cyclin-dependent kinase 5

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Synonym

Tau protein kinase II catalytic subunit, PSSALRE, CDK5, TPKII catalytic subunit, Serine/threonine-protein kinase PSSALRE, Cell division protein kinase 5, cyclin-dependent kinase 5

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.71 cerebellum:6.98 brain stem:7.66 corpus callosum/glia:6.30 pineal gland:- peripheral nerve:7.48 spine:6.77 retina:- eye:- artery/aorta:5.77 vein:5.69 lymphnode:5.98 peripheral blood:- spleen:5.58 thymus:5.94 bone marrow:5.88 adipose:5.95 bone:- skin:5.95
CAGE cerebrum:3.66 cerebellum:- brain stem:3.26 corpus callosum/glia:2.84 pineal gland:3.10 peripheral nerve:- spine:2.68 retina:- eye:- artery/aorta:2.17 vein:2.03 lymphnode:1.96 peripheral blood:- spleen:2.47 thymus:2.67 bone marrow:- adipose:2.07 bone:- skin:-
RNA-seq cerebrum:1.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.65 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.09 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.77 placenta:5.45 prostate:5.94 ovary:5.44 testis:5.73 heart:5.63 muscle:5.71 esophagus:6.08 stomach:5.84 intestine:5.93 colon:6 liver/hepato:5.98 lung:5.87 bladder:- kidney:6.43 pituitary:6.88 thyroid/parathyroid:5.97 adrenal gland:6.29 pancreas:6.10 breast:6.07 salivary:6.29
CAGE uterus:1.76 placenta:2.26 prostate:2.14 ovary:1.54 testis:2.21 heart:1.88 muscle:1.15 esophagus:2.14 stomach:- intestine:2.33 colon:2.04     liver/hepato:2.34    lung:2.17 bladder:1.75 kidney:2.62 pituitary:2.53 thyroid/parathyroid:2.33 adrenal gland:- pancreas:1.87 breast:1.92 salivary:2.35
RNA-seq uterus:- placenta:- prostate:1.11 ovary:0.16 testis:0.50 heart:0.00 muscle:0.29 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.65        lung:0.21    bladder:- kidney:0.17 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.62 pancreas:- breast:0.06 salivary:-

IDs

Refseq ID NM_001164410
Gene ID 1020
Unigene ID Hs.647078
Probe set ID 204247_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000164885
GTEx ID ENSG00000164885

