cyclin-dependent kinase 5

Synonym

Tau protein kinase II catalytic subunit, PSSALRE, CDK5, TPKII catalytic subunit, Serine/threonine-protein kinase PSSALRE, Cell division protein kinase 5, cyclin-dependent kinase 5

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:7.71

cerebellum:6.98

brain stem:7.66

corpus callosum/glia:6.30

pineal gland:-

peripheral nerve:7.48

spine:6.77

retina:-

eye:-

artery/aorta:5.77

vein:5.69

lymphnode:5.98

peripheral blood:-

spleen:5.58

thymus:5.94

bone marrow:5.88

adipose:5.95

bone:-

skin:5.95

CAGE

cerebrum:3.66

cerebellum:-

brain stem:3.26

corpus callosum/glia:2.84

pineal gland:3.10

peripheral nerve:-

spine:2.68

retina:-

eye:-

artery/aorta:2.17

vein:2.03

lymphnode:1.96

peripheral blood:-

spleen:2.47

thymus:2.67

bone marrow:-

adipose:2.07

bone:-

skin:-

RNA-seq

cerebrum:4.24

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.38

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.68

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.77

placenta:5.45

prostate:5.94

ovary:5.44

testis:5.73

heart:5.63

muscle:5.71

esophagus:6.08

stomach:5.84

intestine:5.93

colon:6

liver/hepato:5.98

lung:5.87

bladder:-

kidney:6.43

pituitary:6.88

thyroid/parathyroid:5.97

adrenal gland:6.29

pancreas:6.10

breast:6.07

salivary:6.29

CAGE

uterus:1.76

placenta:2.26

prostate:2.14

ovary:1.54

testis:2.21

heart:1.88

muscle:1.15

esophagus:2.14

stomach:-

intestine:2.33

colon:2.04

liver/hepato:2.34

lung:2.17

bladder:1.75

kidney:2.62

pituitary:2.53

thyroid/parathyroid:2.33

adrenal gland:-

pancreas:1.87

breast:1.92

salivary:2.35

RNA-seq

uterus:-

placenta:-

prostate:1.65

ovary:1.84

testis:2.66

heart:1.45

muscle:1.13

esophagus:-

stomach:-

intestine:-

colon:2.01

liver/hepato:2.10

lung:1.17

bladder:-

kidney:2.61

pituitary:-

thyroid/parathyroid:2.09

adrenal gland:1.83

pancreas:-

breast:2.22

salivary:-

IDs

Refseq ID	NM_004935
Gene ID	1020
Unigene ID	Hs.647078
Probe set ID	204247_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000164885
GTEx ID	ENSG00000164885

Orthologous Gene

Mouse[2]	NM_007668
Rat [0]

Chromosomal Region

7q36.1 [150,750,899 - 150,755,617]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0048675	axon extension
GO:0007411	axon guidance
GO:0048148	behavioral response to cocaine
GO:0007596	blood coagulation
GO:0070509	calcium ion import
GO:0051301	cell division
GO:0008283	cell proliferation
GO:0007160	cell-matrix adhesion
GO:0021954	central nervous system neuron development
GO:0021697	cerebellar cortex formation
GO:0022038	corpus callosum development
GO:0030866	cortical actin cytoskeleton organization
GO:0048813	dendrite morphogenesis
GO:0009790	embryonic development
GO:0021766	hippocampus development
GO:0006886	intracellular protein transport
GO:0021819	layer formation in the cerebral cortex
GO:0008045	motor axon guidance
GO:0030517	negative regulation of axon extension
GO:0045786	negative regulation of cell cycle
GO:0046826	negative regulation of protein export from nucleus
GO:0031397	negative regulation of protein ubiquitination
GO:0031914	negative regulation of synaptic plasticity
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0051402	neuron apoptosis
GO:0030182	neuron differentiation
GO:0001764	neuron migration
GO:0031175	neuron projection development
GO:0006913	nucleocytoplasmic transport
GO:0048709	oligodendrocyte differentiation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0016310	phosphorylation
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0043525	positive regulation of neuron apoptosis
GO:0032092	positive regulation of protein binding
GO:0045860	positive regulation of protein kinase activity
GO:0046777	protein amino acid autophosphorylation
GO:0032801	receptor catabolic process
GO:0043113	receptor clustering
GO:0045055	regulated secretory pathway
GO:0042981	regulation of apoptosis
GO:0071156	regulation of cell cycle arrest
GO:0030334	regulation of cell migration
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0048167	regulation of synaptic plasticity
GO:0014044	Schwann cell development
GO:0019233	sensory perception of pain
GO:0033136	serine phosphorylation of STAT3 protein
GO:0007519	skeletal muscle tissue development
GO:0007416	synapse assembly
GO:0007268	synaptic transmission
GO:0001963	synaptic transmission, dopaminergic
GO:0035249	synaptic transmission, glutamatergic
GO:0048488	synaptic vesicle endocytosis
GO:0016079	synaptic vesicle exocytosis
GO:0008542	visual learning

Cellular Component

GO:0030424	axon
GO:0030054	cell junction
GO:0043025	cell soma
GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030425	dendrite
GO:0030175	filopodium
GO:0030426	growth cone
GO:0030027	lamellipodium
GO:0016020	membrane
GO:0031594	neuromuscular junction
GO:0005634	nucleus
GO:0043204	perikaryon
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0045211	postsynaptic membrane

Molecular Function

GO:0030549	acetylcholine receptor activator activity
GO:0005524	ATP binding
GO:0004693	cyclin-dependent protein kinase activity
GO:0046875	ephrin receptor binding
GO:0005176	ErbB-2 class receptor binding
GO:0043125	ErbB-3 class receptor binding
GO:0016301	kinase activity
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0050321	tau-protein kinase activity

cyclin-dependent kinase 5

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function