protein disulfide isomerase family A, member 6

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Synonym

Thioredoxin domain-containing protein 7, P5, protein disulfide isomerase family A, member 6, TXNDC7, PDIA6, protein disulfide isomerase-associated 6, Protein disulfide isomerase P5, ERP5, Protein disulfide-isomerase A6 precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:167.10 cerebellum:63 brain stem:- corpus callosum/glia:349.90 pineal gland:148.30 peripheral nerve:337.40 spine:112.30 retina:355.90 eye:135.20 artery/aorta:449.60 vein:399.90 lymphnode:101.10 peripheral blood:309.70 spleen:94.50 thymus:64.40 bone marrow:78.70 adipose:80.70 bone:307.10 skin:292.80
GeneChip cerebrum:7.12 cerebellum:6.94 brain stem:7.09 corpus callosum/glia:7.43 pineal gland:- peripheral nerve:7.89 spine:7.66 retina:- eye:- artery/aorta:7.99 vein:7.81 lymphnode:8.59 peripheral blood:- spleen:8.68 thymus:8.26 bone marrow:8.32 adipose:8.32 bone:- skin:7.95
CAGE cerebrum:3.77 cerebellum:- brain stem:3.82 corpus callosum/glia:3.78 pineal gland:3.95 peripheral nerve:- spine:3.68 retina:- eye:- artery/aorta:4.33 vein:3.87 lymphnode:4.59 peripheral blood:- spleen:4.65 thymus:3.84 bone marrow:- adipose:4.44 bone:- skin:-
RNA-seq cerebrum:4.79 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:6.97 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:6.07 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:373.60 placenta:437.20 prostate:259.10 ovary:260.80 testis:142.80 heart:242.70 muscle:60.30 esophagus:342.80 stomach:254.90 intestine:421.20 colon:245.90     liver/hepato:147.80        lung:303    bladder:879.30 kidney:176.80 pituitary:116 thyroid/parathyroid:818.70 adrenal gland:304.70 pancreas:231.20 breast:316 salivary:328.40
GeneChip uterus:8.88 placenta:8.89 prostate:9.02 ovary:8.92 testis:7.72 heart:8.38 muscle:7.25 esophagus:8.40 stomach:8.99 intestine:8.98 colon:8.82 liver/hepato:8.82 lung:8.46 bladder:- kidney:8.49 pituitary:8.47 thyroid/parathyroid:9.85 adrenal gland:8.67 pancreas:9.80 breast:8.34 salivary:9.32
CAGE uterus:4.29 placenta:4.75 prostate:4.19 ovary:4.27 testis:3.92 heart:4.45 muscle:3.49 esophagus:4.14 stomach:- intestine:4.45 colon:4.28     liver/hepato:5.73    lung:4.27 bladder:4.20 kidney:4.83 pituitary:4.04 thyroid/parathyroid:5.64 adrenal gland:- pancreas:5.98 breast:4.59 salivary:5.07
RNA-seq uterus:- placenta:- prostate:6.53 ovary:6.85 testis:6.45 heart:5.28 muscle:5.14 esophagus:- stomach:- intestine:- colon:6.98     liver/hepato:7.92        lung:6.34    bladder:- kidney:7.33 pituitary:- thyroid/parathyroid:8.23 adrenal gland:7.07 pancreas:- breast:6.22 salivary:-

Gene Information

IDs

Refseq ID NM_005742
Gene ID 10130
Unigene ID Hs.212102
Probe set ID 207668_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000143870
GTEx ID ENSG00000143870

Orthologous Gene

Mouse[1]  NM_027959
Rat [0]  

Chromosomal Region

2p25.1  [10,923,517  -  10,978,103]

Gene Family (Interpro ID)

IPR005788  Disulphide isomerase
IPR013766  Thioredoxin domain
IPR012335  Thioredoxin fold
IPR017936  Thioredoxin-like
IPR012336  Thioredoxin-like fold

Link to Pubmed  (Pubmed ID)

1602151
7590364
8125298
8619474
9110174
12204115
12218051
12218052
12477932
12643545
14702039
15280358
15302935
15308636
15466936
15489334
15644496
15952740
16130169
16182193
16236267
16344560
16396496
16964243
17081065
17081983
17215244
17301129
17353931
17495932
18187620
18781797
19135240
19738201
19887585
20000738
20360068
20379614
20458450
21081666
21103663
21110914
21139048
21145461
21319273
21890473
21906983
21988832
22113938
22167753
22190034
22215138
22230366
22268729
22645275
22863883
22936677
22939629
23000965
23142642
23184937
23206338
23349634
23463506
23798571
23862649
24244333
24583282
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006987  activation of signaling protein activity involved in unfolded protein response
GO:0045454  cell redox homeostasis
GO:0044267  cellular protein metabolic process
GO:0030968  endoplasmic reticulum unfolded protein response
GO:0006662  glycerol ether metabolic process
GO:0006457  protein folding

Cellular Component

GO:0005783  endoplasmic reticulum
GO:0005788  endoplasmic reticulum lumen
GO:0005789  endoplasmic reticulum membrane
GO:0005793  ER-Golgi intermediate compartment
GO:0042470  melanosome
GO:0005886  plasma membrane

Molecular Function

GO:0009055  electron carrier activity
GO:0005515  protein binding
GO:0003756  protein disulfide isomerase activity
GO:0015035  protein disulfide oxidoreductase activity