dual specificity phosphatase 19

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Synonym

C79103, 5930436K22Rik, Dusp19, SKRP1, Protein phosphatase SKRP1, TS-DSP1, Skrp1, Dual specificity protein phosphatase 19, dual specificity phosphatase 19

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:34.70 cerebellum:- brain stem:63.60 corpus callosum/glia:- pineal gland:- peripheral nerve:19.10 spine:- retina:128.60 eye:15.20 artery/aorta:84.40 vein:- lymphnode:172.80 peripheral blood:- spleen:13.20 thymus:29.60 bone marrow:- adipose:- bone:50.10 skin:23.80
GeneChip cerebrum:7.92 cerebellum:7.19 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.63 spine:8.31 retina:7.62 eye:8.22 artery/aorta:- vein:8.20 lymphnode:7.90 peripheral blood:- spleen:7.85 thymus:- bone marrow:7.50 adipose:8.65 bone:7.51 skin:7.88
CAGE cerebrum:0.23 cerebellum:- brain stem:0.90 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.66 retina:- eye:- artery/aorta:0.14 vein:- lymphnode:0.23 peripheral blood:- spleen:0.16 thymus:0.27 bone marrow:- adipose:- bone:0 skin:0
RNA-seq cerebrum:2.21 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:- ovary:11.50 testis:14.80 heart:- muscle:- esophagus:- stomach:32.70 intestine:- colon:-     liver/hepato:-        lung:40.20    bladder:- kidney:16.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:9.40 breast:42.40 salivary:-
GeneChip uterus:7.81 placenta:8.26 prostate:7.92 ovary:8.04 testis:9.41 heart:8.53 muscle:8.72 esophagus:- stomach:8.10 intestine:8.16 colon:- liver/hepato:8.04 lung:7.78 bladder:7.97 kidney:8.32 pituitary:8.56 thyroid/parathyroid:- adrenal gland:7.91 pancreas:8.29 breast:8.16 salivary:7.37
CAGE uterus:0 placenta:0.11 prostate:0.20 ovary:0.13 testis:0 heart:- muscle:- esophagus:- stomach:0 intestine:0 colon:0.23     liver/hepato:0    lung:0.17 bladder:0.33 kidney:- pituitary:0.29 thyroid/parathyroid:- adrenal gland:0 pancreas:0 breast:0.12 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:6.30 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.41        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_024438
Gene ID 68082
Unigene ID Mm.306818
Probe set ID 1418038_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000027001

Orthologous Gene

Human[2]  NM_001142314, NM_080876
Rat[1]  NM_001107739, NM_080876

Chromosomal Region

-

Gene Family (Interpro ID)

IPR020417  Dual specificity phosphatase
IPR000340  Dual specificity phosphatase, catalytic domain
IPR020422  Dual specificity phosphatase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8889548
10349636
10725249
10922068
11042159
11076861
11217851
11432789
11959861
11959862
12466851
12477932
16141072
16141073

Gene Ontology  (GO ID)

Biological Process

GO:0016311  dephosphorylation
GO:0000188  inactivation of MAPK activity
GO:0007254  JNK cascade
GO:0046329  negative regulation of JNK cascade
GO:0043508  negative regulation of JUN kinase activity
GO:0006469  negative regulation of protein kinase activity
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0045860  positive regulation of protein kinase activity
GO:0006470  protein amino acid dephosphorylation

Cellular Component

GO:0005737  cytoplasm

Molecular Function

GO:0016787  hydrolase activity
GO:0008579  JUN kinase phosphatase activity
GO:0005078  MAP-kinase scaffold activity
GO:0031434  mitogen-activated protein kinase kinase binding
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0016791  phosphatase activity
GO:0004721  phosphoprotein phosphatase activity
GO:0005515  protein binding
GO:0030295  protein kinase activator activity
GO:0004860  protein kinase inhibitor activity
GO:0004725  protein tyrosine phosphatase activity
GO:0008138  protein tyrosine/serine/threonine phosphatase activity
GO:0008330  protein tyrosine/threonine phosphatase activity