proteasome (prosome, macropain) 26S subunit, non-ATPase, 14

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Synonym

PSMD14, 26S proteasome non-ATPase regulatory subunit 14, 26S proteasome regulatory subunit rpn11, POH1, pad1, rpn11, 26S proteasome-associated PAD1 homolog 1, PAD1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:91.30 cerebellum:88.20 brain stem:- corpus callosum/glia:- pineal gland:296.70 peripheral nerve:30.70 spine:- retina:- eye:205.70 artery/aorta:179.90 vein:- lymphnode:91 peripheral blood:72.90 spleen:- thymus:12.90 bone marrow:177.10 adipose:40.30 bone:64 skin:168
GeneChip cerebrum:8.45 cerebellum:8.19 brain stem:8.75 corpus callosum/glia:8.21 pineal gland:- peripheral nerve:8.30 spine:8.55 retina:- eye:- artery/aorta:7.53 vein:8.02 lymphnode:7.84 peripheral blood:- spleen:7.26 thymus:8.54 bone marrow:7.58 adipose:7.93 bone:- skin:8.28
CAGE cerebrum:3.79 cerebellum:- brain stem:3.81 corpus callosum/glia:3.32 pineal gland:3.95 peripheral nerve:- spine:3.94 retina:- eye:- artery/aorta:3.26 vein:3.27 lymphnode:3.67 peripheral blood:- spleen:3.67 thymus:3.59 bone marrow:- adipose:3.54 bone:- skin:-
RNA-seq cerebrum:5.36 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.22 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.86 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:127.60 placenta:102 prostate:135.20 ovary:149.10 testis:64.90 heart:217.10 muscle:60.30 esophagus:- stomach:42.50 intestine:162 colon:135.70     liver/hepato:232.20        lung:68.40    bladder:251.20 kidney:52 pituitary:232 thyroid/parathyroid:327.50 adrenal gland:101.60 pancreas:195.60 breast:185.90 salivary:-
GeneChip uterus:7.98 placenta:7.86 prostate:8.34 ovary:7.92 testis:8.29 heart:7.92 muscle:8.85 esophagus:8.66 stomach:7.67 intestine:8.17 colon:7.31 liver/hepato:7.60 lung:7.56 bladder:- kidney:7.58 pituitary:7.97 thyroid/parathyroid:7.80 adrenal gland:8.11 pancreas:8 breast:7.92 salivary:7.32
CAGE uterus:3.19 placenta:3.53 prostate:3.12 ovary:3.18 testis:3.76 heart:3.48 muscle:4.22 esophagus:3.47 stomach:- intestine:3.33 colon:3.11     liver/hepato:4.01    lung:3.44 bladder:3.10 kidney:3.78 pituitary:3.95 thyroid/parathyroid:3.27 adrenal gland:- pancreas:3.32 breast:3.67 salivary:3.05
RNA-seq uterus:- placenta:- prostate:4.36 ovary:4.86 testis:5.74 heart:4.40 muscle:5.12 esophagus:- stomach:- intestine:- colon:4.62     liver/hepato:5.16        lung:3.88    bladder:- kidney:5.22 pituitary:- thyroid/parathyroid:5.98 adrenal gland:5.40 pancreas:- breast:5.46 salivary:-

Gene Information

IDs

Refseq ID NM_005805
Gene ID 10213
Unigene ID Hs.567410
Probe set ID 212296_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000115233
GTEx ID ENSG00000115233

Orthologous Gene

Mouse[1]  NM_021526
Rat[1]  NM_001025689

Chromosomal Region

2q24.2  [162,164,549  -  162,268,228]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8889548
9374539
11285280
12477932
12791267
12938929
14702039
14737182
15029244
15489334
15592455
16196087
16239144
16344560
16569633
17237285
17323924
17353931
17573772
18029348
18162577
18775730
18781797
18922472
19013454
19193609
19214193
19349277
19380743
19412159
19419512
19471022
19615732
19732767
19781552
19815544
20058232
20656689
21139048
21726808
21733848
21906983
21963094
21987572
21988832
22053931
22118674
22505724
22863883
22909820
22939629
23000965
23438482
23503661
23751493
24429290
24654937

Gene Ontology  (GO ID)

Biological Process

GO:0031145  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590  antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0006915  apoptosis
GO:0034641  cellular nitrogen compound metabolic process
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0000724  double-strand break repair via homologous recombination
GO:0006303  double-strand break repair via nonhomologous end joining
GO:0000082  G1/S transition of mitotic cell cycle
GO:0010467  gene expression
GO:0000278  mitotic cell cycle
GO:0016071  mRNA metabolic process
GO:0043066  negative regulation of apoptosis
GO:0051436  negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0010950  positive regulation of endopeptidase activity
GO:0051437  positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0070536  protein K63-linked deubiquitination
GO:0000209  protein polyubiquitination
GO:0042981  regulation of apoptosis
GO:0006521  regulation of cellular amino acid metabolic process
GO:0051439  regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0016070  RNA metabolic process
GO:0006511  ubiquitin-dependent protein catabolic process
GO:0016032  viral reproduction

Cellular Component

GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0022624  proteasome accessory complex
GO:0000502  proteasome complex
GO:0008541  proteasome regulatory particle, lid subcomplex

Molecular Function

GO:0046872  metal ion binding
GO:0008237  metallopeptidase activity
GO:0070628  proteasome binding
GO:0004221  ubiquitin thiolesterase activity