vaccinia related kinase 2

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Synonym

2810003O05Rik, Serine/threonine-protein kinase VRK2, Vrk2, Vaccinia-related kinase 2, vaccinia related kinase 2, AI447698

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:10.80 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.98 cerebellum:5 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.28 spine:5.08 retina:5.12 eye:5.76 artery/aorta:- vein:6.56 lymphnode:9.16 peripheral blood:- spleen:8.19 thymus:- bone marrow:8.48 adipose:6.55 bone:8.36 skin:6.83
CAGE cerebrum:1.05 cerebellum:- brain stem:1.46 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.82 retina:- eye:- artery/aorta:2.71 vein:- lymphnode:4.20 peripheral blood:- spleen:3.47 thymus:3.47 bone marrow:- adipose:- bone:3.35 skin:2.65
RNA-seq cerebrum:0.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:6.21 placenta:6.26 prostate:6.63 ovary:6.20 testis:7.78 heart:6.12 muscle:6.78 esophagus:- stomach:6.18 intestine:6.44 colon:- liver/hepato:6.17 lung:6.08 bladder:6.66 kidney:5.78 pituitary:6.04 thyroid/parathyroid:- adrenal gland:5.78 pancreas:5.59 breast:6.54 salivary:6.74
CAGE uterus:2.47 placenta:2.20 prostate:1.69 ovary:2.56 testis:2.64 heart:- muscle:- esophagus:- stomach:2.73 intestine:2.33 colon:2.19     liver/hepato:2.60    lung:2.74 bladder:2.70 kidney:- pituitary:2.35 thyroid/parathyroid:- adrenal gland:2.39 pancreas:1.84 breast:2.50 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.90 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.50        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_027260
Gene ID 69922
Unigene ID Mm.285351
Probe set ID 1453343_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000064090

Orthologous Gene

Human[5]  NM_001130480, NM_001130481, NM_001130482, NM_001130483, NM_006296
Rat[1]  NM_001108366, NM_001130481, NM_001130482, NM_001130483, NM_006296

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain

Link to Pubmed  (Pubmed ID)

8889548
10349636
11042159
11076861
11217851
12417526
12466851
12477932
12782311
14645249
15489334
15782199
16141072
16141073
16462940
16919269
17709393
21267068
21677750
22572157

Gene Ontology  (GO ID)

Biological Process

GO:0034599  cellular response to oxidative stress
GO:0016310  phosphorylation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0043408  regulation of MAPKKK cascade

Cellular Component

GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0031966  mitochondrial membrane
GO:0005739  mitochondrion
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups