorta:- vein:6.80 lymphnode:7.27 peripheral blood:- spleen:7.51 thymus:- bone marrow:7.87 adipose:6.67 bone:7.63 skin:7.47
CAGE cerebrum:2.84 cerebellum:- brain stem:3.04 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.21 retina:- eye:- artery/aorta:3.70 vein:- lymphnode:3.52 peripheral blood:- spleen:3.65 thymus:3.63 bone marrow:- adipose:- bone:4.01 skin:3.50
RNA-seq cerebrum:5.15 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:13.80 prostate:30.90 ovary:46 testis:96.10 heart:18.60 muscle:71 esophagus:- stomach:32.70 intestine:- colon:17.60     liver/hepato:63.40        lung:261.10    bladder:132.40 kidney:64.50 pituitary:167.90 thyroid/parathyroid:- adrenal gland:424.40 pancreas:103.20 breast:284 salivary:-
GeneChip uterus:7.30 placenta:6.51 prostate:7.20 ovary:7.11 testis:6.54 heart:6.91 muscle:6.52 esophagus:- stomach:7.07 intestine:7.69 colon:- liver/hepato:6.82 lung:7.12 bladder:6.85 kidney:7.33 pituitary:7.18 thyroid/parathyroid:- adrenal gland:7.12 pancreas:7.22 breast:6.75 salivary:7.07
CAGE uterus:3.32 placenta:2.70 prostate:3.16 ovary:3.27 testis:3.00 heart:- muscle:- esophagus:- stomach:3.13 intestine:3.49 colon:3.84     liver/hepato:2.58    lung:3.22 bladder:3.15 kidney:- pituitary:2.91 thyroid/parathyroid:- adrenal gland:2.84 pancreas:2.66 breast:2.78 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.34 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.41        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_025830
Gene ID 66894
Unigene ID Mm.390058
Probe set ID 1448146_at  [Mouse430_2]
Ensembl ID ENSMUSG00000031930

Orthologous Gene

Human[3]  NM_007014, NM_199423, NM_199424
Rat[1]  NM_001106184, NM_199423, NM_199424

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR001202  WW/Rsp5/WWP

Link to Pubmed  (Pubmed ID)

8889548
10349636
10903445
10922068
11042159
11076861
11217851
12466851
12477932
12520002
12904583
14610273
15047715
15328020
15328023
15489334
15761153
15782199
16141072
16141073
17526739
17967808
18776082
18799693
19651900
19997087
21170031
21267068
21427722
21847096
21872590
22912667
23479606
24365151

Gene Ontology  (GO ID)

Biological Process

GO:0010629  negative regulation of gene expression
GO:0051224  negative regulation of protein transport
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0032410  negative regulation of transporter activity
GO:0043161  proteasomal ubiquitin-dependent protein catabolic process
GO:0070534  protein K63-linked ubiquitination
GO:0016567  protein ubiquitination
GO:0042787  protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0034765  regulation of ion transmembrane transport
GO:0042391  regulation of membrane potential

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0016874  ligase activity
GO:0008134  transcription factor binding
GO:0004842  ubiquitin-protein ligase activity