cyclin-dependent kinase inhibitor 3

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Synonym

CDKN3, CDI1, MGC70625, Cyclin-dependent kinase-interacting protein 2, CDK2-associated dual-specificity phosphatase, FLJ25787, Cyclin-dependent kinase inhibitor 3, CIP2, Kinase-associated phosphatase, KAP1, Cyclin-dependent kinase interactor 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:133.30 lymphnode:101.10 peripheral blood:36.40 spleen:- thymus:- bone marrow:39.40 adipose:- bone:- skin:9.60
GeneChip cerebrum:4.90 cerebellum:4.98 brain stem:5.22 corpus callosum/glia:4.40 pineal gland:- peripheral nerve:5.49 spine:4.63 retina:- eye:- artery/aorta:4.65 vein:4.88 lymphnode:5.38 peripheral blood:- spleen:4.31 thymus:7.06 bone marrow:7.29 adipose:4.96 bone:- skin:5.22
CAGE cerebrum:1.34 cerebellum:- brain stem:1.36 corpus callosum/glia:0.55 pineal gland:1.08 peripheral nerve:- spine:1.05 retina:- eye:- artery/aorta:0.69 vein:1.73 lymphnode:2.11 peripheral blood:- spleen:1.80 thymus:3.46 bone marrow:- adipose:1.84 bone:- skin:-
RNA-seq cerebrum:1.91 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.08 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.71 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:7.30 prostate:- ovary:111.80 testis:56.20 heart:38.30 muscle:- esophagus:- stomach:21.20 intestine:- colon:25.40     liver/hepato:10.60        lung:14.70    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:53.30 breast:18.60 salivary:-
GeneChip uterus:4.93 placenta:4.97 prostate:4.23 ovary:4.69 testis:10.53 heart:5.31 muscle:5.14 esophagus:5.70 stomach:5.32 intestine:5.61 colon:6.21 liver/hepato:4.44 lung:4.41 bladder:- kidney:4.46 pituitary:4.56 thyroid/parathyroid:4.25 adrenal gland:4.65 pancreas:5.32 breast:4.69 salivary:4.62
CAGE uterus:1.10 placenta:1.76 prostate:1.03 ovary:1.16 testis:5.13 heart:1.63 muscle:1.37 esophagus:2.10 stomach:- intestine:2.06 colon:2.24     liver/hepato:0.90    lung:0.93 bladder:1.73 kidney:1.01 pituitary:0.99 thyroid/parathyroid:1.23 adrenal gland:- pancreas:0 breast:1.53 salivary:1.00
RNA-seq uterus:- placenta:- prostate:0.45 ovary:0.67 testis:7.25 heart:1.07 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.95     liver/hepato:0.00        lung:1.04    bladder:- kidney:0.80 pituitary:- thyroid/parathyroid:1.04 adrenal gland:1.93 pancreas:- breast:0.95 salivary:-

Gene Information

IDs

Refseq ID NM_005192
Gene ID 1033
Unigene ID Hs.84113
Probe set ID 209714_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100526
GTEx ID ENSG00000100526

Orthologous Gene

Mouse[1]  NM_028222
Rat[1]  NM_028222

Chromosomal Region

14q22.2  [54,863,567  -  54,886,936]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7569954
7698009
8127873
8242750
8242751
9840943
9989807
10669749
10987270
11463386
11684017
11781350
12477932
12745075
15147518
15530371
15671017
16945326
17056014
19728335
20677014
21107309
21396835
21535270
21577200
21890473
22390936
23000965
23259602
23292002
23405241
23555623
23775190
23934736

Gene Ontology  (GO ID)

Biological Process

GO:0007050  cell cycle arrest
GO:0000082  G1/S transition of mitotic cell cycle
GO:0008285  negative regulation of cell proliferation
GO:0000079  regulation of cyclin-dependent protein kinase activity

Cellular Component

GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0005515  protein binding
GO:0004722  protein serine/threonine phosphatase activity
GO:0004725  protein tyrosine phosphatase activity
GO:0008138  protein tyrosine/serine/threonine phosphatase activity