Rap guanine nucleotide exchange factor (GEF) 2

 jump to detail

Synonym

mKIAA0313, Neural RAP guanine nucleotide exchange protein, Rap guanine nucleotide exchange factor 2, Rap guanine nucleotide exchange factor (GEF) 2, nRap GEP, 5830453M24Rik, Rapgef2, PDZ-GEF1, Pdzgef1, Kiaa0313

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip nodata
CAGE cerebrum:1.85 cerebellum:- brain stem:2.31 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.55 retina:- eye:- artery/aorta:2.25 vein:- lymphnode:2.01 peripheral blood:- spleen:1.36 thymus:0.95 bone marrow:- adipose:- bone:0.63 skin:1.91
RNA-seq cerebrum:5.31 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip nodata
CAGE uterus:2.10 placenta:1.27 prostate:0.63 ovary:1.55 testis:0.75 heart:- muscle:- esophagus:- stomach:2.04 intestine:0.42 colon:1.27     liver/hepato:0.47    lung:2.70 bladder:1.41 kidney:- pituitary:0.86 thyroid/parathyroid:- adrenal gland:0.91 pancreas:1.30 breast:1.29 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.63 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.45        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001099624
Gene ID 76089
Unigene ID -
Probe set ID -
Ensembl ID ENSMUSG00000062232

Orthologous Gene

Human[3]  NM_014247
Rat[1]  NM_001107684

Chromosomal Region

3E3  [78,866,438  -  78,985,262]

Gene Family (Interpro ID)

IPR000595  Cyclic nucleotide-binding
IPR018490  Cyclic nucleotide-binding-like
IPR014710  RmlC-like jelly roll fold

Link to Pubmed  (Pubmed ID)

8889548
10349636
11042159
11076861
11217851
12465718
12466851
12477932
12520002
16141072
16141073
16272156
16602821
16959763
17826737
19453629
19635461
20595512
21267068
21677750
21864586
23800469

Gene Ontology  (GO ID)

Biological Process

GO:0032854  positive regulation of Rap GTPase activity
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0048167  regulation of synaptic plasticity
GO:0007165  signal transduction
GO:0007264  small GTPase mediated signal transduction

Cellular Component

GO:0005622  intracellular
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005085  guanyl-nucleotide exchange factor activity
GO:0019901  protein kinase binding
GO:0046582  Rap GTPase activator activity
GO:0017034  Rap guanyl-nucleotide exchange factor activity