toll-like receptor 3

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:114.10 testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_198791
Gene ID 364594
Unigene ID Rn.15273
Probe set ID -
Ensembl ID ENSRNOG00000021726

Orthologous Gene

Human[1]  NM_003265
Mouse[2]  NM_126166

Chromosomal Region

16q11  [50,112,910  -  50,126,365]

Gene Family (Interpro ID)

IPR004075  Interleukin-1 receptor, type I/Toll precursor
IPR000157  Toll-Interleukin receptor

Link to Pubmed  (Pubmed ID)

11607032
14987294
15661832
15920723
16027122
16029432
16146574
16424225
16453294
16638093
16789835
16973131
17027917
17434873
17610940
18097050
18223009
18592153
18654661
18849495
19009529
19115402
19608731
19703144
19752565
19779466
20011045
20473890
20500834
20638911
20692254
20848777
20935192
20937230
21129050
21235323
21342497
21355876
21364926
21708001
21848608
22647506
22681877
22702720
23372055
23558035
23908180
23946637
23981041
24729619

Gene Ontology  (GO ID)

Biological Process

GO:0071359  cellular response to dsRNA
GO:0071360  cellular response to exogenous dsRNA
GO:0071346  cellular response to interferon-gamma
GO:0071260  cellular response to mechanical stimulus
GO:0006952  defense response
GO:0051607  defense response to virus
GO:0007252  I-kappaB phosphorylation
GO:0008584  male gonad development
GO:0002282  microglial cell activation during immune response
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0052033  pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity
GO:0043065  positive regulation of apoptosis
GO:0045080  positive regulation of chemokine biosynthetic process
GO:0032722  positive regulation of chemokine production
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050729  positive regulation of inflammatory response
GO:0045356  positive regulation of interferon-alpha biosynthetic process
GO:0045359  positive regulation of interferon-beta biosynthetic process
GO:0032728  positive regulation of interferon-beta production
GO:0045078  positive regulation of interferon-gamma biosynthetic process
GO:0032735  positive regulation of interleukin-12 production
GO:0032755  positive regulation of interleukin-6 production
GO:0032757  positive regulation of interleukin-8 production
GO:0046330  positive regulation of JNK cascade
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0034123  positive regulation of toll-like receptor signaling pathway
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032760  positive regulation of tumor necrosis factor production
GO:0032481  positive regulation of type I interferon production
GO:0034346  positive regulation of type III interferon production
GO:0043331  response to dsRNA
GO:0043330  response to exogenous dsRNA
GO:0009615  response to virus
GO:0034138  toll-like receptor 3 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0016021  integral to membrane
GO:0005622  intracellular

Molecular Function

GO:0003725  double-stranded RNA binding
GO:0004872  receptor activity
GO:0004888  transmembrane receptor activity