Orthologous Gene

Mouse[2]  NM_007668
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1181841
1330687
1639063
7566346
7834371
7949095
8090221
8090222
8275715
8702879
8764598
8891282
9013862
9038181
9150368
9199504
9244350
9353289
9396813
9422379
9478941
9545286
9546672
9565682
9596352
9614189
9735171
9771888
9832145
10049762
10500146
10544291
10604473
10683146
10721722
10762698
10884347
10896159
10915792
10936190
10995546
11104762
11113134
11163260
11168528
11181841
11254741
11278541
11311121
11320080
11389014
11483158
11516829
11583627
11604394
11675505
11684694
11733001
11741927
11743029
11784720
11823425
11865137
11882646
11955625
12056836
12064478
12071639
12077184
12084709
12154070
12223541
12226093
12372285
12372407
12387894
12435421
12477932
12491158
12690205
12691662
12765608
12769842
12796778
12824184
12826674
12832492
12832520
12855954
12963086
12970441
12972605
14521924
14704270
14741103
15013773
15030318
15123618
15178331
15342556
15345747
15489224
15489334
15492003
15652488
15741232
15790807
15834155
15890360
15911879
15917097
16327995
16356933
16407256
16413130
16519508
16712791
16862120
17036052
17045592
17060323
17078951
17121855
17145757
17290217
17327227
17419807
17491008
17493033
17581253
17591690
17611284
17713927
17762160
17906618
18042622
18076569
18247371
18326489
18350355
18408012
18460467
18480410
18487454
18490454
18598350
18676680
19001851
19050041
19170196
19343042
19363486
19514266
19514267
19514268
19615060
19625176
19692168
19693690
19700222
19718565
19764350
19822667
19913121
19953087
19960242
20013135
20133653
20213743
20234188
20345761
20354813
20357208
20360068
20379614
20453000
20491486
20516069
20628086
20651683
20673369
20720012
20826806
21044075
21139048
21145489
21163940
21209322
21220307
21289309
21335063
21415596
21435449
21465480
21482751
21600237
21671254
21701498
21712386
21741478
21799006
21825040
21832049
21844361
21890473
21900206
21922195
21924349
21963094
21987572
22078880
22223639
22505724
22547140
22654103
22696682
22753194
22768111
22778260
22829587
22833568
22874667
22899714
22939629
22964075
22990118
23206597
23332172
23362255
23377270
23401660
23455922
23543736
23602568
23728742
23941877
23955241
24085300
24091658
24098701
24121667
24135281
24235147
24447338
24607229
24797263
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0048675  axon extension
GO:0007411  axon guidance
GO:0048148  behavioral response to cocaine
GO:0007596  blood coagulation
GO:0070509  calcium ion import
GO:0051301  cell division
GO:0008283  cell proliferation
GO:0007160  cell-matrix adhesion
GO:0021954  central nervous system neuron development
GO:0021697  cerebellar cortex formation
GO:0022038  corpus callosum development
GO:0030866  cortical actin cytoskeleton organization
GO:0048813  dendrite morphogenesis
GO:0009790  embryonic development
GO:0021766  hippocampus development
GO:0006886  intracellular protein transport
GO:0021819  layer formation in the cerebral cortex
GO:0008045  motor axon guidance
GO:0030517  negative regulation of axon extension
GO:0045786  negative regulation of cell cycle
GO:0046826  negative regulation of protein export from nucleus
GO:0031397  negative regulation of protein ubiquitination
GO:0031914  negative regulation of synaptic plasticity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0051402  neuron apoptosis
GO:0030182  neuron differentiation
GO:0001764  neuron migration
GO:0031175  neuron projection development
GO:0006913  nucleocytoplasmic transport
GO:0048709  oligodendrocyte differentiation
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0016310  phosphorylation
GO:0045956  positive regulation of calcium ion-dependent exocytosis
GO:0043525  positive regulation of neuron apoptosis
GO:0032092  positive regulation of protein binding
GO:0045860  positive regulation of protein kinase activity
GO:0046777  protein amino acid autophosphorylation
GO:0032801  receptor catabolic process
GO:0043113  receptor clustering
GO:0045055  regulated secretory pathway
GO:0042981  regulation of apoptosis
GO:0071156  regulation of cell cycle arrest
GO:0030334  regulation of cell migration
GO:0060079  regulation of excitatory postsynaptic membrane potential
GO:0048167  regulation of synaptic plasticity
GO:0014044  Schwann cell development
GO:0019233  sensory perception of pain
GO:0033136  serine phosphorylation of STAT3 protein
GO:0007519  skeletal muscle tissue development
GO:0007416  synapse assembly
GO:0007268  synaptic transmission
GO:0001963  synaptic transmission, dopaminergic
GO:0035249  synaptic transmission, glutamatergic
GO:0048488  synaptic vesicle endocytosis
GO:0016079  synaptic vesicle exocytosis
GO:0008542  visual learning

Cellular Component

GO:0030424  axon
GO:0030054  cell junction
GO:0043025  cell soma
GO:0016533  cyclin-dependent protein kinase 5 holoenzyme complex
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030425  dendrite
GO:0030175  filopodium
GO:0030426  growth cone
GO:0030027  lamellipodium
GO:0016020  membrane
GO:0031594  neuromuscular junction
GO:0005634  nucleus
GO:0043204  perikaryon
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane

Molecular Function

GO:0030549  acetylcholine receptor activator activity
GO:0005524  ATP binding
GO:0004693  cyclin-dependent protein kinase activity
GO:0046875  ephrin receptor binding
GO:0005176  ErbB-2 class receptor binding
GO:0043125  ErbB-3 class receptor binding
GO:0016301  kinase activity
GO:0002039  p53 binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0050321  tau-protein kinase activity