cyclin-dependent kinase inhibitor 1C (p57, Kip2)

Synonym

cyclin-dependent kinase inhibitor 1C (p57, Kip2), BWS, KIP2, Beckwith-Wiedemann syndrome, Cyclin-dependent kinase inhibitor 1C, BWCR, p57, p57KIP2, Cyclin-dependent kinase inhibitor p57, CDKN1C

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:11.90

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:199.80

artery/aorta:30

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:25.80

bone marrow:19.70

adipose:40.30

bone:-

skin:33.60

GeneChip

cerebrum:8.23

cerebellum:6.45

brain stem:8.97

corpus callosum/glia:9.73

pineal gland:-

peripheral nerve:8.65

spine:9.68

retina:-

eye:-

artery/aorta:7.96

vein:7.26

lymphnode:6.50

peripheral blood:-

spleen:7.43

thymus:5.74

bone marrow:5.86

adipose:8.69

bone:-

skin:7.24

CAGE

cerebrum:2.94

cerebellum:-

brain stem:4.02

corpus callosum/glia:4.33

pineal gland:0.97

peripheral nerve:-

spine:4.27

retina:-

eye:-

artery/aorta:3.24

vein:3.29

lymphnode:1.90

peripheral blood:-

spleen:2.31

thymus:1.12

bone marrow:-

adipose:4.09

bone:-

skin:-

RNA-seq

cerebrum:4.30

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.46

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:5.24

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:446.50

placenta:582.90

prostate:45.10

ovary:-

testis:26

heart:587.50

muscle:100.50

esophagus:-

stomach:-

intestine:32.40

colon:17

liver/hepato:21.10

lung:112.40

bladder:-

kidney:135.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:702.40

breast:9.30

salivary:-

GeneChip

uterus:8.23

placenta:10.68

prostate:7.68

ovary:8.24

testis:5.76

heart:8.27

muscle:8.12

esophagus:7.28

stomach:7.42

intestine:7.56

colon:7.07

liver/hepato:6.07

lung:8.10

bladder:-

kidney:8.75

pituitary:7.51

thyroid/parathyroid:7.35

adrenal gland:9.38

pancreas:7.39

breast:8.27

salivary:7.13

CAGE

uterus:3.69

placenta:5.93

prostate:3.57

ovary:4.04

testis:2.96

heart:3.40

muscle:3.34

esophagus:3.76

stomach:-

intestine:2.61

colon:2.81

liver/hepato:1.07

lung:3.22

bladder:3.87

kidney:4.03

pituitary:2.32

thyroid/parathyroid:2.79

adrenal gland:-

pancreas:2.26

breast:4.23

salivary:2.35

RNA-seq

uterus:-

placenta:-

prostate:5.31

ovary:4.55

testis:3.25

heart:3.79

muscle:4.24

esophagus:-

stomach:-

intestine:-

colon:4.33

liver/hepato:1.85

lung:3.87

bladder:-

kidney:6.04

pituitary:-

thyroid/parathyroid:2.52

adrenal gland:2.28

pancreas:-

breast:4.73

salivary:-

IDs

Refseq ID	NM_001122630
Gene ID	1028
Unigene ID	Hs.106070
Probe set ID	213348_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000129757
GTEx ID	ENSG00000129757

Orthologous Gene

Mouse[2]	NM_001161624, NM_009876
Rat[1]	NM_001033757, NM_009876

Chromosomal Region

11p15.4 [2,904,443 - 2,907,111]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0007050	cell cycle arrest
GO:0000080	G1 phase of mitotic cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0033673	negative regulation of kinase activity
GO:0042326	negative regulation of phosphorylation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0042551	neuron maturation
GO:0001890	placenta development
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0000079	regulation of cyclin-dependent protein kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005730	nucleolus
GO:0005634	nucleus

Molecular Function

GO:0004861	cyclin-dependent protein kinase inhibitor activity
GO:0005515	protein binding

cyclin-dependent kinase inhibitor 1C (p57, Kip2)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function