dihydropyrimidine dehydrogenase

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Synonym

DPD, dihydropyrimidine dehydrogenase, E330028L06Rik, Dpyd, AI315208, MGC37940

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.63 cerebellum:4.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.67 spine:5.58 retina:6.52 eye:6.39 artery/aorta:- vein:4.34 lymphnode:6.09 peripheral blood:- spleen:4.95 thymus:- bone marrow:3.87 adipose:8.80 bone:4.61 skin:5.42
CAGE cerebrum:2.39 cerebellum:- brain stem:2.52 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.89 retina:- eye:- artery/aorta:3.95 vein:- lymphnode:2.43 peripheral blood:- spleen:0.93 thymus:1.69 bone marrow:- adipose:- bone:0.63 skin:3.39
RNA-seq cerebrum:2.16 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.12 placenta:4.72 prostate:7.81 ovary:7.83 testis:5.15 heart:7.20 muscle:5.81 esophagus:- stomach:7.31 intestine:9.40 colon:- liver/hepato:12.53 lung:7.25 bladder:7.42 kidney:9.69 pituitary:6.58 thyroid/parathyroid:- adrenal gland:8.25 pancreas:4.77 breast:6.60 salivary:9.82
CAGE uterus:2.97 placenta:0.55 prostate:2.64 ovary:3.23 testis:0.99 heart:- muscle:- esophagus:- stomach:2.16 intestine:5.16 colon:5.20     liver/hepato:6.26    lung:2.06 bladder:2.89 kidney:- pituitary:3.42 thyroid/parathyroid:- adrenal gland:3.43 pancreas:2.45 breast:1.93 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.23 esophagus:- stomach:- intestine:- colon:-     liver/hepato:30.01        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_170778
Gene ID 99586
Unigene ID -
Probe set ID 1427946_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000033308

Orthologous Gene

Human[2]  NM_000110, NM_001160301
Rat[2]  NM_000110, NM_001160301

Chromosomal Region

-

Gene Family (Interpro ID)

IPR013027  FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR000103  Pyridine nucleotide-disulphide oxidoreductase, class-II

Link to Pubmed  (Pubmed ID)

8889548
10349636
11042159
11076861
11217851
12466851
12477932
12527935
12651209
14681479
16141072
16141073
21267068
21677750
22008794

Gene Ontology  (GO ID)

Biological Process

GO:0007623  circadian rhythm
GO:0055114  oxidation reduction
GO:0006145  purine base catabolic process
GO:0006208  pyrimidine base catabolic process
GO:0042493  response to drug
GO:0007584  response to nutrient
GO:0006214  thymidine catabolic process
GO:0006210  thymine catabolic process
GO:0006222  UMP biosynthetic process
GO:0006212  uracil catabolic process
GO:0019860  uracil metabolic process

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol

Molecular Function

GO:0051539  4 iron, 4 sulfur cluster binding
GO:0003824  catalytic activity
GO:0004152  dihydroorotate dehydrogenase activity
GO:0004158  dihydroorotate oxidase activity
GO:0017113  dihydropyrimidine dehydrogenase (NADP+) activity
GO:0009055  electron carrier activity
GO:0051536  iron-sulfur cluster binding
GO:0046872  metal ion binding
GO:0050661  NADP or NADPH binding
GO:0000166  nucleotide binding
GO:0016491  oxidoreductase activity
GO:0042803  protein homodimerization activity
GO:0002058  uracil binding