Tnf receptor-associated factor 3

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:234 thymus:122.90 bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:189.80 ovary:- testis:82.30 heart:116.30 muscle:- esophagus:- stomach:1077.60 intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001108724
Gene ID 362788
Unigene ID Rn.12033
Probe set ID -
Ensembl ID ENSRNOG00000008145

Orthologous Gene

Human[3]  NM_001199427, NM_003300, NM_145725, NM_145726
Mouse[4]  NM_001048206, NM_011632, NM_145725, NM_145726

Chromosomal Region

6q32  [135,925,375  -  136,025,587]

Gene Family (Interpro ID)

IPR002083  MATH
IPR012227  TNF receptor-associated factor TRAF
IPR008974  TRAF-like
IPR018957  Zinc finger, C3HC4 RING-type
IPR013083  Zinc finger, RING/FYVE/PHD-type

Link to Pubmed  (Pubmed ID)

17626074
21235323
22871113

Gene Ontology  (GO ID)

Biological Process

GO:0008150  biological_process
GO:0045087  innate immune response
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0042981  regulation of apoptosis
GO:0001817  regulation of cytokine production
GO:0050688  regulation of defense response to virus
GO:0032648  regulation of interferon-beta production
GO:0030162  regulation of proteolysis
GO:0008063  Toll signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0033209  tumor necrosis factor-mediated signaling pathway

Cellular Component

GO:0005575  cellular_component
GO:0009898  internal side of plasma membrane

Molecular Function

GO:0003674  molecular_function
GO:0019901  protein kinase binding
GO:0031996  thioesterase binding
GO:0031625  ubiquitin protein ligase binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding