nucleotide-binding oligomerization domain containing 1

Synonym

Nod1, caspase recruitment domain family, member 4, Caspase recruitment domain-containing protein 4, CARD4, Protein Nod1, NOD1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:7.10

cerebellum:25.20

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:61.30

spine:224.60

retina:-

eye:5.90

artery/aorta:-

vein:66.60

lymphnode:10.10

peripheral blood:36.40

spleen:56.70

thymus:12.90

bone marrow:19.70

adipose:40.30

bone:25.60

skin:33.60

GeneChip

cerebrum:6.79

cerebellum:6.77

brain stem:6.82

corpus callosum/glia:6.79

pineal gland:-

peripheral nerve:7.13

spine:6.68

retina:-

eye:-

artery/aorta:7.34

vein:7.30

lymphnode:7.34

peripheral blood:-

spleen:7.64

thymus:6.97

bone marrow:7.47

adipose:7.41

bone:-

skin:7.45

CAGE

cerebrum:1.19

cerebellum:-

brain stem:1.49

corpus callosum/glia:1.71

pineal gland:1.38

peripheral nerve:-

spine:1.89

retina:-

eye:-

artery/aorta:2.61

vein:2.40

lymphnode:2.30

peripheral blood:-

spleen:2.62

thymus:1.73

bone marrow:-

adipose:2.80

bone:-

skin:-

RNA-seq

cerebrum:0.85

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.49

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.99

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:63.80

placenta:14.60

prostate:-

ovary:-

testis:13

heart:-

muscle:20.10

esophagus:-

stomach:-

intestine:-

colon:93.30

liver/hepato:31.70

lung:39.10

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:7.04

placenta:7.21

prostate:6.65

ovary:7.28

testis:6.59

heart:7.49

muscle:6.98

esophagus:7.15

stomach:7.24

intestine:7.11

colon:7.33

liver/hepato:6.94

lung:7.50

bladder:-

kidney:6.89

pituitary:6.87

thyroid/parathyroid:6.90

adrenal gland:7.01

pancreas:6.42

breast:7.27

salivary:7.34

CAGE

uterus:2.34

placenta:2.10

prostate:1.96

ovary:2.71

testis:1.49

heart:2.67

muscle:1.83

esophagus:2.05

stomach:-

intestine:1.66

colon:2.33

liver/hepato:1.29

lung:2.94

bladder:2.22

kidney:1.53

pituitary:1.68

thyroid/parathyroid:3.31

adrenal gland:-

pancreas:1.59

breast:3.06

salivary:2.31

RNA-seq

uterus:-

placenta:-

prostate:2.12

ovary:2.71

testis:1.48

heart:1.13

muscle:0.34

esophagus:-

stomach:-

intestine:-

colon:2.16

liver/hepato:0.56

lung:2.91

bladder:-

kidney:1.47

pituitary:-

thyroid/parathyroid:2.66

adrenal gland:2.50

pancreas:-

breast:1.92

salivary:-

IDs

Refseq ID	NM_006092
Gene ID	10392
Unigene ID	Hs.405153
Probe set ID	221073_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000106100
GTEx ID	ENSG00000106100

Orthologous Gene

Mouse[1]	NM_001171007, NM_172729
Rat[1]	NM_001109236, NM_172729

Chromosomal Region

7p14.3 [30,464,143 - 30,518,400]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001315	Caspase Recruitment
IPR011029	DEATH-like

Gene Ontology (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0000187	activation of MAPK activity
GO:0006915	apoptosis
GO:0006952	defense response
GO:0042742	defense response to bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0016045	detection of bacterium
GO:0009595	detection of biotic stimulus
GO:0006917	induction of apoptosis
GO:0006954	inflammatory response
GO:0045087	innate immune response
GO:0042228	interleukin-8 biosynthetic process
GO:0007254	JNK cascade
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032755	positive regulation of interleukin-6 production
GO:0046330	positive regulation of JNK cascade
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0032760	positive regulation of tumor necrosis factor production
GO:0051259	protein oligomerization
GO:0007165	signal transduction
GO:0051403	stress-activated MAPK cascade
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway

Cellular Component

GO:0016324	apical plasma membrane
GO:0016323	basolateral plasma membrane
GO:0005737	cytoplasm
GO:0005829	cytosol

Molecular Function

GO:0005524	ATP binding
GO:0050700	CARD domain binding
GO:0008656	caspase activator activity
GO:0042802	identical protein binding
GO:0042834	peptidoglycan binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

nucleotide-binding oligomerization domain containing 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function